====== CB-5083 0.4μM R08 exp468 ======
==== Mechanism of Action ====
Inhibits p97 AAA-ATPase
  * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / Unfoldase Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%CB-5083%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1542705-92-9
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/73051434|73051434]]
    * **<color #00a2e8>IUPAC:</color>** %%1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9,12H,10-11,13-14H2,1H3,(H2,25,30)(H,26,27,28)
    * **<color #00a2e8>INCHI Key:</color>** RDALZZCKQFLGJP-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 413.5
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=CC2=C(C=CC=C2N1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5)C(=O)N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C24H23N5O2
{{:chemogenomics:structures:chem-0277.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-12861
    * **<color #00a2e8>Lot #:</color>** 19554
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C24H23N5O2 414.19245; found 414.1939
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** CB5083
    * **<color #00a2e8>Min:</color>** -4.3018; **<color #00a2e8>Max:</color>** 99.5602
{{:chemogenomics:dose_response:dr_514.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.2207    |
| IC20  |0.3114    |
| IC30  |0.3915    |
| IC40  |0.4724    |
| IC50  |0.5612    |
| IC60  |0.6666    |
| IC70  |0.8043    |
| IC80  |1.0110    |
| IC90  |1.4270    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 400nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.5
    * **<color #00a2e8>Numbers of reads</color>**: 13284720


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|24/42|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/CB-5083_0.4uM_Round-8_exp468.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='CB-5083 0.4μM R08 exp468'>
{{:chemogenomics:cranks_plots:exp468.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:U:UBXN1|UBXN1]]|-4.71|<0.01|
|[[:human_genes:P:PLAA|PLAA]]|-4.48|<0.01|
|[[:human_genes:A:ADK|ADK]]|-4.02|<0.01|
|[[:human_genes:D:DDI2|DDI2]]|-3.76|<0.01|
|[[:human_genes:S:SRF|SRF]]|-3.74|<0.01|
|[[:human_genes:D:DERL1|DERL1]]|-3.37|<0.01|
|[[:human_genes:N:NGLY1|NGLY1]]|-3.35|<0.01|
|[[:human_genes:N:NPRL2|NPRL2]]|-3.13|<0.01|
|[[:human_genes:B:BCL2L1|BCL2L1]]|-3.10|<0.01|
|[[:human_genes:Z:ZBTB10|ZBTB10]]|-2.87|<0.01|
|[[:human_genes:D:DDX54|DDX54]]|-2.82|0.02|
|[[:human_genes:C:CHMP2A|CHMP2A]]|-2.74|0.06|
|[[:human_genes:N:NPLOC4|NPLOC4]]|-2.73|0.03|
|[[:human_genes:M:MBTD1|MBTD1]]|-2.68|0.01|
|[[:human_genes:A:ASPSCR1|ASPSCR1]]|-2.57|0.02|
|[[:human_genes:N:NSFL1C|NSFL1C]]|-2.55|0.02|
|[[:human_genes:R:RAD23B|RAD23B]]|-2.54|0.03|
|[[:human_genes:M:MTMR4|MTMR4]]|-2.53|0.02|
|[[:human_genes:S:SOX4|SOX4]]|-2.51|0.07|
|[[:human_genes:C:CSK|CSK]]|-2.50|0.02|
|[[:human_genes:R:RANBP1|RANBP1]]|-2.49|0.02|
|[[:human_genes:C:CDK1|CDK1]]|-2.48|0.07|
|[[:human_genes:S:SYS1|SYS1]]|-2.45|0.08|
|[[:human_genes:C:CCL16|CCL16]]|-2.42|0.06|
|[[:human_genes:D:DRD2|DRD2]]|-2.42|0.03|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.42|0.09|
|[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.41|0.03|
|[[:human_genes:C:COG7|COG7]]|-2.40|0.03|
|[[:human_genes:D:DERL2|DERL2]]|-2.35|0.07|
|[[:human_genes:Z:ZNF296|ZNF296]]|-2.35|0.04|
|[[:human_genes:C:CCNL1|CCNL1]]|2.56|0.01|
|[[:human_genes:R:ROMO1|ROMO1]]|2.58|0.04|
|[[:human_genes:E:EBF1|EBF1]]|2.67|0.03|
|[[:human_genes:F:FAM98B|FAM98B]]|2.67|0.01|
|[[:human_genes:U:USP14|USP14]]|2.70|<0.01|
|[[:human_genes:Y:YLPM1|YLPM1]]|2.75|0.04|
|[[:human_genes:N:NUDT5|NUDT5]]|2.78|<0.01|
|[[:human_genes:R:RPTOR|RPTOR]]|2.83|<0.01|
|[[:human_genes:P:PCIF1|PCIF1]]|2.86|<0.01|
|[[:human_genes:D:DPH5|DPH5]]|2.86|<0.01|
|[[:human_genes:T:THRAP3|THRAP3]]|2.87|<0.01|
|[[:human_genes:S:SLC7A1|SLC7A1]]|2.89|0.03|
|[[:human_genes:U:UBR2|UBR2]]|2.92|<0.01|
|[[:human_genes:T:THRA|THRA]]|2.92|<0.01|
|[[:human_genes:S:SCAP|SCAP]]|3.00|<0.01|
|[[:human_genes:I:IKZF1|IKZF1]]|3.17|0.00|
|[[:human_genes:U:UBA6|UBA6]]|3.22|0.00|
|[[:human_genes:D:DAZAP1|DAZAP1]]|3.25|0.00|
|[[:human_genes:S:SRM|SRM]]|3.36|0.00|
|[[:human_genes:U:UBE2Z|UBE2Z]]|3.37|0.00|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|3.39|0.00|
|[[:human_genes:R:RPS25|RPS25]]|3.41|0.00|
|[[:human_genes:S:SLC39A10|SLC39A10]]|3.43|0.00|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.57|0.00|
|[[:human_genes:D:DPH6|DPH6]]|3.64|0.00|
|[[:human_genes:C:CNBP|CNBP]]|3.73|0.00|
|[[:human_genes:I:IKZF2|IKZF2]]|3.93|0.00|
|[[:human_genes:T:TPT1|TPT1]]|4.13|0.00|
|[[:human_genes:T:TRIP12|TRIP12]]|4.80|0.00|
|[[:human_genes:I:IMPDH2|IMPDH2]]|5.59|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.084|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.083|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.08|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.079|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.078|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.075|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.074|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.073|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.071|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.07|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.068|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.068|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.066|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.066|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.062|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.061|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.061|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.06|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.06|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.059|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.059|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.059|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.058|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.058|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.057|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.055|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.055|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.055|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.055|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.054|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|0.054|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.053|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.053|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.051|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.051|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|0.076|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.071|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.069|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.061|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.058|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.057|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|0.056|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|0.055|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.055|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.053|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|0.052|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.051|<button type="primary" size="small" modal="47">View</button>|
</modal>


<modal id="1" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp468_vs_exp478.png?nolink |}}
</modal>

<modal id="2" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp468_vs_exp502.png?nolink |}}
</modal>

<modal id="3" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp468_vs_exp529.png?nolink |}}
</modal>

<modal id="4" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp468_vs_exp488.png?nolink |}}
</modal>

<modal id="5" size="lg" title="CB-5083 0.4μM R08 exp468  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp468.png?nolink |}}
</modal>

<modal id="6" size="lg" title="CB-5083 0.4μM R08 exp468  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp21_vs_exp468.png?nolink |}}
</modal>

<modal id="7" size="lg" title="CB-5083 0.4μM R08 exp468  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp468_vs_exp515.png?nolink |}}
</modal>

<modal id="8" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp234_vs_exp468.png?nolink |}}
</modal>

<modal id="9" size="lg" title="CB-5083 0.4μM R08 exp468  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp468.png?nolink |}}
</modal>

<modal id="10" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp468_vs_exp489.png?nolink |}}
</modal>

<modal id="11" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp468_vs_exp525.png?nolink |}}
</modal>

<modal id="12" size="lg" title="CB-5083 0.4μM R08 exp468  vs  LLY-283 2.6μM R06 exp290">
{{:chemogenomics:comparison_plots:exp290_vs_exp468.png?nolink |}}
</modal>

<modal id="13" size="lg" title="CB-5083 0.4μM R08 exp468  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp468.png?nolink |}}
</modal>

<modal id="14" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp468_vs_exp524.png?nolink |}}
</modal>

<modal id="15" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp416_vs_exp468.png?nolink |}}
</modal>

<modal id="16" size="lg" title="CB-5083 0.4μM R08 exp468  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp468_vs_exp485.png?nolink |}}
</modal>

<modal id="17" size="lg" title="CB-5083 0.4μM R08 exp468  vs  LY2090314 0.003μM R08 exp500 no dilution day6">
{{:chemogenomics:comparison_plots:exp468_vs_exp500.png?nolink |}}
</modal>

<modal id="18" size="lg" title="CB-5083 0.4μM R08 exp468  vs  ML-792 0.2μM R08 exp505">
{{:chemogenomics:comparison_plots:exp468_vs_exp505.png?nolink |}}
</modal>

<modal id="19" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp468_vs_exp512.png?nolink |}}
</modal>

<modal id="20" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp468_vs_exp526.png?nolink |}}
</modal>

<modal id="21" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp468.png?nolink |}}
</modal>

<modal id="22" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp466_vs_exp468.png?nolink |}}
</modal>

<modal id="23" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp294_vs_exp468.png?nolink |}}
</modal>

<modal id="24" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Thapsigargin 0.005μM R07 exp407">
{{:chemogenomics:comparison_plots:exp407_vs_exp468.png?nolink |}}
</modal>

<modal id="25" size="lg" title="CB-5083 0.4μM R08 exp468  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp468_vs_exp474.png?nolink |}}
</modal>

<modal id="26" size="lg" title="CB-5083 0.4μM R08 exp468  vs  LY2090314 0.003μM R08 exp499">
{{:chemogenomics:comparison_plots:exp468_vs_exp499.png?nolink |}}
</modal>

<modal id="27" size="lg" title="CB-5083 0.4μM R08 exp468  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp468_vs_exp80.png?nolink |}}
</modal>

<modal id="28" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp468.png?nolink |}}
</modal>

<modal id="29" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Latrunculin-B 10μM R07 exp374">
{{:chemogenomics:comparison_plots:exp374_vs_exp468.png?nolink |}}
</modal>

<modal id="30" size="lg" title="CB-5083 0.4μM R08 exp468  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp468_vs_exp85.png?nolink |}}
</modal>

<modal id="31" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp468.png?nolink |}}
</modal>

<modal id="32" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp357_vs_exp468.png?nolink |}}
</modal>

<modal id="33" size="lg" title="CB-5083 0.4μM R08 exp468  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp435_vs_exp468.png?nolink |}}
</modal>

<modal id="34" size="lg" title="CB-5083 0.4μM R08 exp468  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp468_vs_exp84.png?nolink |}}
</modal>

<modal id="35" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp350_vs_exp468.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Bortezomib 0.005μM R00 exp6  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp468_vs_exp6.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp440_vs_exp468.png?nolink |}}
</modal>

<modal id="38" size="lg" title="Artemisinin 50μM R08 exp450  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp450_vs_exp468.png?nolink |}}
</modal>

<modal id="39" size="lg" title="Bleomycin 5μM R08 exp459  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp459_vs_exp468.png?nolink |}}
</modal>

<modal id="40" size="lg" title="BVD-523 15μM R02 exp67  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp468_vs_exp67.png?nolink |}}
</modal>

<modal id="41" size="lg" title="Benzoate 20000μM R08 exp456  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp456_vs_exp468.png?nolink |}}
</modal>

<modal id="42" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp214_vs_exp468.png?nolink |}}
</modal>

<modal id="43" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp334_vs_exp468.png?nolink |}}
</modal>

<modal id="44" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp3_vs_exp468.png?nolink |}}
</modal>

<modal id="45" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp259_vs_exp468.png?nolink |}}
</modal>

<modal id="46" size="lg" title="Arsenate 40μM R06 exp264  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp264_vs_exp468.png?nolink |}}
</modal>

<modal id="47" size="lg" title="AICAR 240μM R05 exp211  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp211_vs_exp468.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|GATOR1 complex|571.34|NPRL2,NPRL3|
|Hrd1p ubiquitin ligase ERAD-L complex|228.54|DERL1,DERL2|
|endoplasmic reticulum to cytosol transport|100.83|DERL1,NPLOC4,DERL2|
|retrograde protein transport, ER to cytosol|100.83|DERL1,NPLOC4,DERL2|
|protein exit from endoplasmic reticulum|63.48|DERL1,NPLOC4,DERL2|
|aorta morphogenesis|55.29|SRF,SOX4,NPRL3|
|ubiquitin binding|34.63|UBXN1,PLAA,DDI2,NPLOC4,NSFL1C,RAD23B|
|ubiquitin-like protein binding|29.05|UBXN1,PLAA,DDI2,NPLOC4,NSFL1C,RAD23B|
|ERAD pathway|23.56|DERL1,NGLY1,NPLOC4,DERL2|
|negative regulation of protein localization|14.00|BCL2L1,NSFL1C,CSK,DRD2,DERL2|
|proteasomal protein catabolic process|13.53|UBXN1,PLAA,DDI2,DERL1,NGLY1,NPLOC4,NSFL1C,RAD23B,DERL2|
|positive regulation of growth|11.85|PLAA,SRF,CDK1,DRD2,DERL2|
|proteasome-mediated ubiquitin-dependent protein catabolic process|11.59|UBXN1,PLAA,DERL1,NPLOC4,NSFL1C,RAD23B,DERL2|
|proteolysis involved in protein catabolic process|9.80|UBXN1,PLAA,DDI2,DERL1,NGLY1,CHMP2A,NPLOC4,NSFL1C,RAD23B,DERL2|
|ubiquitin-dependent protein catabolic process|8.94|UBXN1,PLAA,DERL1,CHMP2A,NPLOC4,NSFL1C,RAD23B,DERL2|
|modification-dependent protein catabolic process|8.77|UBXN1,PLAA,DERL1,CHMP2A,NPLOC4,NSFL1C,RAD23B,DERL2|
|modification-dependent macromolecule catabolic process|8.59|UBXN1,PLAA,DERL1,CHMP2A,NPLOC4,NSFL1C,RAD23B,DERL2|
|protein catabolic process|8.22|UBXN1,PLAA,DDI2,DERL1,NGLY1,CHMP2A,NPLOC4,NSFL1C,RAD23B,DERL2|
|macromolecule catabolic process|6.20|UBXN1,PLAA,DDI2,DERL1,NGLY1,CHMP2A,NPLOC4,NSFL1C,RAD23B,DERL2|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>