====== Artemisinin 50μM R08 exp450 ======
==== Mechanism of Action ====
Sesquiterpene endoperoxide activated by heme, kills malaria parasite through oxidative damage
  * **<color #00a2e8>Class / Subclass 1:</color>** Infectious Disease / Antimalarial




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Artemisinin%%
    * **<color #00a2e8>Synonyms:</color>** Qinghaosu; NSC 369397
    * **<color #00a2e8>CAS #:</color>** 63968-64-9
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/68827|68827]]
    * **<color #00a2e8>IUPAC:</color>** %%(1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** BLUAFEHZUWYNDE-NNWCWBAJSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 282.33
    * **<color #00a2e8>Canonical SMILES:</color>** CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)C
    * **<color #00a2e8>Molecular Formula:</color>** C15H22O5
{{:chemogenomics:structures:chem-0261.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Combi-Blocks
    * **<color #00a2e8>Catalog #:</color>** QA-7358
    * **<color #00a2e8>Lot #:</color>** B22262
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C15H22O5 283.154; found 283.15465
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Artemisinin
    * **<color #00a2e8>Min:</color>** -15.4586; **<color #00a2e8>Max:</color>** 33.8695
{{:chemogenomics:dose_response:dr_500.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |7.4780    |
| IC20  |34.7400    |
| IC30  |96.4000    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 50µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.9
    * **<color #00a2e8>Numbers of reads</color>**: 31050357


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|23/126|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Artemisinin_50uM_Round-8_exp450.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Artemisinin 50μM R08 exp450'>
{{:chemogenomics:cranks_plots:exp450.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PSMB8|PSMB8]]|-3.90|<0.01|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-3.58|<0.01|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-3.36|<0.01|
|[[:human_genes:N:NGLY1|NGLY1]]|-3.33|<0.01|
|[[:human_genes:G:GCLM|GCLM]]|-3.15|<0.01|
|[[:human_genes:N:NPRL2|NPRL2]]|-3.12|0.01|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.98|0.01|
|[[:human_genes:A:ABCB10|ABCB10]]|-2.94|<0.01|
|[[:human_genes:P:PSMD2|PSMD2]]|-2.88|0.01|
|[[:human_genes:S:STARD7|STARD7]]|-2.86|0.01|
|[[:human_genes:G:GPX4|GPX4]]|-2.85|<0.01|
|[[:human_genes:C:CYB561A3|CYB561A3]]|-2.79|0.03|
|[[:human_genes:T:THAP11|THAP11]]|-2.69|0.01|
|[[:human_genes:C:C6orf136|C6orf136]]|-2.65|0.03|
|[[:human_genes:N:NFATC3|NFATC3]]|-2.62|0.03|
|[[:human_genes:H:HEXIM1|HEXIM1]]|-2.52|0.03|
|[[:human_genes:P:PSMD1|PSMD1]]|-2.49|0.08|
|[[:human_genes:N:NFE2L1|NFE2L1]]|-2.48|0.04|
|[[:human_genes:I:ITFG2|ITFG2]]|-2.45|0.03|
|[[:human_genes:U:UPF3B|UPF3B]]|-2.43|0.03|
|[[:human_genes:D:DEPDC5|DEPDC5]]|-2.42|0.06|
|[[:human_genes:P:PSMA3|PSMA3]]|-2.41|0.10|
|[[:human_genes:U:UBE2N|UBE2N]]|-2.41|0.04|
|[[:human_genes:S:SLC25A39|SLC25A39]]|-2.38|0.04|
|[[:human_genes:D:DDX3X|DDX3X]]|-2.37|0.04|
|[[:human_genes:O:OSGIN2|OSGIN2]]|-2.34|0.08|
|[[:human_genes:T:THBS1|THBS1]]|-2.34|0.04|
|[[:human_genes:P:PSMA2|PSMA2]]|-2.33|0.17|
|[[:human_genes:C:CDC73|CDC73]]|-2.32|0.12|
|[[:human_genes:P:PSMA1|PSMA1]]|-2.29|0.19|
|[[:human_genes:U:URM1|URM1]]|3.18|0.00|
|[[:human_genes:N:NDUFS2|NDUFS2]]|3.21|0.00|
|[[:human_genes:G:GRSF1|GRSF1]]|3.33|0.00|
|[[:human_genes:N:NDRG3|NDRG3]]|3.35|0.00|
|[[:human_genes:A:ATIC|ATIC]]|3.36|0.00|
|[[:human_genes:E:ENY2|ENY2]]|3.45|0.00|
|[[:human_genes:T:TPK1|TPK1]]|3.47|0.00|
|[[:human_genes:R:RFK|RFK]]|3.50|0.00|
|[[:human_genes:K:KLF16|KLF16]]|3.51|0.00|
|[[:human_genes:R:RNASEH1|RNASEH1]]|3.53|0.00|
|[[:human_genes:N:NUBPL|NUBPL]]|3.54|0.00|
|[[:human_genes:N:NFU1|NFU1]]|3.68|0.00|
|[[:human_genes:B:BAK1|BAK1]]|3.78|0.00|
|[[:human_genes:N:NDUFB11|NDUFB11]]|3.81|0.00|
|[[:human_genes:A:ATP2B1|ATP2B1]]|3.86|0.00|
|[[:human_genes:I:IBA57|IBA57]]|3.96|0.00|
|[[:human_genes:N:NDUFB9|NDUFB9]]|4.03|0.00|
|[[:human_genes:Y:YTHDF2|YTHDF2]]|4.21|0.00|
|[[:human_genes:U:UROS|UROS]]|5.21|0.00|
|[[:human_genes:M:MIPEP|MIPEP]]|5.48|0.00|
|[[:human_genes:S:SUCLG1|SUCLG1]]|5.68|0.00|
|[[:human_genes:C:CPOX|CPOX]]|5.77|0.00|
|[[:human_genes:P:PDXK|PDXK]]|6.13|0.00|
|[[:human_genes:F:FECH|FECH]]|6.57|0.00|
|[[:human_genes:S:SUCLA2|SUCLA2]]|6.83|0.00|
|[[:human_genes:G:GLRX5|GLRX5]]|7.22|0.00|
|[[:human_genes:A:ALAS1|ALAS1]]|8.02|0.00|
|[[:human_genes:A:ALAD|ALAD]]|8.42|0.00|
|[[:human_genes:P:PPOX|PPOX]]|8.49|0.00|
|[[:human_genes:H:HMBS|HMBS]]|8.49|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.137|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp360|Genistein 15μM R07 exp360]]|0.107|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|0.098|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.097|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|0.097|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.094|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.091|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.091|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.089|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.085|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.084|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.083|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.079|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.078|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.078|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.076|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.076|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.074|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.072|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.07|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.07|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.069|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.066|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.066|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|0.066|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.061|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.06|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.059|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.056|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|0.055|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|0.054|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.054|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.053|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.053|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|0.053|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.053|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.051|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|0.051|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.051|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.092|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.076|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.073|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.073|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.069|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|0.061|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.052|<button type="primary" size="small" modal="46">View</button>|
</modal>


<modal id="1" size="lg" title="Artemisinin 50μM R08 exp450  vs  Atovaquone 15μM R08 exp451">
{{:chemogenomics:comparison_plots:exp450_vs_exp451.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Artemisinin 50μM R08 exp450  vs  Genistein 15μM R07 exp360">
{{:chemogenomics:comparison_plots:exp360_vs_exp450.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Artemisinin 50μM R08 exp450  vs  HMS-I2 10μM R06 exp288">
{{:chemogenomics:comparison_plots:exp288_vs_exp450.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Artemisinin 50μM R08 exp450  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp450_vs_exp84.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Artemisinin 50μM R08 exp450  vs  Oligomycin-A 2μM R00 exp25">
{{:chemogenomics:comparison_plots:exp25_vs_exp450.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Artemisinin 50μM R08 exp450  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp450_vs_exp85.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Artemisinin 50μM R08 exp450  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp450_vs_exp529.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Artemisinin 50μM R08 exp450  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp450_vs_exp515.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Artemisinin 50μM R08 exp450  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp450.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Artemisinin 50μM R08 exp450  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp450.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Artemisinin 50μM R08 exp450  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp416_vs_exp450.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Artemisinin 50μM R08 exp450  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp450_vs_exp478.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Artemisinin 50μM R08 exp450  vs  Bleomycin 5μM R08 exp459">
{{:chemogenomics:comparison_plots:exp450_vs_exp459.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Artemisinin 50μM R08 exp450  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp450_vs_exp503.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Artemisinin 50μM R08 exp450  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp450_vs_exp489.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Artemisinin 50μM R08 exp450  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp450.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Artemisinin 50μM R08 exp450  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp450_vs_exp474.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Artemisinin 50μM R08 exp450  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp450_vs_exp488.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Artemisinin 50μM R08 exp450  vs  Benzoate 20000μM R08 exp456">
{{:chemogenomics:comparison_plots:exp450_vs_exp456.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Artemisinin 50μM R08 exp450  vs  CI-1040 9.5μM R08 exp472">
{{:chemogenomics:comparison_plots:exp450_vs_exp472.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Artemisinin 50μM R08 exp450  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp450_vs_exp517.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Artemisinin 50μM R08 exp450  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp450_vs_exp468.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Artemisinin 50μM R08 exp450  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp450.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Artemisinin 50μM R08 exp450  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp450_vs_exp512.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Artemisinin 50μM R08 exp450  vs  Calcium Ionophore 0.4μM R07 exp342">
{{:chemogenomics:comparison_plots:exp342_vs_exp450.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Artemisinin 50μM R08 exp450  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp435_vs_exp450.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Artemisinin 50μM R08 exp450  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp450_vs_exp527.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Artemisinin 50μM R08 exp450  vs  LY2090314 0.003μM R08 exp500 no dilution day6">
{{:chemogenomics:comparison_plots:exp450_vs_exp500.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Artemisinin 50μM R08 exp450  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp450.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Artemisinin 50μM R08 exp450  vs  ONC212 0.15μM R08 exp513">
{{:chemogenomics:comparison_plots:exp450_vs_exp513.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Artemisinin 50μM R08 exp450  vs  Mubritinib 0.2μM R01 exp48">
{{:chemogenomics:comparison_plots:exp450_vs_exp48.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Artemisinin 50μM R08 exp450  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp21_vs_exp450.png?nolink |}}
</modal>

<modal id="33" size="lg" title="Artemisinin 50μM R08 exp450  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp450_vs_exp80.png?nolink |}}
</modal>

<modal id="34" size="lg" title="Artemisinin 50μM R08 exp450  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp450.png?nolink |}}
</modal>

<modal id="35" size="lg" title="Artemisinin 50μM R08 exp450  vs  Dynasore 10μM R04 exp180">
{{:chemogenomics:comparison_plots:exp180_vs_exp450.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Artemisinin 50μM R08 exp450  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp450.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Artemisinin 50μM R08 exp450  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp450_vs_exp524.png?nolink |}}
</modal>

<modal id="38" size="lg" title="Artemisinin 50μM R08 exp450  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp356_vs_exp450.png?nolink |}}
</modal>

<modal id="39" size="lg" title="Artemisinin 50μM R08 exp450  vs  LY2090314 0.003μM R08 exp499">
{{:chemogenomics:comparison_plots:exp450_vs_exp499.png?nolink |}}
</modal>

<modal id="40" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp440_vs_exp450.png?nolink |}}
</modal>

<modal id="41" size="lg" title="AICAR 240μM R05 exp211  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp211_vs_exp450.png?nolink |}}
</modal>

<modal id="42" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp448_vs_exp450.png?nolink |}}
</modal>

<modal id="43" size="lg" title="AICAR 240μM R03 exp116  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp116_vs_exp450.png?nolink |}}
</modal>

<modal id="44" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp259_vs_exp450.png?nolink |}}
</modal>

<modal id="45" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp214_vs_exp450.png?nolink |}}
</modal>

<modal id="46" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp2_vs_exp450.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|GATOR1 complex|591.75|NPRL2,NPRL3|
|regulation of mitochondrial transcription|295.88|PRKAA1,THAP11|
|Seh1-associated complex|253.61|NPRL2,NPRL3,DEPDC5|
|proteasome core complex|93.43|PSMB8,PSMA3,PSMA2|
|negative regulation of TORC1 signaling|86.60|PRKAA1,NPRL2,NPRL3,ITFG2,DEPDC5,UBE2N|
|heme biosynthetic process|71.01|ABCB10,NFE2L1,SLC25A39|
|porphyrin-containing compound biosynthetic process|63.40|ABCB10,NFE2L1,SLC25A39|
|tetrapyrrole biosynthetic process|63.40|ABCB10,NFE2L1,SLC25A39|
|negative regulation of TOR signaling|53.80|PRKAA1,NPRL2,NPRL3,ITFG2,DEPDC5,UBE2N|
|proteasome complex|49.31|PSMB8,PSMD2,PSMD1,PSMA3,PSMA2|
|cellular response to amino acid starvation|49.31|NPRL2,NPRL3,ITFG2,DEPDC5|
|response to amino acid starvation|46.41|NPRL2,NPRL3,ITFG2,DEPDC5|
|regulation of TORC1 signaling|41.28|PRKAA1,NPRL2,NPRL3,ITFG2,DEPDC5,UBE2N|
|endopeptidase complex|35.22|PSMB8,PSMD2,PSMD1,PSMA3,PSMA2|
|regulation of TOR signaling|26.30|PRKAA1,NPRL2,NPRL3,ITFG2,DEPDC5,UBE2N|
|peptidase complex|24.86|PSMB8,PSMD2,PSMD1,PSMA3,PSMA2|
|cellular response to starvation|17.30|PRKAA1,NPRL2,NPRL3,ITFG2,DEPDC5|
|proteasomal protein catabolic process|10.90|PSMB8,NGLY1,PSMD2,PSMD1,PSMA3,UBE2N,PSMA2|
|negative regulation of intracellular signal transduction|9.25|PRKAA1,NPRL2,NPRL3,ITFG2,DEPDC5,UBE2N,DDX3X,THBS1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|protoporphyrinogen IX biosynthetic process|414.23|HMBS,PPOX,ALAD,ALAS1,CPOX,UROS|
|protoporphyrinogen IX metabolic process|386.61|HMBS,PPOX,ALAD,ALAS1,FECH,CPOX,UROS|
|porphyrin-containing compound biosynthetic process|177.53|HMBS,PPOX,ALAD,ALAS1,SUCLA2,FECH,CPOX,UROS,IBA57|
|tetrapyrrole biosynthetic process|157.80|HMBS,PPOX,ALAD,ALAS1,SUCLA2,FECH,UROS,IBA57|
|heme biosynthetic process|154.64|HMBS,PPOX,ALAD,ALAS1,FECH,CPOX,IBA57|
|heme metabolic process|113.29|HMBS,PPOX,ALAD,ALAS1,FECH,CPOX,UROS,IBA57|
|porphyrin-containing compound metabolic process|108.06|HMBS,PPOX,ALAD,ALAS1,SUCLA2,FECH,CPOX,UROS,IBA57|
|pigment biosynthetic process|107.77|HMBS,PPOX,ALAD,ALAS1,FECH,CPOX,UROS,IBA57|
|tetrapyrrole metabolic process|92.05|HMBS,PPOX,ALAD,ALAS1,SUCLA2,FECH,CPOX,UROS,IBA57|
|iron-sulfur cluster assembly|81.82|GLRX5,IBA57,NFU1,NUBPL|
|metallo-sulfur cluster assembly|81.82|GLRX5,IBA57,NFU1,NUBPL|
|pigment metabolic process|69.04|HMBS,PPOX,ALAD,ALAS1,FECH,CPOX,UROS,IBA57|
|metal cluster binding|41.22|GLRX5,FECH,NFU1,NUBPL,NDUFS2|
|iron-sulfur cluster binding|41.22|GLRX5,FECH,NFU1,NUBPL,NDUFS2|
|sulfur compound metabolic process|13.19|GLRX5,SUCLA2,SUCLG1,IBA57,NFU1,NUBPL,TPK1|
|mitochondrial matrix|11.65|ALAS1,GLRX5,SUCLA2,FECH,SUCLG1,MIPEP,IBA57,NUBPL,GRSF1,NDUFS2|
|ribonucleotide metabolic process|11.47|SUCLA2,SUCLG1,NDUFB9,NDUFB11,RFK,ATIC,NDUFS2|
|heterocycle biosynthetic process|10.42|HMBS,PPOX,ALAD,ALAS1,SUCLA2,FECH,PDXK,CPOX,UROS,NDUFB9,IBA57,NDUFB11,RFK,TPK1,ENY2,ATIC,NDUFS2|
|aromatic compound biosynthetic process|10.33|HMBS,PPOX,ALAD,ALAS1,SUCLA2,FECH,PDXK,CPOX,UROS,NDUFB9,IBA57,NDUFB11,RFK,TPK1,ENY2,ATIC,NDUFS2|
</modal>