====== Wortmannin 0.5μM R00 exp37 ====== ==== Mechanism of Action ==== Inhibits PI3K and PI3K-related enzymes, non-specific covalent inhibitor * **Class / Subclass 1:** Signal Transduction / Kinase Inhibitor * **Class / Subclass 2:** Proteostasis / Autophagy Inhibitor ==== Technical Notes ==== * **PubChem Name:** %%Wortmannin%% * **Synonyms:** SL-2052; KY-12420 * **CAS #:** 19545-26-7 * **PubChem CID:** [[https://pubchem.ncbi.nlm.nih.gov/compound/312145|312145]] * **IUPAC:** %%[(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate%% * **INCHI Name:** InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 * **INCHI Key:** QDLHCMPXEPAAMD-QAIWCSMKSA-N * **Molecular Weight:** 428.4 * **Canonical SMILES:** CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C * **Isomeric SMILES:** CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C * **Molecular Formula:** DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG {{:chemogenomics:structures:chem-0020.svg?nolink}} * **Supplier Name:** LC Laboratories * **Catalog #:** W-2990 * **Lot #:** SS-107 * **HRMS (ESI-TOF) m/z:** (M+Na)+ Calcd for C23H24O8 451.13634; found 451.1358 * **Platform ID:** Wortmannin * **Min:** -10.7381; **Max:** 63.3011 {{:chemogenomics:dose_response:dr_280.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |N/A | | IC20 |1.6783 | | IC30 |3.4255 | | IC40 |6.1479 | | IC50 |10.5153 | | IC60 |N/A | | IC70 |N/A | | IC80 |N/A | | IC90 |N/A | \\ ==== Screen Summary ==== * **Round**: 00 * **Dose**: 500nM * **Days of incubation**: 8 * **Doublings**: 5.7 * **Numbers of reads**: 9470449 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |6/3|[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Wortmannin_0.5uM_Round-0_exp37.txt|Scores]]|||||| {{:chemogenomics:cranks_plots:exp37.png?nolink}} ^Gene^CRANKS Score^FDR^ |[[:human_genes:K:KIAA1432|KIAA1432]]|-3.24|<0.01| |[[:human_genes:A:ASB3|ASB3]]|-3.02|<0.01| |[[:human_genes:P:PRKAG1|PRKAG1]]|-2.95|<0.01| |[[:human_genes:D:DCAF15|DCAF15]]|-2.92|0.02| |[[:human_genes:T:TCF4|TCF4]]|-2.86|0.01| |[[:human_genes:A:ARL1|ARL1]]|-2.75|0.02| |[[:human_genes:P:PARL|PARL]]|-2.41|0.15| |[[:human_genes:P:PGGT1B|PGGT1B]]|-2.40|0.10| |[[:human_genes:G:GPR107|GPR107]]|-2.33|0.12| |[[:human_genes:M:MAP6|MAP6]]|-2.32|0.17| |[[:human_genes:Q:QRICH1|QRICH1]]|-2.32|0.17| |[[:human_genes:D:DNTTIP1|DNTTIP1]]|-2.32|0.12| |[[:human_genes:O:ORC3|ORC3]]|-2.27|0.29| |[[:human_genes:H:HSP90B1|HSP90B1]]|-2.25|0.29| |[[:human_genes:M:MAPKAP1|MAPKAP1]]|-2.22|0.21| |[[:human_genes:M:MLC1|MLC1]]|-2.22|0.17| |[[:human_genes:C:CCDC85C|CCDC85C]]|-2.18|0.17| |[[:human_genes:M:METTL16|METTL16]]|-2.18|0.40| |[[:human_genes:U:USP17L17|USP17L17]]|-2.17|0.55| |[[:human_genes:S:SLC5A3|SLC5A3]]|-2.16|0.18| |[[:human_genes:S:SEPHS1|SEPHS1]]|-2.15|0.18| |[[:human_genes:S:SHOC2|SHOC2]]|-2.15|0.28| |[[:human_genes:D:DLX6|DLX6]]|-2.12|0.19| |[[:human_genes:P:PIKFYVE|PIKFYVE]]|-2.12|0.19| |[[:human_genes:A:ANAPC11|ANAPC11]]|-2.11|0.34| |[[:human_genes:P:POLR1E|POLR1E]]|-2.09|0.29| |[[:human_genes:S:SPEN|SPEN]]|-2.08|0.29| |[[:human_genes:E:EPG5|EPG5]]|-2.06|0.25| |[[:human_genes:C:CTC1|CTC1]]|-2.04|0.30| |[[:human_genes:F:FAM60A|FAM60A]]|-2.02|0.28| |[[:human_genes:V:VAX2|VAX2]]|2.14|0.15| |[[:human_genes:S:SECISBP2L|SECISBP2L]]|2.15|0.21| |[[:human_genes:F:FAM117A|FAM117A]]|2.17|0.15| |[[:human_genes:R:RASSF9|RASSF9]]|2.18|0.15| |[[:human_genes:R:RNF32|RNF32]]|2.22|0.15| |[[:human_genes:B:BRE|BRE]]|2.23|0.15| |[[:human_genes:Z:ZNF607|ZNF607]]|2.27|0.15| |[[:human_genes:H:HIST1H1C|HIST1H1C]]|2.28|0.12| |[[:human_genes:C:CDCA3|CDCA3]]|2.30|0.15| |[[:human_genes:Z:ZNF641|ZNF641]]|2.30|0.21| |[[:human_genes:A:ATP2B1|ATP2B1]]|2.32|0.15| |[[:human_genes:S:SUPT6H|SUPT6H]]|2.35|0.40| |[[:human_genes:N:NCBP1|NCBP1]]|2.36|0.26| |[[:human_genes:Z:ZNF799|ZNF799]]|2.36|0.09| |[[:human_genes:T:TXNIP|TXNIP]]|2.38|0.09| |[[:human_genes:C:C5orf28|C5orf28]]|2.39|0.09| |[[:human_genes:P:PNPLA8|PNPLA8]]|2.46|0.15| |[[:human_genes:C:CTSV|CTSV]]|2.51|0.09| |[[:human_genes:M:MMP16|MMP16]]|2.53|0.05| |[[:human_genes:N:NFE2L2|NFE2L2]]|2.56|0.05| |[[:human_genes:U:USP17L19|USP17L19]]|2.59|0.15| |[[:human_genes:E:EIF3B|EIF3B]]|2.59|0.12| |[[:human_genes:K:KREMEN1|KREMEN1]]|2.60|0.05| |[[:human_genes:D:DTX3L|DTX3L]]|2.67|0.05| |[[:human_genes:N:NHP2L1|NHP2L1]]|2.75|0.17| |[[:human_genes:C:COPE|COPE]]|2.79|0.15| |[[:human_genes:M:MEMO1|MEMO1]]|2.84|0.02| |[[:human_genes:R:RBM39|RBM39]]|2.85|0.36| |[[:human_genes:T:TSC2|TSC2]]|2.95|0.02| |[[:human_genes:K:KIF11|KIF11]]|3.00|0.31| ^Screen^Correlation^Plot^ |[[:results:exp38|Wortmannin 5μM R00 exp38]]|0.091|| |[[:results:exp32|Rifampicin 10μM R00 exp32]]|0.074|| |[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|0.073|| |[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|0.062|| |[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|0.056|| |[[:results:exp16|DABN 2μM R00 exp16]]|0.055|| |[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.054|| |[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.054|| |[[:results:exp29|Rapamycin 1μM R00 exp29]]|0.051|| {{:chemogenomics:comparison_plots:exp37_vs_exp38.png?nolink |}} {{:chemogenomics:comparison_plots:exp32_vs_exp37.png?nolink |}} {{:chemogenomics:comparison_plots:exp27_vs_exp37.png?nolink |}} {{:chemogenomics:comparison_plots:exp23_vs_exp37.png?nolink |}} {{:chemogenomics:comparison_plots:exp37_vs_exp5.png?nolink |}} {{:chemogenomics:comparison_plots:exp16_vs_exp37.png?nolink |}} {{:chemogenomics:comparison_plots:exp37_vs_exp467.png?nolink |}} {{:chemogenomics:comparison_plots:exp37_vs_exp77.png?nolink |}} {{:chemogenomics:comparison_plots:exp29_vs_exp37.png?nolink |}} No GO term hits below threshold. (FDR <0.05) No GO term hits below threshold. (FDR <0.05)