====== RS-1 10μM R08 exp519 ======
==== Mechanism of Action ====
Activates DNA binding by RAD51
  * **<color #00a2e8>Class / Subclass 1:</color>** DNA Damage, Repair and Replication / Repair Protein Activator




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%3-(Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 312756-74-4
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/1039737|1039737]]
    * **<color #00a2e8>IUPAC:</color>** %%3-(benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
    * **<color #00a2e8>INCHI Key:</color>** SWKAVEUTKGKHSR-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 524.2
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C(C=C1)CNS(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC=C(C=C3)Br)Br
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C20H16Br2N2O3S
{{:chemogenomics:structures:chem-0324.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Cayman Chemical
    * **<color #00a2e8>Catalog #:</color>** 21037
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H16Br2N2O3S 522.93212; found 522.93209
</panel>


<panel title='Dose Response Curve'>
Dose response curve not available.
</panel>


</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 10µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.6
    * **<color #00a2e8>Numbers of reads</color>**: 16262228


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/RS-1_10uM_Round-8_exp519.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='RS-1 10μM R08 exp519'>
{{:chemogenomics:cranks_plots:exp519.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:G:GOT1|GOT1]]|-2.68|0.08|
|[[:human_genes:A:AASDHPPT|AASDHPPT]]|-2.61|0.08|
|[[:human_genes:C:CSK|CSK]]|-2.58|0.08|
|[[:human_genes:L:LRIG2|LRIG2]]|-2.51|0.08|
|[[:human_genes:S:SLC38A5|SLC38A5]]|-2.48|0.08|
|[[:human_genes:S:STYX|STYX]]|-2.42|0.20|
|[[:human_genes:B:BCORL1|BCORL1]]|-2.36|0.20|
|[[:human_genes:Z:ZFAND3|ZFAND3]]|-2.34|0.16|
|[[:human_genes:U:UROD|UROD]]|-2.29|0.43|
|[[:human_genes:S:STARD8|STARD8]]|-2.25|0.20|
|[[:human_genes:G:GMPPB|GMPPB]]|-2.23|0.72|
|[[:human_genes:G:GPATCH1|GPATCH1]]|-2.22|0.20|
|[[:human_genes:S:SCAP|SCAP]]|-2.19|0.21|
|[[:human_genes:U:UGT1A9|UGT1A9]]|-2.16|0.23|
|[[:human_genes:G:GOLGA8H|GOLGA8H]]|-2.14|0.74|
|[[:human_genes:L:LMAN2|LMAN2]]|-2.13|0.25|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.12|0.25|
|[[:human_genes:S:SAYSD1|SAYSD1]]|-2.10|0.26|
|[[:human_genes:H:HABP2|HABP2]]|-2.09|0.36|
|[[:human_genes:C:C6orf136|C6orf136]]|-2.09|0.36|
|[[:human_genes:U:UBA3|UBA3]]|-2.08|0.50|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-2.05|0.33|
|[[:human_genes:O:OR2T27|OR2T27]]|-2.04|0.33|
|[[:human_genes:S:SCD|SCD]]|-2.03|0.41|
|[[:human_genes:C:CHAF1A|CHAF1A]]|-2.03|0.72|
|[[:human_genes:C:C20orf24|C20orf24]]|-1.99|0.36|
|[[:human_genes:M:MYPN|MYPN]]|-1.97|0.36|
|[[:human_genes:M:MLYCD|MLYCD]]|-1.97|0.36|
|[[:human_genes:H:HHLA2|HHLA2]]|-1.96|0.36|
|[[:human_genes:C:C16orf46|C16orf46]]|-1.95|0.65|
|[[:human_genes:S:SLC25A3|SLC25A3]]|1.91|0.54|
|[[:human_genes:H:HNRNPAB|HNRNPAB]]|1.91|0.54|
|[[:human_genes:E:EIF1|EIF1]]|1.91|0.70|
|[[:human_genes:C:CIDEB|CIDEB]]|1.92|0.54|
|[[:human_genes:A:ATXN1|ATXN1]]|1.92|0.70|
|[[:human_genes:N:NFYA|NFYA]]|1.92|0.70|
|[[:human_genes:N:NDC80|NDC80]]|1.93|0.75|
|[[:human_genes:C:COX4I2|COX4I2]]|1.93|0.54|
|[[:human_genes:P:PRPS1|PRPS1]]|1.94|0.54|
|[[:human_genes:K:KIF3B|KIF3B]]|1.96|0.70|
|[[:human_genes:S:SERGEF|SERGEF]]|1.97|0.54|
|[[:human_genes:G:GLRX3|GLRX3]]|1.98|0.54|
|[[:human_genes:P:PBX1|PBX1]]|2.01|0.54|
|[[:human_genes:I:INTS2|INTS2]]|2.04|0.54|
|[[:human_genes:P:PAFAH1B1|PAFAH1B1]]|2.05|0.76|
|[[:human_genes:P:PRKD3|PRKD3]]|2.05|0.50|
|[[:human_genes:C:CEP192|CEP192]]|2.07|0.60|
|[[:human_genes:L:LACTB|LACTB]]|2.08|0.46|
|[[:human_genes:B:BCL2A1|BCL2A1]]|2.10|0.46|
|[[:human_genes:M:MANSC4|MANSC4]]|2.12|0.45|
|[[:human_genes:A:ACBD3|ACBD3]]|2.16|0.54|
|[[:human_genes:E:ESAM|ESAM]]|2.18|0.36|
|[[:human_genes:F:FAM129B|FAM129B]]|2.20|0.54|
|[[:human_genes:R:RACGAP1|RACGAP1]]|2.23|0.54|
|[[:human_genes:H:HAT1|HAT1]]|2.30|0.32|
|[[:human_genes:D:DPH1|DPH1]]|2.33|0.32|
|[[:human_genes:P:PSME3|PSME3]]|2.33|0.36|
|[[:human_genes:U:UTP3|UTP3]]|2.35|0.36|
|[[:human_genes:L:LIPT1|LIPT1]]|2.44|0.28|
|[[:human_genes:S:SLC25A19|SLC25A19]]|2.64|0.17|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>