====== Lapatinib 5μM R01 exp47 ======
==== Mechanism of Action ====
Inhibits EGFR and ErbB2 receptor tyrosine kinases
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Kinase Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Lapatinib Ditosylate%%
    * **<color #00a2e8>Synonyms:</color>** GW-572016 ditosylate
    * **<color #00a2e8>CAS #:</color>** 388082-77-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/9941095|9941095]]
    * **<color #00a2e8>IUPAC:</color>** %%N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10)
    * **<color #00a2e8>INCHI Key:</color>** UWYXLGUQQFPJRI-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 925.5
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C43H42ClFN4O10S3
{{:chemogenomics:structures:chem-0027.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Selleck Chemicals
    * **<color #00a2e8>Catalog #:</color>** S1028
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C29H26ClFN4O4S 581.14201; found 581.14334
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** LAPATINIB-DITOSYLATE
    * **<color #00a2e8>Min:</color>** -5.2045; **<color #00a2e8>Max:</color>** 27.8224
{{:chemogenomics:dose_response:dr_89.png?nolink&500 |}}
\\ 
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\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |6.4969    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 01
    * **<color #00a2e8>Dose</color>**: 5µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.2
    * **<color #00a2e8>Numbers of reads</color>**: 14927766


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|9/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Lapatinib_5uM_Round-1_exp47.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Lapatinib 5μM R01 exp47'>
{{:chemogenomics:cranks_plots:exp47.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:F:FLVCR1|FLVCR1]]|-4.44|<0.01|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-4.19|<0.01|
|[[:human_genes:S:SPTLC2|SPTLC2]]|-4.08|<0.01|
|[[:human_genes:S:SUGT1|SUGT1]]|-3.95|0.02|
|[[:human_genes:C:CEPT1|CEPT1]]|-3.65|<0.01|
|[[:human_genes:S:SPTLC1|SPTLC1]]|-3.13|0.01|
|[[:human_genes:F:FARSB|FARSB]]|-3.11|0.09|
|[[:human_genes:G:GPR107|GPR107]]|-3.04|0.02|
|[[:human_genes:H:HEPN1|HEPN1]]|-2.98|0.01|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.88|0.08|
|[[:human_genes:V:VPS25|VPS25]]|-2.65|0.33|
|[[:human_genes:C:CHKA|CHKA]]|-2.64|0.02|
|[[:human_genes:E:EDAR|EDAR]]|-2.52|0.08|
|[[:human_genes:P:PRRC1|PRRC1]]|-2.49|0.36|
|[[:human_genes:C:CHGB|CHGB]]|-2.47|0.36|
|[[:human_genes:S:SLC7A5|SLC7A5]]|-2.45|0.19|
|[[:human_genes:L:LINC00452|LINC00452]]|-2.41|0.21|
|[[:human_genes:T:TBC1D31|TBC1D31]]|-2.39|0.21|
|[[:human_genes:D:DAD1|DAD1]]|-2.36|0.15|
|[[:human_genes:H:HAPLN4|HAPLN4]]|-2.35|0.42|
|[[:human_genes:C:C10orf76|C10orf76]]|-2.34|0.34|
|[[:human_genes:A:ALG1L2|ALG1L2]]|-2.34|0.34|
|[[:human_genes:R:RGS7|RGS7]]|-2.33|0.44|
|[[:human_genes:W:WDR82|WDR82]]|-2.31|0.36|
|[[:human_genes:U:UBA3|UBA3]]|-2.30|0.58|
|[[:human_genes:E:ERCC2|ERCC2]]|-2.29|0.36|
|[[:human_genes:S:SGMS1|SGMS1]]|-2.28|0.19|
|[[:human_genes:L:LIN9|LIN9]]|-2.27|0.49|
|[[:human_genes:P:PI4KB|PI4KB]]|-2.26|0.33|
|[[:human_genes:C:CCT6A|CCT6A]]|-2.25|0.37|
|[[:human_genes:G:GNAS|GNAS]]|2.19|0.34|
|[[:human_genes:M:METTL1|METTL1]]|2.21|0.45|
|[[:human_genes:S:SLC47A1|SLC47A1]]|2.22|0.52|
|[[:human_genes:C:C1orf95|C1orf95]]|2.23|0.34|
|[[:human_genes:P:PSMB3|PSMB3]]|2.23|0.52|
|[[:human_genes:N:NUP155|NUP155]]|2.25|0.52|
|[[:human_genes:U:U2AF2|U2AF2]]|2.28|0.47|
|[[:human_genes:A:AAAS|AAAS]]|2.30|0.45|
|[[:human_genes:T:TAF15|TAF15]]|2.31|0.45|
|[[:human_genes:C:CEP89|CEP89]]|2.32|0.43|
|[[:human_genes:T:TTK|TTK]]|2.33|0.52|
|[[:human_genes:Z:ZNF114|ZNF114]]|2.35|0.45|
|[[:human_genes:E:EIF3A|EIF3A]]|2.37|0.52|
|[[:human_genes:R:RALGDS|RALGDS]]|2.39|0.50|
|[[:human_genes:T:TRIM52|TRIM52]]|2.39|0.55|
|[[:human_genes:A:ARID4B|ARID4B]]|2.41|0.34|
|[[:human_genes:R:RAD51|RAD51]]|2.49|0.58|
|[[:human_genes:P:POLA2|POLA2]]|2.51|0.45|
|[[:human_genes:U:USP37|USP37]]|2.58|0.34|
|[[:human_genes:C:CDC73|CDC73]]|2.65|0.50|
|[[:human_genes:H:HK2|HK2]]|2.66|0.34|
|[[:human_genes:R:RBM26|RBM26]]|2.73|0.34|
|[[:human_genes:P:PSMA5|PSMA5]]|2.76|0.34|
|[[:human_genes:U:UBA52|UBA52]]|2.78|0.45|
|[[:human_genes:Y:YME1L1|YME1L1]]|2.78|0.35|
|[[:human_genes:I:IER3IP1|IER3IP1]]|2.82|0.45|
|[[:human_genes:A:ATF7IP|ATF7IP]]|2.85|0.34|
|[[:human_genes:T:TRIM44|TRIM44]]|3.06|0.34|
|[[:human_genes:S:SNRNP200|SNRNP200]]|3.12|0.34|
|[[:human_genes:T:THAP1|THAP1]]|3.45|0.26|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.083|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.071|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.069|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|0.063|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.06|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|0.057|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|0.054|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|0.051|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.076|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.057|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|0.056|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.054|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.054|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|0.053|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.052|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|0.051|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.051|<button type="primary" size="small" modal="17">View</button>|
</modal>


<modal id="1" size="lg" title="Lapatinib 5μM R01 exp47  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp47.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Lapatinib 5μM R01 exp47  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp47_vs_exp90.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Lapatinib 5μM R01 exp47  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp47.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Lapatinib 5μM R01 exp47  vs  ZLN024 50μM R08 exp538">
{{:chemogenomics:comparison_plots:exp47_vs_exp538.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Lapatinib 5μM R01 exp47  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp47.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Lapatinib 5μM R01 exp47  vs  YM155 0.0002μM R01 exp61">
{{:chemogenomics:comparison_plots:exp47_vs_exp61.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Lapatinib 5μM R01 exp47  vs  NFN1 0.1μM R01 exp49">
{{:chemogenomics:comparison_plots:exp47_vs_exp49.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Lapatinib 5μM R01 exp47  vs  Trametinib 10μM R02 exp83">
{{:chemogenomics:comparison_plots:exp47_vs_exp83.png?nolink |}}
</modal>

<modal id="9" size="lg" title="BS-181 20μM R08 exp461  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp461_vs_exp47.png?nolink |}}
</modal>

<modal id="10" size="lg" title="BH1 1μM R04 exp169  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp169_vs_exp47.png?nolink |}}
</modal>

<modal id="11" size="lg" title="BI-2536 0.001μM R01 exp41  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp41_vs_exp47.png?nolink |}}
</modal>

<modal id="12" size="lg" title="CCT251545 20μM R07 exp326  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp326_vs_exp47.png?nolink |}}
</modal>

<modal id="13" size="lg" title="EPZ-5676 30μM R05 exp233  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp233_vs_exp47.png?nolink |}}
</modal>

<modal id="14" size="lg" title="BRD2 inhibitor II 20μM R07 exp341  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp341_vs_exp47.png?nolink |}}
</modal>

<modal id="15" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp445_vs_exp47.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Cyclosporin-A 3μM R07 exp348  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp348_vs_exp47.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp457_vs_exp47.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|sphinganine metabolic process|636.73|SPTLC2,SPTLC1|
|C-palmitoyltransferase activity|318.37|SPTLC2,SPTLC1|
|positive regulation of lipophagy|318.37|SPTLC2,SPTLC1|
|regulation of lipophagy|318.37|SPTLC2,SPTLC1|
|CDP-choline pathway|318.37|CEPT1,PCYT1A,CHKA|
|serine C-palmitoyltransferase activity|318.37|SPTLC2,SPTLC1|
|sphingomyelin biosynthetic process|191.02|SPTLC2,SPTLC1,SGMS1|
|sphingomyelin metabolic process|106.12|SPTLC2,SPTLC1,SGMS1|
|phosphatidylcholine biosynthetic process|79.59|CEPT1,PCYT1A,CHKA|
|phospholipid biosynthetic process|19.13|SPTLC2,CEPT1,SPTLC1,PCYT1A,CHKA,SGMS1,PI4KB|
|phospholipid metabolic process|12.88|SPTLC2,CEPT1,SPTLC1,PCYT1A,CHKA,SGMS1,PI4KB|
|organophosphate biosynthetic process|8.60|SPTLC2,CEPT1,SPTLC1,PCYT1A,CHKA,SGMS1,PI4KB|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>