====== 42°C R08 exp539 ======
==== Mechanism of Action ====
Elevated growth temperature
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Stress Condition




==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: N/A
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: -0.5
    * **<color #00a2e8>Numbers of reads</color>**: 18691098


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/26|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/42oC_Round-8_exp539.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='42°C R08 exp539'>
{{:chemogenomics:cranks_plots:exp539.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:V:VPS52|VPS52]]|-3.30|0.07|
|[[:human_genes:V:VPS25|VPS25]]|-2.90|0.19|
|[[:human_genes:L:LMNB1|LMNB1]]|-2.85|0.05|
|[[:human_genes:B:BRD2|BRD2]]|-2.76|0.06|
|[[:human_genes:N:NAPA|NAPA]]|-2.70|0.17|
|[[:human_genes:M:MPHOSPH8|MPHOSPH8]]|-2.62|0.06|
|[[:human_genes:C:CTNNBL1|CTNNBL1]]|-2.59|0.06|
|[[:human_genes:U:USP8|USP8]]|-2.51|0.12|
|[[:human_genes:U:UBXN4|UBXN4]]|-2.51|0.07|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.49|0.10|
|[[:human_genes:C:COG1|COG1]]|-2.47|0.07|
|[[:human_genes:D:DDX23|DDX23]]|-2.44|0.36|
|[[:human_genes:M:MAEA|MAEA]]|-2.43|0.07|
|[[:human_genes:C:CDC20|CDC20]]|-2.40|0.19|
|[[:human_genes:P:PRPF19|PRPF19]]|-2.38|0.20|
|[[:human_genes:I:ILF3|ILF3]]|-2.38|0.27|
|[[:human_genes:C:CHMP2A|CHMP2A]]|-2.37|0.20|
|[[:human_genes:T:TSSC1|TSSC1]]|-2.36|0.10|
|[[:human_genes:S:SF3A1|SF3A1]]|-2.35|0.20|
|[[:human_genes:H:HTATSF1|HTATSF1]]|-2.34|0.17|
|[[:human_genes:C:CLN3|CLN3]]|-2.32|0.12|
|[[:human_genes:R:RCN1|RCN1]]|-2.31|0.11|
|[[:human_genes:R:RINT1|RINT1]]|-2.31|0.17|
|[[:human_genes:K:KMT2E|KMT2E]]|-2.30|0.11|
|[[:human_genes:R:RRM2|RRM2]]|-2.27|0.52|
|[[:human_genes:C:COG3|COG3]]|-2.26|0.11|
|[[:human_genes:B:BROX|BROX]]|-2.26|0.11|
|[[:human_genes:T:TRAPPC13|TRAPPC13]]|-2.25|0.11|
|[[:human_genes:T:TRAPPC2L|TRAPPC2L]]|-2.25|0.11|
|[[:human_genes:A:ACYP2|ACYP2]]|-2.21|0.16|
|[[:human_genes:A:ATP5A1|ATP5A1]]|2.36|0.09|
|[[:human_genes:C:CRLS1|CRLS1]]|2.37|0.04|
|[[:human_genes:O:OTUD5|OTUD5]]|2.37|0.09|
|[[:human_genes:H:HSP90AA1|HSP90AA1]]|2.38|0.04|
|[[:human_genes:H:HCCS|HCCS]]|2.38|0.09|
|[[:human_genes:A:AHSA1|AHSA1]]|2.39|0.04|
|[[:human_genes:A:ATG10|ATG10]]|2.41|0.04|
|[[:human_genes:U:UBR4|UBR4]]|2.44|0.08|
|[[:human_genes:N:N6AMT1|N6AMT1]]|2.52|0.09|
|[[:human_genes:O:OPA1|OPA1]]|2.52|0.04|
|[[:human_genes:R:RPTOR|RPTOR]]|2.57|0.04|
|[[:human_genes:T:TRIAP1|TRIAP1]]|2.62|0.04|
|[[:human_genes:C:COX15|COX15]]|2.65|0.01|
|[[:human_genes:T:TAZ|TAZ]]|2.66|0.12|
|[[:human_genes:N:NDUFAF4|NDUFAF4]]|2.69|<0.01|
|[[:human_genes:P:PGGT1B|PGGT1B]]|2.70|<0.01|
|[[:human_genes:P:PELO|PELO]]|2.72|0.04|
|[[:human_genes:P:PMM2|PMM2]]|2.73|<0.01|
|[[:human_genes:H:HSP90B1|HSP90B1]]|2.85|<0.01|
|[[:human_genes:D:DERL2|DERL2]]|2.95|<0.01|
|[[:human_genes:S:SUPV3L1|SUPV3L1]]|2.98|0.01|
|[[:human_genes:A:ALG5|ALG5]]|3.06|<0.01|
|[[:human_genes:S:STT3A|STT3A]]|3.12|0.02|
|[[:human_genes:C:CCDC101|CCDC101]]|3.22|<0.01|
|[[:human_genes:T:TMED10|TMED10]]|3.40|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|3.44|<0.01|
|[[:human_genes:M:MBTPS2|MBTPS2]]|3.51|<0.01|
|[[:human_genes:K:KCMF1|KCMF1]]|3.57|<0.01|
|[[:human_genes:H:HTRA2|HTRA2]]|4.36|<0.01|
|[[:human_genes:G:GMPPB|GMPPB]]|4.36|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.11|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.099|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.091|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.09|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.078|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.077|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.077|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.073|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.07|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.069|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.067|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.065|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.065|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.063|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.062|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.062|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.062|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.061|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.061|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.06|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.059|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|0.059|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.057|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.056|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|0.056|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.055|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.054|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.053|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.052|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.052|<button type="primary" size="small" modal="30">View</button>|
</modal>


<modal id="1" size="lg" title="42°C R08 exp539  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp515_vs_exp539.png?nolink |}}
</modal>

<modal id="2" size="lg" title="42°C R08 exp539  vs  CI-1040 9.5μM R08 exp472">
{{:chemogenomics:comparison_plots:exp472_vs_exp539.png?nolink |}}
</modal>

<modal id="3" size="lg" title="42°C R08 exp539  vs  5-Fluorouracil 20μM R00 exp2">
{{:chemogenomics:comparison_plots:exp2_vs_exp539.png?nolink |}}
</modal>

<modal id="4" size="lg" title="42°C R08 exp539  vs  GSK461364A 0.1μM R03 exp126">
{{:chemogenomics:comparison_plots:exp126_vs_exp539.png?nolink |}}
</modal>

<modal id="5" size="lg" title="42°C R08 exp539  vs  Ammonium tetrathiomolybdate 10μM R08 exp448">
{{:chemogenomics:comparison_plots:exp448_vs_exp539.png?nolink |}}
</modal>

<modal id="6" size="lg" title="42°C R08 exp539  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp539.png?nolink |}}
</modal>

<modal id="7" size="lg" title="42°C R08 exp539  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp539.png?nolink |}}
</modal>

<modal id="8" size="lg" title="42°C R08 exp539  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp478_vs_exp539.png?nolink |}}
</modal>

<modal id="9" size="lg" title="42°C R08 exp539  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp488_vs_exp539.png?nolink |}}
</modal>

<modal id="10" size="lg" title="42°C R08 exp539  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp3_vs_exp539.png?nolink |}}
</modal>

<modal id="11" size="lg" title="42°C R08 exp539  vs  Bleomycin 5μM R08 exp459">
{{:chemogenomics:comparison_plots:exp459_vs_exp539.png?nolink |}}
</modal>

<modal id="12" size="lg" title="42°C R08 exp539  vs  Vinblastine 0.2μM R03 exp108">
{{:chemogenomics:comparison_plots:exp108_vs_exp539.png?nolink |}}
</modal>

<modal id="13" size="lg" title="42°C R08 exp539  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp527_vs_exp539.png?nolink |}}
</modal>

<modal id="14" size="lg" title="42°C R08 exp539  vs  Atovaquone 15μM R08 exp451">
{{:chemogenomics:comparison_plots:exp451_vs_exp539.png?nolink |}}
</modal>

<modal id="15" size="lg" title="42°C R08 exp539  vs  Benzoate 20000μM R08 exp456">
{{:chemogenomics:comparison_plots:exp456_vs_exp539.png?nolink |}}
</modal>

<modal id="16" size="lg" title="42°C R08 exp539  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp440_vs_exp539.png?nolink |}}
</modal>

<modal id="17" size="lg" title="42°C R08 exp539  vs  MLN-4924 2μM R00 exp22">
{{:chemogenomics:comparison_plots:exp22_vs_exp539.png?nolink |}}
</modal>

<modal id="18" size="lg" title="42°C R08 exp539  vs  BI-2536 0.02μM R03 exp96">
{{:chemogenomics:comparison_plots:exp539_vs_exp96.png?nolink |}}
</modal>

<modal id="19" size="lg" title="42°C R08 exp539  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp539.png?nolink |}}
</modal>

<modal id="20" size="lg" title="42°C R08 exp539  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp503_vs_exp539.png?nolink |}}
</modal>

<modal id="21" size="lg" title="42°C R08 exp539  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp531_vs_exp539.png?nolink |}}
</modal>

<modal id="22" size="lg" title="42°C R08 exp539  vs  Hinokiflavone 12μM R08 exp487">
{{:chemogenomics:comparison_plots:exp487_vs_exp539.png?nolink |}}
</modal>

<modal id="23" size="lg" title="42°C R08 exp539  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp489_vs_exp539.png?nolink |}}
</modal>

<modal id="24" size="lg" title="42°C R08 exp539  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp529_vs_exp539.png?nolink |}}
</modal>

<modal id="25" size="lg" title="42°C R08 exp539  vs  CFI-400945 25μM R08 exp469">
{{:chemogenomics:comparison_plots:exp469_vs_exp539.png?nolink |}}
</modal>

<modal id="26" size="lg" title="42°C R08 exp539  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp539.png?nolink |}}
</modal>

<modal id="27" size="lg" title="42°C R08 exp539  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp539.png?nolink |}}
</modal>

<modal id="28" size="lg" title="42°C R08 exp539  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp435_vs_exp539.png?nolink |}}
</modal>

<modal id="29" size="lg" title="42°C R08 exp539  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp539.png?nolink |}}
</modal>

<modal id="30" size="lg" title="42°C R08 exp539  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp539.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|vesicle tethering complex|63.48|VPS52,COG1,RINT1,COG3,TRAPPC13,TRAPPC2L|
|spliceosomal complex assembly|32.65|DDX23,PRPF19,SF3A1,HTATSF1|
|Golgi vesicle transport|16.62|VPS52,NAPA,COG1,CLN3,RINT1,COG3,TRAPPC13,TRAPPC2L|
|endomembrane system organization|8.66|VPS25,LMNB1,USP8,COG1,CHMP2A,CLN3,COG3,BROX|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|mitochondrial envelope|7.35|HTRA2,BAK1,NDUFAF4,COX15,TRIAP1,OPA1,HCCS,CRLS1,ATP5F1A,TAMM41|
|mitochondrial membrane|7.05|HTRA2,BAK1,NDUFAF4,COX15,OPA1,HCCS,CRLS1,ATP5F1A,TAMM41|
</modal>