====== Benzoate 20000μM R08 exp456 ====== ==== Mechanism of Action ==== Food additive (E211), bacteriostatic and fungistatic * **Class / Subclass 1:** Environmental Stresses / Food Preservative ==== Technical Notes ==== * **PubChem Name:** %%Sodium benzoate%% * **Synonyms:** N/A * **CAS #:** 532-32-1 * **PubChem CID:** [[https://pubchem.ncbi.nlm.nih.gov/compound/517055|517055]] * **IUPAC:** %%sodium;benzoate%% * **INCHI Name:** InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1 * **INCHI Key:** WXMKPNITSTVMEF-UHFFFAOYSA-M * **Molecular Weight:** 144.1 * **Canonical SMILES:** C1=CC=C(C=C1)C(=O)[O-].[Na+] * **Isomeric SMILES:** N/A * **Molecular Formula:** C7H5O2Na {{:chemogenomics:structures:chem-0266.svg?nolink}} * **Supplier Name:** Med Chem Express * **Catalog #:** HY-Y1316 * **Lot #:** 26735 * **HRMS (ESI-TOF) m/z:** (M+Na)+ Calcd for C7H6O2 145.026; found 145.02692 * **Platform ID:** Benzoate * **Min:** -0.6897; **Max:** 28.0815 {{:chemogenomics:dose_response:dr_503.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |N/A | | IC20 |N/A | | IC30 |N/A | | IC40 |N/A | | IC50 |N/A | | IC60 |N/A | | IC70 |N/A | | IC80 |N/A | | IC90 |N/A | \\ ==== Screen Summary ==== * **Round**: 08 * **Dose**: 20000µM * **Days of incubation**: 8 * **Doublings**: -0.0 * **Numbers of reads**: 15983785 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |0/63|[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Benzoate_20000uM_Round-8_exp456.txt|Scores]]|||||| {{:chemogenomics:cranks_plots:exp456.png?nolink}} ^Gene^CRANKS Score^FDR^ |[[:human_genes:L:LHFP|LHFP]]|-2.62|0.20| |[[:human_genes:H:HMGCR|HMGCR]]|-2.45|0.53| |[[:human_genes:E:EXOSC3|EXOSC3]]|-2.40|0.28| |[[:human_genes:D:DNM2|DNM2]]|-2.38|0.67| |[[:human_genes:M:METTL13|METTL13]]|-2.36|0.22| |[[:human_genes:Z:ZNF106|ZNF106]]|-2.34|0.22| |[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.33|0.22| |[[:human_genes:C:CCIN|CCIN]]|-2.33|0.22| |[[:human_genes:N:NFS1|NFS1]]|-2.31|0.67| |[[:human_genes:G:GTF2B|GTF2B]]|-2.27|0.65| |[[:human_genes:P:PPM1G|PPM1G]]|-2.26|0.37| |[[:human_genes:S:SYNCRIP|SYNCRIP]]|-2.26|0.53| |[[:human_genes:S:SUPT6H|SUPT6H]]|-2.21|0.53| |[[:human_genes:Z:ZDHHC2|ZDHHC2]]|-2.21|0.32| |[[:human_genes:L:LOC81691|LOC81691]]|-2.19|0.53| |[[:human_genes:N:NID2|NID2]]|-2.17|0.34| |[[:human_genes:S:SH3BP1|SH3BP1]]|-2.12|0.53| |[[:human_genes:P:PNPLA2|PNPLA2]]|-2.12|0.37| |[[:human_genes:C:COL2A1|COL2A1]]|-2.08|0.53| |[[:human_genes:P:PHF15|PHF15]]|-2.03|0.53| |[[:human_genes:M:MEF2D|MEF2D]]|-2.03|0.53| |[[:human_genes:C:CNOT3|CNOT3]]|-2.02|0.61| |[[:human_genes:V:VPREB1|VPREB1]]|-2.02|0.53| |[[:human_genes:R:RPS23|RPS23]]|-2.01|0.53| |[[:human_genes:N:NUP43|NUP43]]|-2.01|0.53| |[[:human_genes:S:SMG5|SMG5]]|-1.99|0.75| |[[:human_genes:P:PSKH1|PSKH1]]|-1.98|0.53| |[[:human_genes:M:MAU2|MAU2]]|-1.97|0.75| |[[:human_genes:K:KIAA1549|KIAA1549]]|-1.96|0.53| |[[:human_genes:S:SF3A1|SF3A1]]|-1.95|0.67| |[[:human_genes:M:MAPKAPK5|MAPKAPK5]]|2.96|<0.01| |[[:human_genes:S:SLC4A7|SLC4A7]]|2.96|<0.01| |[[:human_genes:C:CD19|CD19]]|2.98|<0.01| |[[:human_genes:K:KCTD5|KCTD5]]|2.99|0.00| |[[:human_genes:D:DOHH|DOHH]]|2.99|<0.01| |[[:human_genes:H:HCCS|HCCS]]|3.02|<0.01| |[[:human_genes:A:ALAS1|ALAS1]]|3.12|<0.01| |[[:human_genes:F:FLCN|FLCN]]|3.14|0.00| |[[:human_genes:C:CD81|CD81]]|3.15|0.00| |[[:human_genes:T:THG1L|THG1L]]|3.19|0.00| |[[:human_genes:L:LAMTOR4|LAMTOR4]]|3.30|0.00| |[[:human_genes:M:MLST8|MLST8]]|3.32|0.00| |[[:human_genes:B:BCL2L11|BCL2L11]]|3.40|0.00| |[[:human_genes:T:TAF4|TAF4]]|3.45|0.00| |[[:human_genes:G:GMPPB|GMPPB]]|3.70|<0.01| |[[:human_genes:C:CASP9|CASP9]]|3.70|0.00| |[[:human_genes:R:RICTOR|RICTOR]]|3.90|0.00| |[[:human_genes:M:MS4A13|MS4A13]]|3.91|0.02| |[[:human_genes:G:GNAS|GNAS]]|3.96|0.00| |[[:human_genes:M:MAPKAP1|MAPKAP1]]|4.04|0.00| |[[:human_genes:M:MCL1|MCL1]]|4.44|0.00| |[[:human_genes:A:APAF1|APAF1]]|4.55|0.00| |[[:human_genes:P:PLAA|PLAA]]|4.69|0.00| |[[:human_genes:A:AHCYL1|AHCYL1]]|5.07|0.00| |[[:human_genes:N:NSD1|NSD1]]|5.07|0.00| |[[:human_genes:F:FAF2|FAF2]]|5.36|0.00| |[[:human_genes:V:VDAC2|VDAC2]]|6.41|0.00| |[[:human_genes:U:UBQLN1|UBQLN1]]|6.91|0.00| |[[:human_genes:B:BAK1|BAK1]]|7.87|0.00| |[[:human_genes:M:MARCH5|MARCH5]]|7.88|0.00| ^Screen^Correlation^Plot^ |[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.166|| |[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.162|| |[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.156|| |[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.149|| |[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.142|| |[[:results:exp135|MS023 7μM R03 exp135]]|0.139|| |[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.137|| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.136|| |[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.132|| |[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.13|| |[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.122|| |[[:results:exp443|SNS-032 15μM R08 exp443]]|0.117|| |[[:results:exp512|Olaparib 4μM R08 exp512]]|0.113|| |[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.111|| |[[:results:exp134|MS023 2μM R03 exp134]]|0.108|| |[[:results:exp34|Rotenone 20μM R00 exp34]]|0.107|| |[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.103|| |[[:results:exp485|GSK626616 14μM R08 exp485]]|0.101|| |[[:results:exp19|Etoposide 1μM R00 exp19]]|0.1|| |[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.097|| |[[:results:exp515|PU-H71 1μM R08 exp515]]|0.095|| |[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.086|| |[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.085|| |[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.084|| |[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.083|| |[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.082|| |[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.079|| |[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.078|| |[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.075|| |[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.072|| |[[:results:exp85|UM0129480 7μM R02 exp85]]|0.07|| |[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.068|| |[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.066|| |[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.065|| |[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.059|| |[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.059|| |[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.058|| |[[:results:exp517|Quercetin 20μM R08 exp517]]|0.058|| |[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.057|| |[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.056|| |[[:results:exp93|DABN racemic mixture R03 exp93]]|0.055|| |[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.054|| |[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.052|| |[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.052|| |[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.051|| |[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.051|| |[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.16|| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.153|| |[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.152|| |[[:results:exp211|AICAR 240μM R05 exp211]]|0.128|| |[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.127|| |[[:results:exp116|AICAR 240μM R03 exp116]]|0.104|| |[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.096|| |[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.075|| |[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.072|| |[[:results:exp539|42°C R08 exp539]]|0.062|| {{:chemogenomics:comparison_plots:exp456_vs_exp459.png?nolink |}} {{:chemogenomics:comparison_plots:exp199_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp503.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp489.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp488.png?nolink |}} {{:chemogenomics:comparison_plots:exp135_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp80.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp531.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp524.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp472.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp478.png?nolink |}} {{:chemogenomics:comparison_plots:exp443_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp512.png?nolink |}} {{:chemogenomics:comparison_plots:exp28_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp134_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp34_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp355_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp485.png?nolink |}} {{:chemogenomics:comparison_plots:exp19_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp234_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp515.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp527.png?nolink |}} {{:chemogenomics:comparison_plots:exp357_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp474.png?nolink |}} {{:chemogenomics:comparison_plots:exp22_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp21_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp526.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp525.png?nolink |}} {{:chemogenomics:comparison_plots:exp435_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp529.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp85.png?nolink |}} {{:chemogenomics:comparison_plots:exp108_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp350_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp126_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp500.png?nolink |}} {{:chemogenomics:comparison_plots:exp106_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp498.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp517.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp468.png?nolink |}} {{:chemogenomics:comparison_plots:exp294_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp93.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp497.png?nolink |}} {{:chemogenomics:comparison_plots:exp354_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp374_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp535.png?nolink |}} {{:chemogenomics:comparison_plots:exp441_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp259_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp2_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp440_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp211_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp3_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp116_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp451_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp448_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp450_vs_exp456.png?nolink |}} {{:chemogenomics:comparison_plots:exp456_vs_exp539.png?nolink |}} No GO term hits below threshold. (FDR <0.05) ^GO Term^Fold Change^Genes^ |apoptosome|552.30|APAF1,CASP9| |activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|220.92|APAF1,CASP9| |TORC2 complex|207.11|MAPKAP1,RICTOR,MLST8| |Bcl-2 family protein complex|184.10|BAK1,MCL1,BCL2L11| |TOR signaling|78.90|MAPKAP1,RICTOR,MLST8,LAMTOR4,FLCN| |positive regulation of mitochondrial membrane permeability|59.18|BAK1,VDAC2,BCL2L11| |positive regulation of membrane permeability|53.45|BAK1,VDAC2,BCL2L11| |extrinsic apoptotic signaling pathway in absence of ligand|51.78|BAK1,MCL1,BCL2L11| |signal transduction in absence of ligand|51.78|BAK1,MCL1,BCL2L11| |apoptotic mitochondrial changes|39.45|BAK1,VDAC2,MCL1,BCL2L11| |intrinsic apoptotic signaling pathway in response to DNA damage|31.12|BAK1,MCL1,CASP9,BCL2L11| |intrinsic apoptotic signaling pathway|20.71|BAK1,APAF1,MCL1,CASP9,BCL2L11,FLCN| |regulation of TOR signaling|20.46|RICTOR,MLST8,LAMTOR4,FLCN,MAPKAPK5| |mitochondrial outer membrane|16.01|MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L| |regulation of intrinsic apoptotic signaling pathway|15.96|UBQLN1,VDAC2,MCL1,BCL2L11,FLCN| |organelle outer membrane|14.10|MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L| |outer membrane|13.92|MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L| |apoptotic signaling pathway|12.55|BAK1,VDAC2,APAF1,MCL1,CASP9,BCL2L11,FLCN| |mitochondrial membrane|6.27|MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L,ALAS1,HCCS|