======= AACS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AACS
  * **<color #00a2e8>Official Name</color>**: acetoacetyl-CoA synthetase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65985|65985]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86V21|Q86V21]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AACS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AACS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614364|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AMP-binding|
|DUF3448|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetoacetate-CoA ligase activity|
|response to oleic acid|
|butyrate-CoA ligase activity|
|cellular response to testosterone stimulus|
|ketone body biosynthetic process|
|cellular ketone body metabolic process|
|ketone body metabolic process|
|white fat cell differentiation|
|cellular response to cholesterol|
|cellular response to sterol|
|response to cholesterol|
|response to sterol|
|adipose tissue development|
|response to testosterone|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|positive regulation of insulin secretion|
|cellular response to carbohydrate stimulus|
|response to fatty acid|
|cellular response to alcohol|
|cellular glucose homeostasis|
|fatty acid derivative biosynthetic process|
|cellular response to ketone|
|positive regulation of peptide hormone secretion|
|fat cell differentiation|
|liver development|
|response to ethanol|
|positive regulation of hormone secretion|
|hepaticobiliary system development|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|response to purine-containing compound|
|fatty acid derivative metabolic process|
|response to carbohydrate|
|regulation of insulin secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to starvation|
|response to ketone|
|regulation of peptide hormone secretion|
|response to nutrient|
|connective tissue development|
|response to alcohol|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|response to antibiotic|
|fatty acid metabolic process|
|response to acid chemical|
|positive regulation of secretion by cell|
|gland development|
|generation of precursor metabolites and energy|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|response to nutrient levels|
|drug metabolic process|
|response to toxic substance|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|regulation of protein transport|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|response to lipid|
|cellular homeostasis|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|positive regulation of transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.71|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.73|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5662
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AACS Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>