====== UM0125461 0.74μM R02 exp84 ======
==== Mechanism of Action ====
Unknown
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 331.41
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C22H21NO2
{{:chemogenomics:structures:chem-0060.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** In house - University of Montreal - Chemistry Platform
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** IRIC-009 / JFL-1031-09-03 / Batch #01
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C22H21NO2 332.16451; found 332.16494
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** UM125461
    * **<color #00a2e8>Min:</color>** -1.6125; **<color #00a2e8>Max:</color>** 98.9160
{{:chemogenomics:dose_response:dr_25.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.4802    |
| IC30  |0.7716    |
| IC40  |1.1382    |
| IC50  |1.6261    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 02
    * **<color #00a2e8>Dose</color>**: 740nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 3.6
    * **<color #00a2e8>Numbers of reads</color>**: 11991596


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|40/100|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/UM0125461_0.74uM_Round-2_exp84.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='UM0125461 0.74μM R02 exp84'>
{{:chemogenomics:cranks_plots:exp84.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ACSL4|ACSL4]]|-4.57|<0.01|
|[[:human_genes:D:DEPDC5|DEPDC5]]|-3.40|<0.01|
|[[:human_genes:T:TMEM189|TMEM189]]|-3.32|<0.01|
|[[:human_genes:A:ACSL3|ACSL3]]|-3.26|<0.01|
|[[:human_genes:S:SPTLC2|SPTLC2]]|-3.22|<0.01|
|[[:human_genes:L:LDLRAP1|LDLRAP1]]|-3.16|<0.01|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-3.02|<0.01|
|[[:human_genes:N:NGLY1|NGLY1]]|-2.97|<0.01|
|[[:human_genes:C:C1orf43|C1orf43]]|-2.96|<0.01|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.93|0.01|
|[[:human_genes:L:LDLR|LDLR]]|-2.93|<0.01|
|[[:human_genes:M:MSI2|MSI2]]|-2.89|<0.01|
|[[:human_genes:S:SNAPC5|SNAPC5]]|-2.87|<0.01|
|[[:human_genes:P:PRMT7|PRMT7]]|-2.85|<0.01|
|[[:human_genes:C:C10orf76|C10orf76]]|-2.85|<0.01|
|[[:human_genes:E:EIF2S1|EIF2S1]]|-2.84|0.14|
|[[:human_genes:C:C7orf26|C7orf26]]|-2.83|<0.01|
|[[:human_genes:C:CNOT2|CNOT2]]|-2.75|<0.01|
|[[:human_genes:P:PEX1|PEX1]]|-2.75|<0.01|
|[[:human_genes:F:FBXW7|FBXW7]]|-2.72|<0.01|
|[[:human_genes:S:SPG7|SPG7]]|-2.70|0.01|
|[[:human_genes:S:SESN2|SESN2]]|-2.66|<0.01|
|[[:human_genes:T:TMEM189-UBE2V1|TMEM189-UBE2V1]]|-2.65|<0.01|
|[[:human_genes:B:BSCL2|BSCL2]]|-2.65|0.03|
|[[:human_genes:P:PCYT2|PCYT2]]|-2.59|0.02|
|[[:human_genes:I:ITPK1|ITPK1]]|-2.57|0.01|
|[[:human_genes:L:LRRN3|LRRN3]]|-2.54|0.01|
|[[:human_genes:N:NPRL2|NPRL2]]|-2.53|0.01|
|[[:human_genes:H:HEXIM1|HEXIM1]]|-2.51|0.01|
|[[:human_genes:Z:ZNF708|ZNF708]]|-2.51|0.03|
|[[:human_genes:M:MRPS34|MRPS34]]|2.78|<0.01|
|[[:human_genes:R:RPUSD4|RPUSD4]]|2.79|<0.01|
|[[:human_genes:M:MIPEP|MIPEP]]|2.81|<0.01|
|[[:human_genes:A:ABCG1|ABCG1]]|2.81|<0.01|
|[[:human_genes:C:CELF2|CELF2]]|2.82|<0.01|
|[[:human_genes:F:FASTKD2|FASTKD2]]|2.83|<0.01|
|[[:human_genes:P:PIH1D1|PIH1D1]]|2.84|<0.01|
|[[:human_genes:K:KCTD5|KCTD5]]|2.85|<0.01|
|[[:human_genes:N:NDUFAF5|NDUFAF5]]|2.85|<0.01|
|[[:human_genes:P:PGP|PGP]]|3.02|0.00|
|[[:human_genes:S:STRAP|STRAP]]|3.06|0.00|
|[[:human_genes:C:COA3|COA3]]|3.08|<0.01|
|[[:human_genes:P:PFKP|PFKP]]|3.11|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|3.11|0.00|
|[[:human_genes:P:PET117|PET117]]|3.16|0.00|
|[[:human_genes:H:HSD17B10|HSD17B10]]|3.21|0.00|
|[[:human_genes:I:IBA57|IBA57]]|3.29|0.00|
|[[:human_genes:A:AHCYL1|AHCYL1]]|3.40|0.00|
|[[:human_genes:A:ALAS1|ALAS1]]|3.41|0.00|
|[[:human_genes:T:TRIT1|TRIT1]]|3.44|0.00|
|[[:human_genes:H:HMBS|HMBS]]|3.55|0.00|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.58|0.00|
|[[:human_genes:T:TMEM208|TMEM208]]|3.66|0.00|
|[[:human_genes:M:MARCH5|MARCH5]]|3.89|0.00|
|[[:human_genes:M:MBNL1|MBNL1]]|3.93|0.00|
|[[:human_genes:E:ELOVL6|ELOVL6]]|3.96|0.00|
|[[:human_genes:N:NFRKB|NFRKB]]|4.10|0.00|
|[[:human_genes:U:UCHL5|UCHL5]]|4.87|0.00|
|[[:human_genes:A:ATIC|ATIC]]|4.91|0.00|
|[[:human_genes:F:FADS2|FADS2]]|5.01|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|0.07|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|0.068|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.056|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.149|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.13|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.12|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|0.118|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.097|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|0.094|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp360|Genistein 15μM R07 exp360]]|0.084|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|0.079|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.077|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|0.069|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.067|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.066|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.065|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.065|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.063|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|0.062|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.061|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|0.061|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|0.061|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.057|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|0.057|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|0.056|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.053|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.051|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.051|<button type="primary" size="small" modal="28">View</button>|
</modal>


<modal id="1" size="lg" title="UM0125461 0.74μM R02 exp84  vs  Vemurafenib 6.6μM R02 exp89">
{{:chemogenomics:comparison_plots:exp84_vs_exp89.png?nolink |}}
</modal>

<modal id="2" size="lg" title="UM0125461 0.74μM R02 exp84  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp84.png?nolink |}}
</modal>

<modal id="3" size="lg" title="UM0125461 0.74μM R02 exp84  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp84.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Tubacin 1.6μM R07 exp416  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp416_vs_exp84.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp329_vs_exp84.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Thimerosal 0.85μM R08 exp529  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp529_vs_exp84.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Oligomycin-A 2μM R00 exp25  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp25_vs_exp84.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Artemisinin 50μM R08 exp450  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp450_vs_exp84.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Pterostilbene 16μM R02 exp78  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp78_vs_exp84.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Genistein 15μM R07 exp360  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp360_vs_exp84.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Dynasore 10μM R04 exp180  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp180_vs_exp84.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Deferoxamine 11μM R07 exp350  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp350_vs_exp84.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Q15 2.7μM R02 exp79  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp79_vs_exp84.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Quercetin 20μM R08 exp517  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp517_vs_exp84.png?nolink |}}
</modal>

<modal id="15" size="lg" title="GSK-J4 1.5μM R08 exp441  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp441_vs_exp84.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp440_vs_exp84.png?nolink |}}
</modal>

<modal id="17" size="lg" title="LLY-283 2.6μM R06 exp290  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp290_vs_exp84.png?nolink |}}
</modal>

<modal id="18" size="lg" title="PU-H71 1μM R08 exp515  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp515_vs_exp84.png?nolink |}}
</modal>

<modal id="19" size="lg" title="BI-D1870 3.15μM R02 exp66  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp66_vs_exp84.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp164_vs_exp84.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Dynasore 7μM R08 exp436  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp436_vs_exp84.png?nolink |}}
</modal>

<modal id="22" size="lg" title="HMS-I2 10μM R06 exp288  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp288_vs_exp84.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Atovaquone 15μM R08 exp451  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp451_vs_exp84.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Arsenate 40μM R06 exp264  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp264_vs_exp84.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp356_vs_exp84.png?nolink |}}
</modal>

<modal id="26" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp500_vs_exp84.png?nolink |}}
</modal>

<modal id="27" size="lg" title="CB-5083 0.4μM R08 exp468  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp468_vs_exp84.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Tanespimycin 14μM R08 exp527  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp527_vs_exp84.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|GATOR1 complex|691.00|NPRL3,NPRL2|
|palmitoyl-CoA ligase activity|691.00|ACSL4,ACSL3|
|Seh1-associated complex|296.14|DEPDC5,NPRL3,NPRL2|
|negative regulation of TORC1 signaling|84.27|DEPDC5,PRKAA1,NPRL3,SESN2,NPRL2|
|cellular response to amino acid starvation|71.98|DEPDC5,NPRL3,EIF2S1,SESN2,NPRL2|
|response to amino acid starvation|67.75|DEPDC5,NPRL3,EIF2S1,SESN2,NPRL2|
|negative regulation of TOR signaling|52.35|DEPDC5,PRKAA1,NPRL3,SESN2,NPRL2|
|regulation of TORC1 signaling|40.17|DEPDC5,PRKAA1,NPRL3,SESN2,NPRL2|
|positive regulation of autophagy|28.40|DEPDC5,SPTLC2,PRKAA1,NPRL3,SESN2,NPRL2|
|regulation of TOR signaling|25.59|DEPDC5,PRKAA1,NPRL3,SESN2,NPRL2|
|cellular response to starvation|24.25|DEPDC5,PRKAA1,NPRL3,EIF2S1,SESN2,NPRL2|
|lipid homeostasis|22.29|LDLRAP1,PRKAA1,LDLR,FBXW7,SESN2|
|response to starvation|19.74|DEPDC5,PRKAA1,NPRL3,EIF2S1,SESN2,NPRL2|
|cellular response to nutrient levels|17.79|DEPDC5,PRKAA1,NPRL3,EIF2S1,SESN2,NPRL2|
|cellular response to extracellular stimulus|15.82|DEPDC5,PRKAA1,NPRL3,EIF2S1,SESN2,NPRL2|
|positive regulation of cellular catabolic process|15.45|DEPDC5,SPTLC2,PRKAA1,NPRL3,CNOT2,SESN2,NPRL2|
|regulation of autophagy|13.90|DEPDC5,SPTLC2,PRKAA1,NPRL3,FBXW7,SESN2,NPRL2|
|positive regulation of catabolic process|12.08|DEPDC5,SPTLC2,PRKAA1,NPRL3,LDLR,CNOT2,FBXW7,SESN2,NPRL2|
|regulation of cellular catabolic process|9.66|DEPDC5,SPTLC2,PRKAA1,NPRL3,LDLR,CNOT2,FBXW7,SESN2,NPRL2|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|mitochondrial RNA modification|184.27|TRIT1,HSD17B10,RPUSD4|
|mitochondrial tRNA processing|127.57|TRIT1,HSD17B10,RPUSD4|
|positive regulation of mitochondrial translation|110.56|COA3,FASTKD2,RPUSD4|
|mitochondrial RNA processing|110.56|TRIT1,HSD17B10,FASTKD2,RPUSD4|
|tRNA threonylcarbamoyladenosine metabolic process|97.55|TRIT1,HSD17B10,RPUSD4|
|heme biosynthetic process|66.34|HMBS,ALAS1,IBA57|
|porphyrin-containing compound biosynthetic process|59.23|HMBS,ALAS1,IBA57|
|regulation of mitochondrial gene expression|59.23|COA3,FASTKD2,RPUSD4|
|tetrapyrrole biosynthetic process|59.23|HMBS,ALAS1,IBA57|
|mitochondrial RNA metabolic process|51.42|TRIT1,HSD17B10,FASTKD2,RPUSD4|
|mitochondrial gene expression|19.88|TRIT1,HSD17B10,FASTKD2,RPUSD4,MRPS34|
|mitochondrial matrix|9.31|TRIT1,ALAS1,IBA57,HSD17B10,FASTKD2,MIPEP,RPUSD4,MRPS34|
|RNA processing|5.97|MBNL1,TRIT1,AHCYL1,HSD17B10,STRAP,PIH1D1,FASTKD2,CELF2,RPUSD4|
</modal>