====== Torin1 0.08μM R02 exp82 ======
==== Mechanism of Action ====
Inhibits mTORC1 and mTORC2, ATP competitive
  * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / mTOR inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / Kinase Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Torin 1%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1222998-36-8
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/49836027|49836027]]
    * **<color #00a2e8>IUPAC:</color>** %%1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
    * **<color #00a2e8>INCHI Key:</color>** AKCRNFFTGXBONI-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 607.6
    * **<color #00a2e8>Canonical SMILES:</color>** CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C35H28F3N5O2
{{:chemogenomics:structures:chem-0058.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Selleck Chemicals
    * **<color #00a2e8>Catalog #:</color>** S2827
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C35H28F3N5O2 608.22679; found 608.22884
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Torin1
    * **<color #00a2e8>Min:</color>** -11.3340; **<color #00a2e8>Max:</color>** 60.4301
{{:chemogenomics:dose_response:dr_24.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0460    |
| IC30  |0.0897    |
| IC40  |0.1551    |
| IC50  |0.2563    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 02
    * **<color #00a2e8>Dose</color>**: 80nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 3.7
    * **<color #00a2e8>Numbers of reads</color>**: 11967482


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/9|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Torin1_0.08uM_Round-2_exp82.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Torin1 0.08μM R02 exp82'>
{{:chemogenomics:cranks_plots:exp82.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:U:UMPS|UMPS]]|-3.24|0.33|
|[[:human_genes:T:THOC7|THOC7]]|-2.62|0.11|
|[[:human_genes:T:TUBB|TUBB]]|-2.62|0.22|
|[[:human_genes:U:UXS1|UXS1]]|-2.60|0.11|
|[[:human_genes:C:CDK6|CDK6]]|-2.49|0.13|
|[[:human_genes:M:MSH5|MSH5]]|-2.43|0.22|
|[[:human_genes:S:SAFB|SAFB]]|-2.31|0.38|
|[[:human_genes:P:PAG1|PAG1]]|-2.29|0.22|
|[[:human_genes:R:RRAGA|RRAGA]]|-2.25|0.38|
|[[:human_genes:D:DROSHA|DROSHA]]|-2.20|0.39|
|[[:human_genes:L:LAMTOR4|LAMTOR4]]|-2.12|0.38|
|[[:human_genes:R:RHEB|RHEB]]|-2.10|0.38|
|[[:human_genes:P:PACSIN2|PACSIN2]]|-2.08|0.38|
|[[:human_genes:Z:ZFP91|ZFP91]]|-2.07|0.38|
|[[:human_genes:T:TFAP2E|TFAP2E]]|-2.07|0.39|
|[[:human_genes:A:ADAM17|ADAM17]]|-2.06|0.39|
|[[:human_genes:M:MCM5|MCM5]]|-2.06|0.48|
|[[:human_genes:S:SLC9A3R1|SLC9A3R1]]|-2.06|0.38|
|[[:human_genes:N:NRAS|NRAS]]|-2.05|0.39|
|[[:human_genes:S:SCAPER|SCAPER]]|-2.05|0.39|
|[[:human_genes:S:SENP1|SENP1]]|-2.04|0.38|
|[[:human_genes:P:PSMA1|PSMA1]]|-2.04|0.65|
|[[:human_genes:R:RSRC2|RSRC2]]|-2.03|0.83|
|[[:human_genes:G:GTF2E2|GTF2E2]]|-2.03|0.39|
|[[:human_genes:U:U2AF2|U2AF2]]|-2.02|0.50|
|[[:human_genes:A:ACTL6A|ACTL6A]]|-2.01|0.65|
|[[:human_genes:N:NPIPA5|NPIPA5]]|-1.99|0.65|
|[[:human_genes:S:SCNN1G|SCNN1G]]|-1.97|0.39|
|[[:human_genes:C:CDC45|CDC45]]|-1.96|0.83|
|[[:human_genes:A:ACTB|ACTB]]|-1.96|0.50|
|[[:human_genes:D:DEFB135|DEFB135]]|2.10|0.24|
|[[:human_genes:C:CMAS|CMAS]]|2.11|0.20|
|[[:human_genes:K:KDM8|KDM8]]|2.12|0.34|
|[[:human_genes:M:MTHFD1|MTHFD1]]|2.12|0.49|
|[[:human_genes:C:COA6|COA6]]|2.13|0.18|
|[[:human_genes:M:MDH2|MDH2]]|2.14|0.22|
|[[:human_genes:M:MRPS18A|MRPS18A]]|2.14|0.22|
|[[:human_genes:P:PRKACA|PRKACA]]|2.18|0.15|
|[[:human_genes:E:EIF4A1|EIF4A1]]|2.22|0.20|
|[[:human_genes:A:ATIC|ATIC]]|2.22|0.20|
|[[:human_genes:M:MEMO1|MEMO1]]|2.22|0.13|
|[[:human_genes:N:NDUFAF3|NDUFAF3]]|2.25|0.24|
|[[:human_genes:W:WBSCR16|WBSCR16]]|2.34|0.21|
|[[:human_genes:A:ATP5F1|ATP5F1]]|2.37|0.12|
|[[:human_genes:T:TRMT6|TRMT6]]|2.45|0.08|
|[[:human_genes:K:KIAA0195|KIAA0195]]|2.46|0.08|
|[[:human_genes:P:PTPMT1|PTPMT1]]|2.48|0.22|
|[[:human_genes:G:GSK3A|GSK3A]]|2.49|0.04|
|[[:human_genes:G:GSK3B|GSK3B]]|2.53|0.04|
|[[:human_genes:A:ARID4B|ARID4B]]|2.55|0.06|
|[[:human_genes:B:BTK|BTK]]|2.57|0.06|
|[[:human_genes:I:IBA57|IBA57]]|2.59|0.03|
|[[:human_genes:M:MRPL28|MRPL28]]|2.69|0.07|
|[[:human_genes:F:FIBP|FIBP]]|2.78|0.03|
|[[:human_genes:M:METTL17|METTL17]]|2.85|0.03|
|[[:human_genes:P:PPP3R1|PPP3R1]]|2.85|0.01|
|[[:human_genes:P:PPP3CA|PPP3CA]]|2.92|<0.01|
|[[:human_genes:R:RPL36A-HNRNPH2|RPL36A-HNRNPH2]]|2.94|0.45|
|[[:human_genes:P:PGM3|PGM3]]|3.09|<0.01|
|[[:human_genes:E:EIF4EBP1|EIF4EBP1]]|3.51|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.054|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|0.116|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|0.071|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|0.063|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|0.062|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|0.056|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|0.055|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|0.054|<button type="primary" size="small" modal="8">View</button>|
</modal>


<modal id="1" size="lg" title="Torin1 0.08μM R02 exp82  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp82.png?nolink |}}
</modal>

<modal id="2" size="lg" title="INK128 0.2μM R02 exp70  vs  Torin1 0.08μM R02 exp82">
{{:chemogenomics:comparison_plots:exp70_vs_exp82.png?nolink |}}
</modal>

<modal id="3" size="lg" title="KU-0063794 3.8μM R02 exp71  vs  Torin1 0.08μM R02 exp82">
{{:chemogenomics:comparison_plots:exp71_vs_exp82.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Rapamycin 0.001μM R08 exp429  vs  Torin1 0.08μM R02 exp82">
{{:chemogenomics:comparison_plots:exp429_vs_exp82.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Rapamycin 2μM R07 exp306  vs  Torin1 0.08μM R02 exp82">
{{:chemogenomics:comparison_plots:exp306_vs_exp82.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Rapamycin 10μM R00 exp30  vs  Torin1 0.08μM R02 exp82">
{{:chemogenomics:comparison_plots:exp30_vs_exp82.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Rapamycin 1μM R00 exp29  vs  Torin1 0.08μM R02 exp82">
{{:chemogenomics:comparison_plots:exp29_vs_exp82.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Erlotinib 10μM R05 exp216  vs  Torin1 0.08μM R02 exp82">
{{:chemogenomics:comparison_plots:exp216_vs_exp82.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>