====== Dynasore 7μM R08 exp436 ======
==== Mechanism of Action ====
Putative dynamin GTPase inhibitor, blocks endocytosis
  * **<color #00a2e8>Class / Subclass 1:</color>** Organelle Function / Vesicule Trafficking Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Dynasore%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 304448-55-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/135533054|135533054]]
    * **<color #00a2e8>IUPAC:</color>** %%N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
    * **<color #00a2e8>INCHI Key:</color>** SYNDQCRDGGCQRZ-VXLYETTFSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 322.3
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
    * **<color #00a2e8>Molecular Formula:</color>** C18H14N2O4
{{:chemogenomics:structures:chem-0113.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** ChemCruz
    * **<color #00a2e8>Catalog #:</color>** SC-202592
    * **<color #00a2e8>Lot #:</color>** B2216
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C18H14N2O4 323.10263; found 323.10352
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Dynasore
    * **<color #00a2e8>Min:</color>** -11.5179; **<color #00a2e8>Max:</color>** 91.1660
{{:chemogenomics:dose_response:dr_530.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |3.2450    |
| IC20  |5.0690    |
| IC30  |6.8190    |
| IC40  |8.6950    |
| IC50  |10.8700    |
| IC60  |13.5800    |
| IC70  |17.3200    |
| IC80  |23.3000    |
| IC90  |36.3900    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 7µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.5
    * **<color #00a2e8>Numbers of reads</color>**: 16667359


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|19/3|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Dynasore_7uM_Round-8_exp436.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Dynasore 7μM R08 exp436'>
{{:chemogenomics:cranks_plots:exp436.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ACSL4|ACSL4]]|-4.13|<0.01|
|[[:human_genes:S:SEC31A|SEC31A]]|-3.98|<0.01|
|[[:human_genes:G:GCLM|GCLM]]|-3.55|<0.01|
|[[:human_genes:P:PEX7|PEX7]]|-3.53|<0.01|
|[[:human_genes:C:CHKA|CHKA]]|-3.49|<0.01|
|[[:human_genes:D:DNAJC3|DNAJC3]]|-3.26|<0.01|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.99|0.02|
|[[:human_genes:V:VKORC1L1|VKORC1L1]]|-2.93|<0.01|
|[[:human_genes:D:DEPDC5|DEPDC5]]|-2.91|0.01|
|[[:human_genes:A:AAAS|AAAS]]|-2.69|0.03|
|[[:human_genes:H:HSPA4|HSPA4]]|-2.62|0.03|
|[[:human_genes:C:CNOT2|CNOT2]]|-2.61|0.02|
|[[:human_genes:C:CNOT8|CNOT8]]|-2.51|0.03|
|[[:human_genes:A:ATL2|ATL2]]|-2.48|0.03|
|[[:human_genes:H:HDAC3|HDAC3]]|-2.47|0.03|
|[[:human_genes:D:DNAJB11|DNAJB11]]|-2.43|0.11|
|[[:human_genes:X:XPR1|XPR1]]|-2.40|0.04|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.40|0.04|
|[[:human_genes:S:SHOC2|SHOC2]]|-2.39|0.07|
|[[:human_genes:C:CHMP7|CHMP7]]|-2.38|0.04|
|[[:human_genes:X:XPO5|XPO5]]|-2.38|0.12|
|[[:human_genes:B:BCL2|BCL2]]|-2.35|0.05|
|[[:human_genes:U:UPF3B|UPF3B]]|-2.30|0.06|
|[[:human_genes:N:NUP35|NUP35]]|-2.30|0.06|
|[[:human_genes:A:ADIPOR2|ADIPOR2]]|-2.28|0.06|
|[[:human_genes:M:MSL2|MSL2]]|-2.27|0.06|
|[[:human_genes:D:DDA1|DDA1]]|-2.24|0.07|
|[[:human_genes:V:VPS25|VPS25]]|-2.23|0.42|
|[[:human_genes:K:KPNA2|KPNA2]]|-2.22|0.08|
|[[:human_genes:S:SNF8|SNF8]]|-2.21|0.12|
|[[:human_genes:C:CERS6|CERS6]]|2.05|0.26|
|[[:human_genes:M:MS4A13|MS4A13]]|2.05|0.69|
|[[:human_genes:Z:ZNF844|ZNF844]]|2.05|0.26|
|[[:human_genes:F:FADS1|FADS1]]|2.06|0.26|
|[[:human_genes:S:SLC31A1|SLC31A1]]|2.07|0.34|
|[[:human_genes:T:TMEM14E|TMEM14E]]|2.07|0.26|
|[[:human_genes:F:FECH|FECH]]|2.07|0.26|
|[[:human_genes:I:IGSF10|IGSF10]]|2.08|0.26|
|[[:human_genes:A:ATP8B2|ATP8B2]]|2.10|0.41|
|[[:human_genes:S:SLC37A4|SLC37A4]]|2.13|0.44|
|[[:human_genes:O:OR1N1|OR1N1]]|2.14|0.29|
|[[:human_genes:C:CCNL1|CCNL1]]|2.15|0.22|
|[[:human_genes:R:RPL27A|RPL27A]]|2.17|0.50|
|[[:human_genes:C:CDC45|CDC45]]|2.18|0.50|
|[[:human_genes:H:HMOX2|HMOX2]]|2.18|0.20|
|[[:human_genes:M:MRPL47|MRPL47]]|2.22|0.19|
|[[:human_genes:A:ALAD|ALAD]]|2.26|0.23|
|[[:human_genes:B:BAK1|BAK1]]|2.29|0.14|
|[[:human_genes:S:SCN11A|SCN11A]]|2.33|0.20|
|[[:human_genes:C:CDK2|CDK2]]|2.33|0.13|
|[[:human_genes:T:TSPY8|TSPY8]]|2.36|0.51|
|[[:human_genes:L:LDB3|LDB3]]|2.42|0.14|
|[[:human_genes:A:ALAS1|ALAS1]]|2.44|0.29|
|[[:human_genes:A:ALG1L|ALG1L]]|2.51|0.05|
|[[:human_genes:S:SLFN11|SLFN11]]|2.59|0.05|
|[[:human_genes:E:EIF4A1|EIF4A1]]|2.71|0.05|
|[[:human_genes:M:MYLIP|MYLIP]]|2.72|0.05|
|[[:human_genes:H:HMBS|HMBS]]|3.10|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|3.29|<0.01|
|[[:human_genes:F:FADS2|FADS2]]|3.35|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.106|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.083|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.061|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|0.06|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|0.145|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|0.079|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|0.065|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.059|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|0.054|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|0.054|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.052|<button type="primary" size="small" modal="11">View</button>|
</modal>


<modal id="1" size="lg" title="Dynasore 7μM R08 exp436  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp436_vs_exp517.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Dynasore 7μM R08 exp436  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp416_vs_exp436.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Dynasore 7μM R08 exp436  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp436_vs_exp84.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Dynasore 7μM R08 exp436  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp436_vs_exp78.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Dynasore 10μM R04 exp180  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp180_vs_exp436.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp356_vs_exp436.png?nolink |}}
</modal>

<modal id="7" size="lg" title="5-Azacytidine 2μM R07 exp330  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp330_vs_exp436.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp227_vs_exp436.png?nolink |}}
</modal>

<modal id="9" size="lg" title="3-Bromopyruvate 7μM R04 exp175  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp175_vs_exp436.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Alpha-Amanitin 0.5μM R00 exp5  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp436_vs_exp5.png?nolink |}}
</modal>

<modal id="11" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp436_vs_exp474.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|acyl-CoA desaturase activity|368.20|FADS2,FADS1|
|protoporphyrinogen IX metabolic process|220.92|HMBS,ALAS1,ALAD,FECH|
|protoporphyrinogen IX biosynthetic process|207.11|HMBS,ALAS1,ALAD|
|heme biosynthetic process|88.37|HMBS,ALAS1,ALAD,FECH|
|tetrapyrrole biosynthetic process|78.90|HMBS,ALAS1,ALAD,FECH|
|porphyrin-containing compound biosynthetic process|78.90|HMBS,ALAS1,ALAD,FECH|
|heme metabolic process|70.81|HMBS,ALAS1,ALAD,HMOX2,FECH|
|porphyrin-containing compound metabolic process|60.03|HMBS,ALAS1,ALAD,HMOX2,FECH|
|pigment biosynthetic process|53.88|HMBS,ALAS1,ALAD,FECH|
|tetrapyrrole metabolic process|51.14|HMBS,ALAS1,ALAD,HMOX2,FECH|
|pigment metabolic process|43.15|HMBS,ALAS1,ALAD,HMOX2,FECH|
</modal>