====== CR131-b 0.005μM R08 exp474 ======
==== Mechanism of Action ====
Inhibits EIF4A, blocks translation by trapping EIF4A on mRNA at poly-purine sites
  * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / Translation Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%(1R,2R,3S,3Ar,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1352914-52-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/56946209|56946209]]
    * **<color #00a2e8>IUPAC:</color>** %%(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C28H29NO8/c1-33-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(31)29-36-4)25(30)27(28,32)24-20(35-3)14-19(34-2)15-21(24)37-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** KLSIFOJPWJBRFH-GWNOIRNCSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 507.5
    * **<color #00a2e8>Canonical SMILES:</color>** COC1=CC=C(C=C1)C23C(C(C(C2(C4=C(O3)C=C(C=C4OC)OC)O)O)C(=O)NOC)C5=CC=CC=C5
    * **<color #00a2e8>Isomeric SMILES:</color>** COC1=CC=C(C=C1)[C@]23[C@@H]([C@H]([C@H]([C@]2(C4=C(O3)C=C(C=C4OC)OC)O)O)C(=O)NOC)C5=CC=CC=C5
    * **<color #00a2e8>Molecular Formula:</color>** C28H29NO8
{{:chemogenomics:structures:chem-0283.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** In house - McGill University - Jerry Pelletier group
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M-H)- Calcd for C28 H29 N O8 506.18204; found 506.18321
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** CR131B
    * **<color #00a2e8>Min:</color>** -2.5197; **<color #00a2e8>Max:</color>** 93.9504
{{:chemogenomics:dose_response:dr_521.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.0001    |
| IC20  |0.0006    |
| IC30  |0.0020    |
| IC40  |0.0051    |
| IC50  |0.0122    |
| IC60  |0.0293    |
| IC70  |0.0762    |
| IC80  |0.2443    |
| IC90  |1.4100    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 5nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.0
    * **<color #00a2e8>Numbers of reads</color>**: 19941458


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|3/44|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/CR131-b_0.005uM_Round-8_exp474.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='CR131-b 0.005μM R08 exp474'>
{{:chemogenomics:cranks_plots:exp474.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:N:NRAS|NRAS]]|-3.85|<0.01|
|[[:human_genes:N:NPRL3|NPRL3]]|-3.35|0.01|
|[[:human_genes:N:NSUN5|NSUN5]]|-2.84|0.08|
|[[:human_genes:Z:ZNF830|ZNF830]]|-2.68|0.04|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.51|0.08|
|[[:human_genes:N:NHP2L1|NHP2L1]]|-2.41|0.32|
|[[:human_genes:O:OTUB1|OTUB1]]|-2.41|0.19|
|[[:human_genes:C:CDK2|CDK2]]|-2.35|0.16|
|[[:human_genes:Y:YBX3|YBX3]]|-2.32|0.23|
|[[:human_genes:R:RHBDD3|RHBDD3]]|-2.29|0.19|
|[[:human_genes:D:DDX23|DDX23]]|-2.23|0.51|
|[[:human_genes:R:RPS28|RPS28]]|-2.23|0.40|
|[[:human_genes:C:CCM2|CCM2]]|-2.23|0.22|
|[[:human_genes:A:AURKB|AURKB]]|-2.20|0.51|
|[[:human_genes:D:DDX3X|DDX3X]]|-2.18|0.23|
|[[:human_genes:C:CDC73|CDC73]]|-2.16|0.30|
|[[:human_genes:G:GOLGA6L1|GOLGA6L1]]|-2.15|0.60|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|-2.15|0.25|
|[[:human_genes:L:LOC200726|LOC200726]]|-2.14|0.25|
|[[:human_genes:F:FIBP|FIBP]]|-2.12|0.26|
|[[:human_genes:S:SZT2|SZT2]]|-2.11|0.26|
|[[:human_genes:E:ESPL1|ESPL1]]|-2.10|0.37|
|[[:human_genes:C:CHRNB3|CHRNB3]]|-2.10|0.26|
|[[:human_genes:B:BCL2|BCL2]]|-2.09|0.26|
|[[:human_genes:B:BRCA1|BRCA1]]|-2.09|0.32|
|[[:human_genes:P:PSIP1|PSIP1]]|-2.08|0.26|
|[[:human_genes:S:SRSF3|SRSF3]]|-2.07|0.30|
|[[:human_genes:T:TLR9|TLR9]]|-2.05|0.29|
|[[:human_genes:M:MS4A13|MS4A13]]|-2.05|0.63|
|[[:human_genes:P:PRKCE|PRKCE]]|-2.04|0.29|
|[[:human_genes:S:SCD|SCD]]|2.56|0.02|
|[[:human_genes:N:N6AMT1|N6AMT1]]|2.59|0.07|
|[[:human_genes:I:INTS10|INTS10]]|2.62|<0.01|
|[[:human_genes:G:GNA13|GNA13]]|2.63|<0.01|
|[[:human_genes:M:MRPS5|MRPS5]]|2.65|0.01|
|[[:human_genes:F:FBXO11|FBXO11]]|2.67|<0.01|
|[[:human_genes:F:FECH|FECH]]|2.70|<0.01|
|[[:human_genes:B:BCL2L11|BCL2L11]]|2.77|<0.01|
|[[:human_genes:I:IKZF1|IKZF1]]|2.78|<0.01|
|[[:human_genes:G:GPATCH8|GPATCH8]]|2.83|<0.01|
|[[:human_genes:R:RABIF|RABIF]]|3.03|<0.01|
|[[:human_genes:C:COX7B|COX7B]]|3.03|<0.01|
|[[:human_genes:E:ELP6|ELP6]]|3.06|0.00|
|[[:human_genes:T:TP53|TP53]]|3.06|<0.01|
|[[:human_genes:D:DENND4A|DENND4A]]|3.21|<0.01|
|[[:human_genes:D:DAZAP1|DAZAP1]]|3.28|0.00|
|[[:human_genes:S:SF1|SF1]]|3.33|<0.01|
|[[:human_genes:I:IKZF2|IKZF2]]|3.41|0.00|
|[[:human_genes:P:PMAIP1|PMAIP1]]|3.44|0.00|
|[[:human_genes:K:KLF16|KLF16]]|3.49|0.00|
|[[:human_genes:V:VDAC2|VDAC2]]|3.76|0.00|
|[[:human_genes:C:CYCS|CYCS]]|4.07|0.00|
|[[:human_genes:A:ALAS1|ALAS1]]|4.29|0.00|
|[[:human_genes:C:CCAR1|CCAR1]]|4.29|0.00|
|[[:human_genes:M:MARCH5|MARCH5]]|4.36|0.00|
|[[:human_genes:C:CASP9|CASP9]]|4.44|0.00|
|[[:human_genes:A:APAF1|APAF1]]|4.47|0.00|
|[[:human_genes:H:HCCS|HCCS]]|4.62|0.00|
|[[:human_genes:B:BAK1|BAK1]]|7.44|0.00|
|[[:human_genes:E:EIF4A2|EIF4A2]]|7.88|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp135|MS023 7μM R03 exp135]]|0.101|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.095|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.093|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.091|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.089|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.088|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.084|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.082|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.08|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.079|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.079|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.078|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.077|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.076|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.076|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.075|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp532|TIC10 10μM R08 exp532]]|0.074|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.072|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.068|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|0.067|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.061|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|0.06|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.058|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.058|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.057|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.057|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|0.057|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.056|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.055|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.052|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|0.052|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.084|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.08|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.078|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.076|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.074|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.069|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.067|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.066|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.063|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|0.061|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.057|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.056|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.055|<button type="primary" size="small" modal="44">View</button>|
</modal>


<modal id="1" size="lg" title="CR131-b 0.005μM R08 exp474  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp474.png?nolink |}}
</modal>

<modal id="2" size="lg" title="CR131-b 0.005μM R08 exp474  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp474_vs_exp515.png?nolink |}}
</modal>

<modal id="3" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp474_vs_exp478.png?nolink |}}
</modal>

<modal id="4" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp474_vs_exp488.png?nolink |}}
</modal>

<modal id="5" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp474_vs_exp524.png?nolink |}}
</modal>

<modal id="6" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp474_vs_exp489.png?nolink |}}
</modal>

<modal id="7" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp474_vs_exp529.png?nolink |}}
</modal>

<modal id="8" size="lg" title="CR131-b 0.005μM R08 exp474  vs  GSK-J4 1.5μM R08 exp441">
{{:chemogenomics:comparison_plots:exp441_vs_exp474.png?nolink |}}
</modal>

<modal id="9" size="lg" title="CR131-b 0.005μM R08 exp474  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp474_vs_exp485.png?nolink |}}
</modal>

<modal id="10" size="lg" title="CR131-b 0.005μM R08 exp474  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp474.png?nolink |}}
</modal>

<modal id="11" size="lg" title="CR131-b 0.005μM R08 exp474  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp435_vs_exp474.png?nolink |}}
</modal>

<modal id="12" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp474_vs_exp503.png?nolink |}}
</modal>

<modal id="13" size="lg" title="CR131-b 0.005μM R08 exp474  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp474_vs_exp531.png?nolink |}}
</modal>

<modal id="14" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp474_vs_exp512.png?nolink |}}
</modal>

<modal id="15" size="lg" title="CR131-b 0.005μM R08 exp474  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp474.png?nolink |}}
</modal>

<modal id="16" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp357_vs_exp474.png?nolink |}}
</modal>

<modal id="17" size="lg" title="CR131-b 0.005μM R08 exp474  vs  TIC10 10μM R08 exp532">
{{:chemogenomics:comparison_plots:exp474_vs_exp532.png?nolink |}}
</modal>

<modal id="18" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp474_vs_exp527.png?nolink |}}
</modal>

<modal id="19" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp474.png?nolink |}}
</modal>

<modal id="20" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Hinokiflavone 12μM R08 exp487">
{{:chemogenomics:comparison_plots:exp474_vs_exp487.png?nolink |}}
</modal>

<modal id="21" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Latrunculin-B 10μM R07 exp374">
{{:chemogenomics:comparison_plots:exp374_vs_exp474.png?nolink |}}
</modal>

<modal id="22" size="lg" title="CR131-b 0.005μM R08 exp474  vs  ONC212 0.15μM R08 exp513">
{{:chemogenomics:comparison_plots:exp474_vs_exp513.png?nolink |}}
</modal>

<modal id="23" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp474.png?nolink |}}
</modal>

<modal id="24" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp474_vs_exp517.png?nolink |}}
</modal>

<modal id="25" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp474.png?nolink |}}
</modal>

<modal id="26" size="lg" title="CR131-b 0.005μM R08 exp474  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp474_vs_exp80.png?nolink |}}
</modal>

<modal id="27" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Rotenone 0.07μM R08 exp431">
{{:chemogenomics:comparison_plots:exp431_vs_exp474.png?nolink |}}
</modal>

<modal id="28" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp474.png?nolink |}}
</modal>

<modal id="29" size="lg" title="CR131-b 0.005μM R08 exp474  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp474_vs_exp492.png?nolink |}}
</modal>

<modal id="30" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Thapsigargin 0.005μM R07 exp407">
{{:chemogenomics:comparison_plots:exp407_vs_exp474.png?nolink |}}
</modal>

<modal id="31" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp436_vs_exp474.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Benzoate 20000μM R08 exp456  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp456_vs_exp474.png?nolink |}}
</modal>

<modal id="33" size="lg" title="AICAR 240μM R05 exp211  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp211_vs_exp474.png?nolink |}}
</modal>

<modal id="34" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp440_vs_exp474.png?nolink |}}
</modal>

<modal id="35" size="lg" title="Artemisinin 50μM R08 exp450  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp450_vs_exp474.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Bleomycin 5μM R08 exp459  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp459_vs_exp474.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Atovaquone 15μM R08 exp451  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp451_vs_exp474.png?nolink |}}
</modal>

<modal id="38" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  CR131-b 0.005μM R08 exp474">
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</modal>

<modal id="39" size="lg" title="CI-1040 9.5μM R08 exp472  vs  CR131-b 0.005μM R08 exp474">
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</modal>

<modal id="40" size="lg" title="AICAR 240μM R03 exp116  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp116_vs_exp474.png?nolink |}}
</modal>

<modal id="41" size="lg" title="5-Azacytidine 2μM R07 exp330  vs  CR131-b 0.005μM R08 exp474">
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</modal>

<modal id="42" size="lg" title="CB-5083 0.4μM R08 exp468  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp468_vs_exp474.png?nolink |}}
</modal>

<modal id="43" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  CR131-b 0.005μM R08 exp474">
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</modal>

<modal id="44" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp448_vs_exp474.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|regulation of G2/M transition of mitotic cell cycle|26.01|ZNF830,CDK2,AURKB,BRCA1|
|negative regulation of mitotic cell cycle phase transition|23.75|ZNF830,CDK2,AURKB,CDC73,BCL2,BRCA1|
|regulation of cell cycle G2/M phase transition|23.17|ZNF830,CDK2,AURKB,BRCA1|
|mitotic cell cycle checkpoint signaling|20.89|ZNF830,CDK2,AURKB,BRCA1|
|negative regulation of mitotic cell cycle|18.47|ZNF830,CDK2,AURKB,CDC73,BCL2,BRCA1|
|negative regulation of cell cycle phase transition|17.46|ZNF830,CDK2,AURKB,CDC73,BCL2,BRCA1|
|protein-RNA complex assembly|17.13|SNU13,DDX23,RPS28,CDC73,PSIP1|
|negative regulation of cell cycle process|17.03|ZNF830,CDK2,AURKB,CDC73,ESPL1,BCL2,BRCA1|
|protein-RNA complex organization|16.34|SNU13,DDX23,RPS28,CDC73,PSIP1|
|regulation of mitotic cell cycle phase transition|15.78|ZNF830,CDK2,AURKB,DDX3X,CDC73,ESPL1,BCL2,BRCA1|
|negative regulation of cell cycle|13.01|ZNF830,CDK2,AURKB,CDC73,ESPL1,BCL2,BRCA1|
|regulation of cell cycle phase transition|12.26|ZNF830,CDK2,AURKB,DDX3X,CDC73,ESPL1,BCL2,BRCA1|
|regulation of mitotic cell cycle|10.49|ZNF830,CDK2,AURKB,DDX3X,CDC73,ESPL1,BCL2,BRCA1|
|ribonucleoprotein complex biogenesis|10.40|NSUN5,SNU13,DDX23,RPS28,DDX3X,CDC73,PSIP1|
|mRNA processing|8.83|ZNF830,SNU13,DDX23,CDC73,PSIP1,SRSF3|
|regulation of cell cycle process|7.36|ZNF830,CDK2,AURKB,DDX3X,CDC73,ESPL1,BCL2,BRCA1|
|RNA processing|6.90|NSUN5,ZNF830,SNU13,DDX23,RPS28,DDX3X,CDC73,PSIP1,SRSF3|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.30|APAF1,CASP9|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|331.38|APAF1,CASP9,CYCS|
|Bcl-2 family protein complex|184.10|BAK1,PMAIP1,BCL2L11|
|thymocyte apoptotic process|165.69|BAK1,TP53,BCL2L11|
|positive regulation of release of cytochrome c from mitochondria|92.05|BAK1,PMAIP1,TP53,BCL2L11|
|positive regulation of mitochondrial membrane permeability|78.90|BAK1,VDAC2,TP53,BCL2L11|
|positive regulation of membrane permeability|71.26|BAK1,VDAC2,TP53,BCL2L11|
|regulation of mitochondrial membrane permeability|50.21|BAK1,VDAC2,PMAIP1,TP53,BCL2L11|
|regulation of release of cytochrome c from mitochondria|50.21|BAK1,PMAIP1,TP53,BCL2L11|
|apoptotic mitochondrial changes|49.31|BAK1,VDAC2,PMAIP1,TP53,BCL2L11|
|leukocyte apoptotic process|49.09|BAK1,CASP9,TP53,BCL2L11|
|regulation of membrane permeability|41.22|BAK1,VDAC2,PMAIP1,TP53,BCL2L11|
|positive regulation of mitochondrion organization|37.83|BAK1,MARCHF5,PMAIP1,TP53,BCL2L11|
|mitochondrial membrane organization|26.30|BAK1,VDAC2,PMAIP1,TP53,BCL2L11|
|intrinsic apoptotic signaling pathway|24.16|BAK1,APAF1,CASP9,CYCS,PMAIP1,TP53,BCL2L11|
|positive regulation of cysteine-type endopeptidase activity|22.45|BAK1,APAF1,CASP9,CYCS,PMAIP1|
|apoptotic signaling pathway|14.35|BAK1,APAF1,CASP9,CYCS,VDAC2,PMAIP1,TP53,BCL2L11|
|mitochondrial membrane|9.40|BAK1,HCCS,MARCHF5,ALAS1,CYCS,VDAC2,PMAIP1,COX7B,BCL2L11,FECH,MRPS5,TMEM126A|
|mitochondrial envelope|8.83|BAK1,HCCS,MARCHF5,ALAS1,CYCS,VDAC2,PMAIP1,COX7B,BCL2L11,FECH,MRPS5,TMEM126A|
</modal>