====== THZ1 0.06μM R08 exp531 ======
==== Mechanism of Action ====
Inhibits CDK7, forms covalent adduct, blocks phosphorylation of the C-terminal domain of RNA polymerase II
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Transcription Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / Kinase Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%THZ1 Hydrochloride%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/78358326|78358326]]
    * **<color #00a2e8>IUPAC:</color>** %%N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide;hydrochloride%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C31H28ClN7O2.ClH/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27;/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38);1H/b11-6+;
    * **<color #00a2e8>INCHI Key:</color>** LSAGMHUBJCPLJS-ICSBZGNSSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 602.5
    * **<color #00a2e8>Canonical SMILES:</color>** CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl.Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl.Cl
    * **<color #00a2e8>Molecular Formula:</color>** C31H29Cl2N7O2
{{:chemogenomics:structures:chem-0335.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-80013A
    * **<color #00a2e8>Lot #:</color>** 25842
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C31H28ClN7O2 566.20658; found 566.20799
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** THZ1
    * **<color #00a2e8>Min:</color>** -3.2339; **<color #00a2e8>Max:</color>** 99.8907
{{:chemogenomics:dose_response:dr_588.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.0053    |
| IC20  |0.0131    |
| IC30  |0.0240    |
| IC40  |0.0394    |
| IC50  |0.0622    |
| IC60  |0.0981    |
| IC70  |0.1612    |
| IC80  |0.2954    |
| IC90  |0.7349    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 60nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: -0.3
    * **<color #00a2e8>Numbers of reads</color>**: 16956922


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/42|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/THZ1_0.06uM_Round-8_exp531.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='THZ1 0.06μM R08 exp531'>
{{:chemogenomics:cranks_plots:exp531.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:W:WDR61|WDR61]]|-2.73|0.28|
|[[:human_genes:P:POLD2|POLD2]]|-2.69|0.28|
|[[:human_genes:F:FANCI|FANCI]]|-2.63|0.28|
|[[:human_genes:G:GOLGA6L1|GOLGA6L1]]|-2.56|0.53|
|[[:human_genes:N:NCLN|NCLN]]|-2.54|0.28|
|[[:human_genes:P:PSMA1|PSMA1]]|-2.45|0.29|
|[[:human_genes:E:EXOSC4|EXOSC4]]|-2.40|0.29|
|[[:human_genes:A:ATP6V1A|ATP6V1A]]|-2.34|0.29|
|[[:human_genes:U:UBA1|UBA1]]|-2.34|0.52|
|[[:human_genes:S:SPI1|SPI1]]|-2.34|0.28|
|[[:human_genes:R:RPS9|RPS9]]|-2.28|0.53|
|[[:human_genes:H:HIST1H4E|HIST1H4E]]|-2.26|0.28|
|[[:human_genes:T:TAF9|TAF9]]|-2.24|0.28|
|[[:human_genes:A:ABCA13|ABCA13]]|-2.23|0.29|
|[[:human_genes:F:FAM186A|FAM186A]]|-2.21|0.29|
|[[:human_genes:C:CFLAR|CFLAR]]|-2.20|0.28|
|[[:human_genes:C:CMC2|CMC2]]|-2.18|0.51|
|[[:human_genes:C:CDC73|CDC73]]|-2.17|0.36|
|[[:human_genes:Z:ZNF121|ZNF121]]|-2.17|0.28|
|[[:human_genes:C:CHD8|CHD8]]|-2.16|0.28|
|[[:human_genes:B:BCOR|BCOR]]|-2.15|0.28|
|[[:human_genes:F:FADS6|FADS6]]|-2.14|0.39|
|[[:human_genes:C:CDCA8|CDCA8]]|-2.14|0.51|
|[[:human_genes:T:TRIM36|TRIM36]]|-2.12|0.29|
|[[:human_genes:T:TAS2R60|TAS2R60]]|-2.09|0.29|
|[[:human_genes:U:UBXN1|UBXN1]]|-2.08|0.41|
|[[:human_genes:P:PASD1|PASD1]]|-2.08|0.29|
|[[:human_genes:F:FPR2|FPR2]]|-2.06|0.36|
|[[:human_genes:S:SART1|SART1]]|-2.06|0.53|
|[[:human_genes:I:IL12A|IL12A]]|-2.06|0.29|
|[[:human_genes:A:ATP5B|ATP5B]]|2.51|0.01|
|[[:human_genes:T:TAZ|TAZ]]|2.51|0.15|
|[[:human_genes:C:CDH22|CDH22]]|2.52|0.02|
|[[:human_genes:P:PARL|PARL]]|2.56|0.02|
|[[:human_genes:T:THG1L|THG1L]]|2.60|0.01|
|[[:human_genes:D:DOHH|DOHH]]|2.60|0.02|
|[[:human_genes:M:MARCH5|MARCH5]]|2.60|0.02|
|[[:human_genes:C:C10orf12|C10orf12]]|2.64|0.02|
|[[:human_genes:M:MLST8|MLST8]]|2.70|<0.01|
|[[:human_genes:T:TTI2|TTI2]]|2.73|0.01|
|[[:human_genes:H:HSPD1|HSPD1]]|2.74|<0.01|
|[[:human_genes:T:TP53|TP53]]|2.84|<0.01|
|[[:human_genes:T:TTI1|TTI1]]|2.84|<0.01|
|[[:human_genes:G:GNB1L|GNB1L]]|2.87|<0.01|
|[[:human_genes:F:FBXO11|FBXO11]]|2.88|<0.01|
|[[:human_genes:M:MED23|MED23]]|2.88|<0.01|
|[[:human_genes:C:CASP9|CASP9]]|2.97|<0.01|
|[[:human_genes:V:VDAC2|VDAC2]]|3.13|<0.01|
|[[:human_genes:A:ALAS1|ALAS1]]|3.13|0.01|
|[[:human_genes:M:MTOR|MTOR]]|3.15|<0.01|
|[[:human_genes:K:KMT2D|KMT2D]]|3.16|<0.01|
|[[:human_genes:R:RPTOR|RPTOR]]|3.17|<0.01|
|[[:human_genes:T:TELO2|TELO2]]|3.26|<0.01|
|[[:human_genes:C:CYCS|CYCS]]|3.41|<0.01|
|[[:human_genes:A:ATP5J|ATP5J]]|3.53|<0.01|
|[[:human_genes:H:HCCS|HCCS]]|3.94|<0.01|
|[[:human_genes:A:APAF1|APAF1]]|4.18|<0.01|
|[[:human_genes:G:GMPPB|GMPPB]]|4.74|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|5.68|<0.01|
|[[:human_genes:B:BEND3|BEND3]]|7.22|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.089|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp532|TIC10 10μM R08 exp532]]|0.06|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.053|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.052|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.146|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.146|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.142|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.136|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.128|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.124|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.12|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.112|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.106|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.103|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.099|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.096|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.096|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.095|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.094|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.093|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.093|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.093|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.091|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.09|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.089|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.086|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.081|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.078|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.077|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.077|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|0.075|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp17|DABN 20μM R00 exp17]]|0.074|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.074|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.064|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.062|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.062|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.062|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.061|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.059|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.057|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.057|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.055|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|0.053|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.052|<button type="primary" size="small" modal="44">View</button>|
</modal>


<modal id="1" size="lg" title="THZ1 0.06μM R08 exp531  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp527_vs_exp531.png?nolink |}}
</modal>

<modal id="2" size="lg" title="THZ1 0.06μM R08 exp531  vs  TIC10 10μM R08 exp532">
{{:chemogenomics:comparison_plots:exp531_vs_exp532.png?nolink |}}
</modal>

<modal id="3" size="lg" title="THZ1 0.06μM R08 exp531  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp531.png?nolink |}}
</modal>

<modal id="4" size="lg" title="THZ1 0.06μM R08 exp531  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp529_vs_exp531.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp478_vs_exp531.png?nolink |}}
</modal>

<modal id="6" size="lg" title="SNS-032 15μM R08 exp443  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp443_vs_exp531.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Bleomycin 5μM R08 exp459  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp459_vs_exp531.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Benzoate 20000μM R08 exp456  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp456_vs_exp531.png?nolink |}}
</modal>

<modal id="9" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp2_vs_exp531.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp28_vs_exp531.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp503_vs_exp531.png?nolink |}}
</modal>

<modal id="12" size="lg" title="CI-1040 9.5μM R08 exp472  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp472_vs_exp531.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp3_vs_exp531.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Etoposide 0.3μM R05 exp199  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp199_vs_exp531.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Atovaquone 15μM R08 exp451  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp451_vs_exp531.png?nolink |}}
</modal>

<modal id="16" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp259_vs_exp531.png?nolink |}}
</modal>

<modal id="17" size="lg" title="MLN-4924 2μM R00 exp22  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp22_vs_exp531.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp440_vs_exp531.png?nolink |}}
</modal>

<modal id="19" size="lg" title="MS023 7μM R03 exp135  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp135_vs_exp531.png?nolink |}}
</modal>

<modal id="20" size="lg" title="RO-3307 4.7μM R02 exp80  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp531_vs_exp80.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Rotenone 20μM R00 exp34  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp34_vs_exp531.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp488_vs_exp531.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp489_vs_exp531.png?nolink |}}
</modal>

<modal id="24" size="lg" title="AICAR 240μM R05 exp211  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp211_vs_exp531.png?nolink |}}
</modal>

<modal id="25" size="lg" title="PU-H71 1μM R08 exp515  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp515_vs_exp531.png?nolink |}}
</modal>

<modal id="26" size="lg" title="JQ1 0.8μM R08 exp435  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp435_vs_exp531.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Etoposide 1μM R00 exp19  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp19_vs_exp531.png?nolink |}}
</modal>

<modal id="28" size="lg" title="BI-2536 0.02μM R03 exp96  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp531_vs_exp96.png?nolink |}}
</modal>

<modal id="29" size="lg" title="CR131-b 0.005μM R08 exp474  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp474_vs_exp531.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Staurosporine 0.02μM R08 exp524  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp524_vs_exp531.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Hinokiflavone 12μM R08 exp487  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp487_vs_exp531.png?nolink |}}
</modal>

<modal id="32" size="lg" title="DABN 20μM R00 exp17  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp17_vs_exp531.png?nolink |}}
</modal>

<modal id="33" size="lg" title="Olaparib 4μM R08 exp512  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp512_vs_exp531.png?nolink |}}
</modal>

<modal id="34" size="lg" title="MS023 2μM R03 exp134  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp134_vs_exp531.png?nolink |}}
</modal>

<modal id="35" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp448_vs_exp531.png?nolink |}}
</modal>

<modal id="36" size="lg" title="GSK461364A 0.1μM R03 exp126  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp126_vs_exp531.png?nolink |}}
</modal>

<modal id="37" size="lg" title="BI-6727 0.04μM R03 exp98  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp531_vs_exp98.png?nolink |}}
</modal>

<modal id="38" size="lg" title="GSK626616 14μM R08 exp485  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp485_vs_exp531.png?nolink |}}
</modal>

<modal id="39" size="lg" title="42°C R08 exp539  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp531_vs_exp539.png?nolink |}}
</modal>

<modal id="40" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp500_vs_exp531.png?nolink |}}
</modal>

<modal id="41" size="lg" title="GSK-J4 1.5μM R08 exp441  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp441_vs_exp531.png?nolink |}}
</modal>

<modal id="42" size="lg" title="Quercetin 20μM R08 exp517  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp517_vs_exp531.png?nolink |}}
</modal>

<modal id="43" size="lg" title="DABN racemic mixture R03 exp93  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp531_vs_exp93.png?nolink |}}
</modal>

<modal id="44" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp357_vs_exp531.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.30|APAF1,CASP9|
|positive regulation of pentose-phosphate shunt|552.30|RPTOR,MLST8|
|TTT complex|552.30|TELO2,TTI1|
|TORC1 complex|441.84|TELO2,MTOR,TTI1,MLST8|
|regulation of pentose-phosphate shunt|368.20|RPTOR,MTOR,TP53,MLST8|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|331.38|APAF1,CYCS,CASP9|
|regulation of NADP metabolic process|315.60|RPTOR,MTOR,TP53,MLST8|
|TOR complex|276.15|TELO2,RPTOR,MTOR,TTI1,MLST8|
|TORC2 complex|276.15|TELO2,MTOR,TTI1,MLST8|
|rDNA binding|165.69|BEND3,RPTOR,MTOR|
|TORC1 signaling|150.63|RPTOR,MTOR,MLST8|
|positive regulation of purine nucleotide metabolic process|129.95|BEND3,RPTOR,MTOR,MLST8|
|positive regulation of nucleotide metabolic process|129.95|BEND3,RPTOR,MTOR,MLST8|
|regulation of purine nucleotide metabolic process|65.75|BEND3,RPTOR,MTOR,TP53,MLST8|
|regulation of nucleotide metabolic process|64.22|BEND3,RPTOR,MTOR,TP53,MLST8|
|apoptotic mitochondrial changes|39.45|BAK1,VDAC2,TP53,HSPD1|
|positive regulation of cysteine-type endopeptidase activity|22.45|BAK1,APAF1,CYCS,CASP9,HSPD1|
|mitochondrial membrane|9.40|BAK1,HCCS,ATP5PF,CYCS,MTOR,ALAS1,VDAC2,HSPD1,MARCHF5,THG1L,PARL,ATP5F1B|
|mitochondrial envelope|8.83|BAK1,HCCS,ATP5PF,CYCS,MTOR,ALAS1,VDAC2,HSPD1,MARCHF5,THG1L,PARL,ATP5F1B|
</modal>