====== Bisphenol F 50μM R08 exp457 ======
==== Mechanism of Action ====
BPA analog and substitute, endocrine disrupter
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Industrial Chemical




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%4,4'-Methylenediphenol%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 620-92-8
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/12111|12111]]
    * **<color #00a2e8>IUPAC:</color>** %%4-[(4-hydroxyphenyl)methyl]phenol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C13H12O2/c14-12-5-1-10(2-6-12)9-11-3-7-13(15)8-4-11/h1-8,14-15H,9H2
    * **<color #00a2e8>INCHI Key:</color>** PXKLMJQFEQBVLD-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 200.23
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=CC=C1CC2=CC=C(C=C2)O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C13H12O2
{{:chemogenomics:structures:chem-0267.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Ark Pharm Inc.
    * **<color #00a2e8>Catalog #:</color>** AK122333
    * **<color #00a2e8>Lot #:</color>** WG0092170-160531001
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M-H)- Calcd for C13 H12 O2 199.07645; found 199.07755
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Bisphenol_F
    * **<color #00a2e8>Min:</color>** -11.8847; **<color #00a2e8>Max:</color>** 7.7151
{{:chemogenomics:dose_response:dr_418.png?nolink&500 |}}
\\ 
\\ 
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 50µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.5
    * **<color #00a2e8>Numbers of reads</color>**: 14290606


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|4/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Bisphenol_F_50uM_Round-8_exp457.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Bisphenol F 50μM R08 exp457'>
{{:chemogenomics:cranks_plots:exp457.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ALG9|ALG9]]|-3.72|<0.01|
|[[:human_genes:T:TMEM189|TMEM189]]|-2.97|<0.01|
|[[:human_genes:S:SCD|SCD]]|-2.93|0.03|
|[[:human_genes:V:VPS25|VPS25]]|-2.84|0.27|
|[[:human_genes:O:ORC3|ORC3]]|-2.64|0.04|
|[[:human_genes:T:TPRKB|TPRKB]]|-2.56|0.09|
|[[:human_genes:A:ACSL4|ACSL4]]|-2.52|0.10|
|[[:human_genes:K:KDSR|KDSR]]|-2.51|0.07|
|[[:human_genes:C:CAPRIN2|CAPRIN2]]|-2.46|0.07|
|[[:human_genes:Z:ZNF708|ZNF708]]|-2.46|0.15|
|[[:human_genes:T:TSSC1|TSSC1]]|-2.36|0.10|
|[[:human_genes:A:ADIPOR2|ADIPOR2]]|-2.33|0.10|
|[[:human_genes:A:ARL1|ARL1]]|-2.31|0.10|
|[[:human_genes:S:SCYL1|SCYL1]]|-2.30|0.15|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.30|0.22|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.29|0.11|
|[[:human_genes:F:FAF2|FAF2]]|-2.27|0.23|
|[[:human_genes:V:VPS52|VPS52]]|-2.22|0.51|
|[[:human_genes:S:SCNN1A|SCNN1A]]|-2.22|0.14|
|[[:human_genes:A:ALG12|ALG12]]|-2.20|0.14|
|[[:human_genes:T:TMEM189-UBE2V1|TMEM189-UBE2V1]]|-2.19|0.14|
|[[:human_genes:S:SURF4|SURF4]]|-2.19|0.14|
|[[:human_genes:C:COG5|COG5]]|-2.17|0.22|
|[[:human_genes:T:TMEM131|TMEM131]]|-2.16|0.22|
|[[:human_genes:D:DNAJC3|DNAJC3]]|-2.15|0.15|
|[[:human_genes:T:TRPM8|TRPM8]]|-2.11|0.23|
|[[:human_genes:C:C2orf53|C2orf53]]|-2.11|0.18|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.10|0.23|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.09|0.49|
|[[:human_genes:R:RAD9A|RAD9A]]|-2.09|0.59|
|[[:human_genes:N:NFYB|NFYB]]|1.87|0.80|
|[[:human_genes:N:NIPBL|NIPBL]]|1.88|0.80|
|[[:human_genes:B:BRD8|BRD8]]|1.90|0.80|
|[[:human_genes:P:PSMD8|PSMD8]]|1.90|0.80|
|[[:human_genes:F:FZD1|FZD1]]|1.90|0.80|
|[[:human_genes:P:PI4KB|PI4KB]]|1.91|0.80|
|[[:human_genes:N:NRAP|NRAP]]|1.91|0.80|
|[[:human_genes:A:ANKRD24|ANKRD24]]|1.92|0.80|
|[[:human_genes:C:CDKN1C|CDKN1C]]|1.92|0.80|
|[[:human_genes:D:DENR|DENR]]|1.94|0.80|
|[[:human_genes:P:PRPF19|PRPF19]]|1.94|0.80|
|[[:human_genes:M:MGAT4D|MGAT4D]]|1.95|0.82|
|[[:human_genes:I:IQCC|IQCC]]|1.96|0.80|
|[[:human_genes:A:ANKRD40|ANKRD40]]|1.96|0.80|
|[[:human_genes:S:SHMT2|SHMT2]]|1.97|0.80|
|[[:human_genes:P:PSPC1|PSPC1]]|1.97|0.80|
|[[:human_genes:C:CYBA|CYBA]]|2.03|0.80|
|[[:human_genes:T:TPX2|TPX2]]|2.03|0.80|
|[[:human_genes:O:OR4M2|OR4M2]]|2.03|0.80|
|[[:human_genes:M:MAU2|MAU2]]|2.06|0.80|
|[[:human_genes:G:GAGE2A|GAGE2A]]|2.10|0.80|
|[[:human_genes:R:RERG|RERG]]|2.12|0.80|
|[[:human_genes:D:DDR2|DDR2]]|2.13|0.80|
|[[:human_genes:X:XPO1|XPO1]]|2.17|0.80|
|[[:human_genes:H:HSPA12B|HSPA12B]]|2.18|0.80|
|[[:human_genes:H:HIST1H2BL|HIST1H2BL]]|2.20|0.80|
|[[:human_genes:I:IK|IK]]|2.24|0.80|
|[[:human_genes:R:RPS4X|RPS4X]]|2.28|0.80|
|[[:human_genes:N:NATD1|NATD1]]|2.29|0.80|
|[[:human_genes:P:POLE2|POLE2]]|2.42|0.80|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.101|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.085|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.078|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.078|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|0.078|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.076|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.071|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|0.069|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.068|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|0.066|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.064|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|0.061|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|0.06|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|0.059|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|0.059|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.053|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|0.051|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|0.051|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.066|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.061|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.059|<button type="primary" size="small" modal="21">View</button>|
</modal>


<modal id="1" size="lg" title="Bisphenol F 50μM R08 exp457  vs  CCT251545 20μM R07 exp326">
{{:chemogenomics:comparison_plots:exp326_vs_exp457.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp457_vs_exp77.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Bisphenol F 50μM R08 exp457  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp457.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp457.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Trametinib 10μM R02 exp83">
{{:chemogenomics:comparison_plots:exp457_vs_exp83.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Bisphenol F 50μM R08 exp457  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp457_vs_exp483.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp457.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Bisphenol F 50μM R08 exp457  vs  ZLN024 50μM R08 exp538">
{{:chemogenomics:comparison_plots:exp457_vs_exp538.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp457_vs_exp530.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Bisphenol F 50μM R08 exp457  vs  MSC2530818 10μM R07 exp379">
{{:chemogenomics:comparison_plots:exp379_vs_exp457.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Bisphenol F 50μM R08 exp457  vs  NN-Dimethylsphingosine 2.5μM R08 exp508">
{{:chemogenomics:comparison_plots:exp457_vs_exp508.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Myriocin 25μM R06 exp293">
{{:chemogenomics:comparison_plots:exp293_vs_exp457.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Bisphenol F 50μM R08 exp457  vs  WNT3A 44ng/ml R08 exp537">
{{:chemogenomics:comparison_plots:exp457_vs_exp537.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Hydroxychloroquine 30μM R08 exp490">
{{:chemogenomics:comparison_plots:exp457_vs_exp490.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Nicotinamide 1000μM R03 exp101">
{{:chemogenomics:comparison_plots:exp101_vs_exp457.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp457.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp457_vs_exp47.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Momordin-Ic 10μM R08 exp506">
{{:chemogenomics:comparison_plots:exp457_vs_exp506.png?nolink |}}
</modal>

<modal id="19" size="lg" title="B02 10μM R08 exp453  vs  Bisphenol F 50μM R08 exp457">
{{:chemogenomics:comparison_plots:exp453_vs_exp457.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Bisphenol F 50μM R08 exp457">
{{:chemogenomics:comparison_plots:exp269_vs_exp457.png?nolink |}}
</modal>

<modal id="21" size="lg" title="BS-181 20μM R08 exp461  vs  Bisphenol F 50μM R08 exp457">
{{:chemogenomics:comparison_plots:exp457_vs_exp461.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|dolichol-linked oligosaccharide biosynthetic process|109.01|ALG9,ALG12,DPAGT1|
|oligosaccharide-lipid intermediate biosynthetic process|103.56|ALG9,ALG12,DPAGT1|
|phosphotransferase activity, for other substituted phosphate groups|98.62|CEPT1,DPAGT1,CDIPT|
|dolichol metabolic process|98.62|ALG9,ALG12,DPAGT1|
|polyprenol metabolic process|90.05|ALG9,ALG12,DPAGT1|
|endosomal transport|14.88|VPS25,EIPR1,ARL1,VPS52,SURF4|
|cellular lipid metabolic process|7.04|ALG9,SCD,ACSL4,KDSR,ADIPOR2,CEPT1,ALG12,DPAGT1,CDIPT|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>