====== Mitomycin-C 0.06μM R08 exp503 ======
==== Mechanism of Action ====
DNA crosslinker, reductive activation forms a mitosene that N-alkylates successively DNA bases
  * **<color #00a2e8>Class / Subclass 1:</color>** DNA Damage, Repair and Replication / Inter/Intra-strand Crosslinker




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Mitomycin%%
    * **<color #00a2e8>Synonyms:</color>** Ametycine
    * **<color #00a2e8>CAS #:</color>** 50-07-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5746|5746]]
    * **<color #00a2e8>IUPAC:</color>** %%[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** NWIBSHFKIJFRCO-WUDYKRTCSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 334.33
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
    * **<color #00a2e8>Isomeric SMILES:</color>** CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
    * **<color #00a2e8>Molecular Formula:</color>** C15H18N4O5
{{:chemogenomics:structures:chem-0308.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** M371900
    * **<color #00a2e8>Lot #:</color>** 1-AWT-3-1
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C15H18N4O5 335.135; found 335.13842
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** MMC
    * **<color #00a2e8>Min:</color>** -9.1662; **<color #00a2e8>Max:</color>** 98.4658
{{:chemogenomics:dose_response:dr_558.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.0334    |
| IC20  |0.0482    |
| IC30  |0.0615    |
| IC40  |0.0751    |
| IC50  |0.0902    |
| IC60  |0.1083    |
| IC70  |0.1322    |
| IC80  |0.1687    |
| IC90  |0.2433    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 60nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.3
    * **<color #00a2e8>Numbers of reads</color>**: 16051073


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/56|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Mitomycin_C_0.06uM_Round-8_exp503.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Mitomycin-C 0.06μM R08 exp503'>
{{:chemogenomics:cranks_plots:exp503.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:H:HMGCR|HMGCR]]|-2.93|0.38|
|[[:human_genes:L:LARS|LARS]]|-2.65|0.62|
|[[:human_genes:M:MDM2|MDM2]]|-2.65|0.34|
|[[:human_genes:G:GPX4|GPX4]]|-2.44|0.34|
|[[:human_genes:T:TRIM16|TRIM16]]|-2.43|0.35|
|[[:human_genes:S:SLC17A5|SLC17A5]]|-2.41|0.34|
|[[:human_genes:E:EXOSC4|EXOSC4]]|-2.38|0.49|
|[[:human_genes:B:BRD2|BRD2]]|-2.34|0.38|
|[[:human_genes:C:CDK8|CDK8]]|-2.29|0.43|
|[[:human_genes:P:POLR2L|POLR2L]]|-2.26|0.64|
|[[:human_genes:R:RPS11|RPS11]]|-2.26|0.62|
|[[:human_genes:D:DDX47|DDX47]]|-2.22|0.62|
|[[:human_genes:V:VPS25|VPS25]]|-2.21|0.62|
|[[:human_genes:N:NFS1|NFS1]]|-2.18|0.63|
|[[:human_genes:N:NAT10|NAT10]]|-2.17|0.62|
|[[:human_genes:C:CHAF1A|CHAF1A]]|-2.15|0.62|
|[[:human_genes:P:POLR2J|POLR2J]]|-2.13|0.63|
|[[:human_genes:A:APOA4|APOA4]]|-2.12|0.62|
|[[:human_genes:H:HENMT1|HENMT1]]|-2.09|0.49|
|[[:human_genes:P:PSMA7|PSMA7]]|-2.09|0.62|
|[[:human_genes:A:ARCN1|ARCN1]]|-2.07|0.62|
|[[:human_genes:O:OTUB1|OTUB1]]|-2.02|0.62|
|[[:human_genes:A:ATG4D|ATG4D]]|-2.01|0.62|
|[[:human_genes:M:MAU2|MAU2]]|-1.99|0.63|
|[[:human_genes:M:MAP3K7|MAP3K7]]|-1.98|0.62|
|[[:human_genes:T:TBCC|TBCC]]|-1.97|0.66|
|[[:human_genes:R:REV1|REV1]]|-1.96|0.62|
|[[:human_genes:R:RPS17L|RPS17L]]|-1.96|0.63|
|[[:human_genes:E:ESPL1|ESPL1]]|-1.96|0.62|
|[[:human_genes:M:MGA|MGA]]|-1.96|0.62|
|[[:human_genes:T:THG1L|THG1L]]|2.79|<0.01|
|[[:human_genes:T:TRMT61A|TRMT61A]]|2.80|0.01|
|[[:human_genes:N:NSD1|NSD1]]|2.88|<0.01|
|[[:human_genes:A:ATP5O|ATP5O]]|2.93|<0.01|
|[[:human_genes:U:UBE2K|UBE2K]]|2.95|<0.01|
|[[:human_genes:R:ROMO1|ROMO1]]|3.01|<0.01|
|[[:human_genes:U:UHRF1|UHRF1]]|3.03|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|3.10|<0.01|
|[[:human_genes:P:PCBP2|PCBP2]]|3.11|0.00|
|[[:human_genes:M:MRPS33|MRPS33]]|3.12|<0.01|
|[[:human_genes:B:BAP1|BAP1]]|3.13|0.00|
|[[:human_genes:C:CEPT1|CEPT1]]|3.14|0.00|
|[[:human_genes:F:FBXO11|FBXO11]]|3.24|0.00|
|[[:human_genes:P:PML|PML]]|3.41|0.00|
|[[:human_genes:F:FAF2|FAF2]]|3.46|0.00|
|[[:human_genes:D:DOHH|DOHH]]|3.51|0.00|
|[[:human_genes:V:VDAC2|VDAC2]]|3.61|0.00|
|[[:human_genes:U:UBQLN1|UBQLN1]]|3.78|0.00|
|[[:human_genes:P:PLAA|PLAA]]|3.94|0.00|
|[[:human_genes:E:ENY2|ENY2]]|3.95|0.00|
|[[:human_genes:S:SLC52A2|SLC52A2]]|4.39|0.00|
|[[:human_genes:R:RMI1|RMI1]]|4.44|0.00|
|[[:human_genes:C:CASP9|CASP9]]|4.57|0.00|
|[[:human_genes:R:RMI2|RMI2]]|4.76|0.00|
|[[:human_genes:A:APAF1|APAF1]]|5.39|0.00|
|[[:human_genes:R:RFK|RFK]]|6.24|0.00|
|[[:human_genes:S:SLFN11|SLFN11]]|6.41|0.00|
|[[:human_genes:T:TP53|TP53]]|6.49|0.00|
|[[:human_genes:D:DUS1L|DUS1L]]|6.53|0.00|
|[[:human_genes:B:BAK1|BAK1]]|6.56|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.121|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.12|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.118|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.117|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.116|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.116|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.112|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp532|TIC10 10μM R08 exp532]]|0.11|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.107|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.105|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.09|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.071|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.064|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|0.063|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.063|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|0.054|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.051|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.156|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.15|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.14|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.139|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.135|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.127|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.127|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.125|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.123|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.106|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.098|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.096|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.096|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.095|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.095|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.092|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.087|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.086|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.083|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.078|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.078|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.078|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.072|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.072|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.069|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.067|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.064|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.063|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.061|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.06|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.06|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.058|<button type="primary" size="small" modal="49">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.057|<button type="primary" size="small" modal="50">View</button>|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|0.057|<button type="primary" size="small" modal="51">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.055|<button type="primary" size="small" modal="52">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.054|<button type="primary" size="small" modal="53">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.051|<button type="primary" size="small" modal="54">View</button>|
</modal>


<modal id="1" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp503_vs_exp512.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp503_vs_exp531.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp503_vs_exp515.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp503.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp503.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp503_vs_exp524.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp503_vs_exp527.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  TIC10 10μM R08 exp532">
{{:chemogenomics:comparison_plots:exp503_vs_exp532.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp503.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp503_vs_exp80.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp503.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp503_vs_exp529.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp503_vs_exp85.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  ONC212 0.15μM R08 exp513">
{{:chemogenomics:comparison_plots:exp503_vs_exp513.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp294_vs_exp503.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  QNZ 0.01μM R08 exp439">
{{:chemogenomics:comparison_plots:exp439_vs_exp503.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp503_vs_exp517.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Benzoate 20000μM R08 exp456  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp456_vs_exp503.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Bleomycin 5μM R08 exp459  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp459_vs_exp503.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp440_vs_exp503.png?nolink |}}
</modal>

<modal id="21" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp2_vs_exp503.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Atovaquone 15μM R08 exp451  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp451_vs_exp503.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp478_vs_exp503.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp199_vs_exp503.png?nolink |}}
</modal>

<modal id="25" size="lg" title="CI-1040 9.5μM R08 exp472  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp472_vs_exp503.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp3_vs_exp503.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp488_vs_exp503.png?nolink |}}
</modal>

<modal id="28" size="lg" title="AICAR 240μM R05 exp211  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp211_vs_exp503.png?nolink |}}
</modal>

<modal id="29" size="lg" title="JQ1 0.8μM R08 exp435  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp435_vs_exp503.png?nolink |}}
</modal>

<modal id="30" size="lg" title="GSK-J4 1.5μM R08 exp441  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp441_vs_exp503.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Etoposide 1μM R00 exp19  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp19_vs_exp503.png?nolink |}}
</modal>

<modal id="32" size="lg" title="MS023 7μM R03 exp135  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp135_vs_exp503.png?nolink |}}
</modal>

<modal id="33" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp489_vs_exp503.png?nolink |}}
</modal>

<modal id="34" size="lg" title="GSK626616 14μM R08 exp485  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp485_vs_exp503.png?nolink |}}
</modal>

<modal id="35" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp259_vs_exp503.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp357_vs_exp503.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Artemisinin 50μM R08 exp450  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp450_vs_exp503.png?nolink |}}
</modal>

<modal id="38" size="lg" title="BI-2536 0.02μM R03 exp96  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp503_vs_exp96.png?nolink |}}
</modal>

<modal id="39" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp474_vs_exp503.png?nolink |}}
</modal>

<modal id="40" size="lg" title="Diepoxybutane 3μM R07 exp354  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp354_vs_exp503.png?nolink |}}
</modal>

<modal id="41" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp355_vs_exp503.png?nolink |}}
</modal>

<modal id="42" size="lg" title="AICAR 240μM R03 exp116  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp116_vs_exp503.png?nolink |}}
</modal>

<modal id="43" size="lg" title="BI-6727 0.04μM R03 exp98  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp503_vs_exp98.png?nolink |}}
</modal>

<modal id="44" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp350_vs_exp503.png?nolink |}}
</modal>

<modal id="45" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp448_vs_exp503.png?nolink |}}
</modal>

<modal id="46" size="lg" title="MLN-4924 2μM R00 exp22  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp22_vs_exp503.png?nolink |}}
</modal>

<modal id="47" size="lg" title="42°C R08 exp539  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp503_vs_exp539.png?nolink |}}
</modal>

<modal id="48" size="lg" title="MS023 2μM R03 exp134  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp134_vs_exp503.png?nolink |}}
</modal>

<modal id="49" size="lg" title="Centrinone 0.5μM R07 exp343  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp343_vs_exp503.png?nolink |}}
</modal>

<modal id="50" size="lg" title="GSK461364A 0.1μM R03 exp126  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp126_vs_exp503.png?nolink |}}
</modal>

<modal id="51" size="lg" title="DABN racemic mixture R03 exp93  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp503_vs_exp93.png?nolink |}}
</modal>

<modal id="52" size="lg" title="Milciclib 2μM R08 exp502  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp502_vs_exp503.png?nolink |}}
</modal>

<modal id="53" size="lg" title="Latrunculin-B 10μM R07 exp374  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp374_vs_exp503.png?nolink |}}
</modal>

<modal id="54" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp329_vs_exp503.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.30|APAF1,CASP9|
|RecQ family helicase-topoisomerase III complex|368.20|RMI2,RMI1|
|glial cell apoptotic process|276.15|TP53,CASP9|
|flavin-containing compound metabolic process|220.92|RFK,SLC52A2|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|66.95|BAK1,TP53,APAF1,PML|
|positive regulation of mitochondrial membrane permeability|59.18|BAK1,TP53,VDAC2|
|positive regulation of membrane permeability|53.45|BAK1,TP53,VDAC2|
|intrinsic apoptotic signaling pathway in response to DNA damage|31.12|BAK1,TP53,CASP9,PML|
|intrinsic apoptotic signaling pathway|17.26|BAK1,TP53,APAF1,CASP9,PML|
|response to endoplasmic reticulum stress|14.73|BAK1,TP53,APAF1,UBQLN1,FAF2,PML|
|apoptotic signaling pathway|10.76|BAK1,TP53,APAF1,CASP9,VDAC2,PML|
|ubiquitin-dependent protein catabolic process|9.73|PLAA,UBQLN1,FAF2,PML,FBXO11,BAP1,PCBP2,UHRF1,UBE2K|
|proteasome-mediated ubiquitin-dependent protein catabolic process|9.61|PLAA,UBQLN1,FAF2,PML,PCBP2,UBE2K|
|modification-dependent protein catabolic process|9.54|PLAA,UBQLN1,FAF2,PML,FBXO11,BAP1,PCBP2,UHRF1,UBE2K|
|modification-dependent macromolecule catabolic process|9.34|PLAA,UBQLN1,FAF2,PML,FBXO11,BAP1,PCBP2,UHRF1,UBE2K|
|proteolysis involved in protein catabolic process|8.53|PLAA,UBQLN1,FAF2,PML,FBXO11,BAP1,PCBP2,UHRF1,UBE2K|
|protein catabolic process|7.15|PLAA,UBQLN1,FAF2,PML,FBXO11,BAP1,PCBP2,UHRF1,UBE2K|
|DNA damage response|6.21|BAK1,TP53,SLFN11,RMI2,CASP9,RMI1,PML,UHRF1|
|macromolecule catabolic process|5.39|PLAA,UBQLN1,FAF2,PML,FBXO11,BAP1,PCBP2,UHRF1,UBE2K|
</modal>