====== Vemurafenib 6.6μM R08 exp434 ======
==== Mechanism of Action ====
Inhibits BRAF-V300E, paradoxical RAF activation by stabilization of CRAF/BRAF heterodimer
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Kinase Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Vemurafenib%%
    * **<color #00a2e8>Synonyms:</color>** PLX4032; RG7204; RO5185426
    * **<color #00a2e8>CAS #:</color>** 918504-65-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/42611257|42611257]]
    * **<color #00a2e8>IUPAC:</color>** %%N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
    * **<color #00a2e8>INCHI Key:</color>** GPXBXXGIAQBQNI-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 489.9
    * **<color #00a2e8>Canonical SMILES:</color>** CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C23H18ClF2N3O3S
{{:chemogenomics:structures:chem-0065.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-12057
    * **<color #00a2e8>Lot #:</color>** 23749
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C23H18ClF2N3O3S 490.07982; found 490.0813
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Vemurafenib
    * **<color #00a2e8>Min:</color>** -0.5775; **<color #00a2e8>Max:</color>** 99.8470
{{:chemogenomics:dose_response:dr_631.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.3969    |
| IC20  |0.7983    |
| IC30  |1.2700    |
| IC40  |1.8590    |
| IC50  |2.6360    |
| IC60  |3.7390    |
| IC70  |5.4720    |
| IC80  |8.7070    |
| IC90  |17.5100    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 6.6µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.0
    * **<color #00a2e8>Numbers of reads</color>**: 15820409


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|111/105|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Vemurafenib_6.6uM_Round-8_exp434.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Vemurafenib 6.6μM R08 exp434'>
{{:chemogenomics:cranks_plots:exp434.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:G:GPR107|GPR107]]|-5.73|0.00|
|[[:human_genes:S:SLC39A9|SLC39A9]]|-5.44|0.00|
|[[:human_genes:A:APBA3|APBA3]]|-4.69|0.00|
|[[:human_genes:A:ACBD3|ACBD3]]|-4.58|0.00|
|[[:human_genes:A:ARL5B|ARL5B]]|-4.57|0.00|
|[[:human_genes:T:TBC1D23|TBC1D23]]|-4.55|0.00|
|[[:human_genes:T:TM9SF3|TM9SF3]]|-4.35|0.00|
|[[:human_genes:C:CHKA|CHKA]]|-4.33|0.00|
|[[:human_genes:A:ARL1|ARL1]]|-4.14|0.00|
|[[:human_genes:V:VKORC1L1|VKORC1L1]]|-4.13|0.00|
|[[:human_genes:L:LDLR|LDLR]]|-3.96|0.00|
|[[:human_genes:U:UGCG|UGCG]]|-3.65|0.00|
|[[:human_genes:S:SPTLC1|SPTLC1]]|-3.62|0.00|
|[[:human_genes:R:RALGAPB|RALGAPB]]|-3.54|0.00|
|[[:human_genes:M:MON2|MON2]]|-3.53|0.00|
|[[:human_genes:N:NRAS|NRAS]]|-3.41|0.00|
|[[:human_genes:C:C12orf23|C12orf23]]|-3.41|0.00|
|[[:human_genes:T:TBC1D22B|TBC1D22B]]|-3.37|0.00|
|[[:human_genes:M:METAP1|METAP1]]|-3.36|0.00|
|[[:human_genes:B:BRD1|BRD1]]|-3.33|0.00|
|[[:human_genes:K:KDSR|KDSR]]|-3.33|0.00|
|[[:human_genes:M:MMD|MMD]]|-3.31|0.00|
|[[:human_genes:M:MS4A13|MS4A13]]|-3.28|0.07|
|[[:human_genes:C:COPB2|COPB2]]|-3.25|<0.01|
|[[:human_genes:H:HMGB2|HMGB2]]|-3.20|0.00|
|[[:human_genes:I:IGLL1|IGLL1]]|-3.17|0.00|
|[[:human_genes:Y:YIPF5|YIPF5]]|-3.17|0.00|
|[[:human_genes:I:IER3IP1|IER3IP1]]|-3.16|0.00|
|[[:human_genes:S:SCAP|SCAP]]|-3.09|0.00|
|[[:human_genes:A:ARL5A|ARL5A]]|-3.08|0.00|
|[[:human_genes:B:BRAP|BRAP]]|2.94|<0.01|
|[[:human_genes:A:ATP8B2|ATP8B2]]|2.94|<0.01|
|[[:human_genes:H:HEATR5B|HEATR5B]]|3.05|0.00|
|[[:human_genes:T:TNPO1|TNPO1]]|3.05|<0.01|
|[[:human_genes:D:DAZAP1|DAZAP1]]|3.07|0.00|
|[[:human_genes:I:INSIG1|INSIG1]]|3.08|<0.01|
|[[:human_genes:W:WIBG|WIBG]]|3.13|<0.01|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|3.14|0.00|
|[[:human_genes:T:TSC2|TSC2]]|3.16|0.00|
|[[:human_genes:R:RQCD1|RQCD1]]|3.18|0.00|
|[[:human_genes:S:SEC24C|SEC24C]]|3.25|0.00|
|[[:human_genes:T:TVP23C-CDRT4|TVP23C-CDRT4]]|3.32|<0.01|
|[[:human_genes:M:MBOAT7|MBOAT7]]|3.34|0.00|
|[[:human_genes:N:NUDT5|NUDT5]]|3.36|0.00|
|[[:human_genes:Y:YIPF6|YIPF6]]|3.48|0.00|
|[[:human_genes:A:ABCG1|ABCG1]]|3.51|0.00|
|[[:human_genes:R:RBM38|RBM38]]|3.67|0.00|
|[[:human_genes:C:CHP1|CHP1]]|3.80|0.00|
|[[:human_genes:F:FKBPL|FKBPL]]|3.80|0.00|
|[[:human_genes:C:CARM1|CARM1]]|4.20|0.00|
|[[:human_genes:S:SH3BP5L|SH3BP5L]]|4.23|0.00|
|[[:human_genes:M:MBD2|MBD2]]|4.39|0.00|
|[[:human_genes:T:TMEM30A|TMEM30A]]|4.45|0.00|
|[[:human_genes:E:ELF1|ELF1]]|4.46|0.00|
|[[:human_genes:K:KIAA2013|KIAA2013]]|4.53|0.00|
|[[:human_genes:T:TRAPPC9|TRAPPC9]]|4.95|0.00|
|[[:human_genes:T:TM9SF2|TM9SF2]]|5.18|0.00|
|[[:human_genes:T:TRAPPC10|TRAPPC10]]|5.57|0.00|
|[[:human_genes:R:RAB11A|RAB11A]]|6.49|0.00|
|[[:human_genes:P:PITPNB|PITPNB]]|8.00|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|0.296|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|0.155|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.115|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.098|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.089|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|0.089|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|0.077|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.077|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.068|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.056|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.056|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|0.054|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.052|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|0.051|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|0.051|<button type="primary" size="small" modal="15">View</button>|
</modal>


<modal id="1" size="lg" title="Vemurafenib 6.6μM R02 exp89  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp89.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Clomiphene 4.4μM R02 exp68  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp68.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Bafilomycin-A1 0.009μM R08 exp454  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp454.png?nolink |}}
</modal>

<modal id="4" size="lg" title="BH1 1μM R04 exp169  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp169_vs_exp434.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp164_vs_exp434.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Q15 2.7μM R02 exp79  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp79.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Monensin 0.3μM R08 exp507  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp507.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Tubacin 1.6μM R07 exp416  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp416_vs_exp434.png?nolink |}}
</modal>

<modal id="9" size="lg" title="UM0125461 0.74μM R02 exp84  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp84.png?nolink |}}
</modal>

<modal id="10" size="lg" title="BS-181 20μM R08 exp461  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp461.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Thioridazine 5μM R08 exp530  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp530.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Oligomycin-A 2μM R00 exp25  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp25_vs_exp434.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp329_vs_exp434.png?nolink |}}
</modal>

<modal id="14" size="lg" title="CFI-400945 25μM R08 exp469  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp469.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Chloroquine 32μM R08 exp470  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp470.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|phospholipid transporter activity|36.22|PITPNB,TMEM30A,ABCG1,ATP8B2|
</modal>