======= AARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AARS1
  * **<color #00a2e8>Official Name</color>**: alanyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=16|16]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49588|P49588]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601065|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:28493438). {ECO:0000255|HAMAP- Rule:MF_03133, ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 2c|
|DHHA1|
|tRNA SAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cytoplasmic translational fidelity|
|Ser-tRNA(Ala) hydrolase activity|
|alanyl-tRNA aminoacylation|
|alanine-tRNA ligase activity|
|regulation of cytoplasmic translational elongation|
|aminoacyl-tRNA editing activity|
|aminoacyl-tRNA metabolism involved in translational fidelity|
|amino acid binding|
|translation regulator activity|
|regulation of translational elongation|
|regulation of translational fidelity|
|cerebellar Purkinje cell layer development|
|regulation of cytoplasmic translation|
|tRNA aminoacylation for protein translation|
|cerebellar cortex development|
|tRNA aminoacylation|
|amino acid activation|
|neuromuscular process controlling balance|
|tRNA binding|
|tRNA modification|
|cerebellum development|
|neuromuscular process|
|metencephalon development|
|tRNA processing|
|negative regulation of neuron apoptotic process|
|hindbrain development|
|RNA modification|
|tRNA metabolic process|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|cellular amino acid metabolic process|
|regulation of neuron death|
|regulation of translation|
|translation|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|brain development|
|head development|
|cellular amide metabolic process|
|zinc ion binding|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|central nervous system development|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|nervous system process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|system process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.81|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.84|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.86|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.93|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.07|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccdc101|CCDC101]]|0.62|
|[[:human genes:t:tti2|TTI2]]|0.617|
|[[:human genes:r:rnmt|RNMT]]|0.597|
|[[:human genes:g:gmppb|GMPPB]]|0.59|
|[[:human genes:e:eif4e|EIF4E]]|0.582|
|[[:human genes:p:pelo|PELO]]|0.58|
|[[:human genes:h:hars|HARS]]|0.569|
|[[:human genes:r:rptor|RPTOR]]|0.566|
|[[:human genes:r:rtcb|RTCB]]|0.566|
|[[:human genes:p:pmm2|PMM2]]|0.565|
|[[:human genes:c:cct7|CCT7]]|0.561|
|[[:human genes:m:med16|MED16]]|0.56|
|[[:human genes:t:triap1|TRIAP1]]|0.559|
|[[:human genes:m:med23|MED23]]|0.555|
|[[:human genes:t:tti1|TTI1]]|0.555|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.548|
|[[:human genes:n:nars|NARS]]|0.544|
|[[:human genes:d:dpagt1|DPAGT1]]|0.539|
|[[:human genes:m:mapk14|MAPK14]]|0.537|
|[[:human genes:g:gnb1l|GNB1L]]|0.536|
|[[:human genes:h:hspd1|HSPD1]]|0.534|
|[[:human genes:t:telo2|TELO2]]|0.534|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.532|
|[[:human genes:g:gfpt1|GFPT1]]|0.531|
|[[:human genes:o:otud5|OTUD5]]|0.53|
|[[:human genes:m:meaf6|MEAF6]]|0.529|
|[[:human genes:a:alg5|ALG5]]|0.529|
|[[:human genes:a:alg1|ALG1]]|0.528|
|[[:human genes:v:vrk1|VRK1]]|0.528|
|[[:human genes:n:nae1|NAE1]]|0.524|
|[[:human genes:a:alg2|ALG2]]|0.523|
|[[:human genes:e:eprs|EPRS]]|0.514|
|[[:human genes:t:taz|TAZ]]|0.512|
|[[:human genes:t:thg1l|THG1L]]|0.512|
|[[:human genes:m:mtor|MTOR]]|0.511|
|[[:human genes:t:tle4|TLE4]]|0.509|
|[[:human genes:s:slc35b1|SLC35B1]]|0.508|
|[[:human genes:p:pam16|PAM16]]|0.505|
|[[:human genes:c:cbfb|CBFB]]|0.504|
|[[:human genes:u:uap1|UAP1]]|0.504|
|[[:human genes:p:pggt1b|PGGT1B]]|0.501|
|[[:human genes:s:spcs3|SPCS3]]|0.5|
|[[:human genes:a:alg13|ALG13]]|0.498|
|[[:human genes:m:mllt1|MLLT1]]|0.498|
|[[:human genes:y:yars|YARS]]|0.497|
|[[:human genes:w:wdr24|WDR24]]|0.496|
|[[:human genes:c:csnk2b|CSNK2B]]|0.495|
|[[:human genes:t:trmt5|TRMT5]]|0.492|
|[[:human genes:s:srp14|SRP14]]|0.491|
|[[:human genes:m:mars|MARS]]|0.49|
|[[:human genes:s:srp68|SRP68]]|0.488|
|[[:human genes:d:ddost|DDOST]]|0.487|
|[[:human genes:s:seh1l|SEH1L]]|0.486|
|[[:human genes:r:rpn1|RPN1]]|0.486|
|[[:human genes:s:srp72|SRP72]]|0.485|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.483|
|[[:human genes:e:exoc4|EXOC4]]|0.48|
|[[:human genes:a:alg14|ALG14]]|0.48|
|[[:human genes:d:dohh|DOHH]]|0.48|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.474|
|[[:human genes:t:tamm41|TAMM41]]|0.472|
|[[:human genes:p:ppp4c|PPP4C]]|0.472|
|[[:human genes:t:tbp|TBP]]|0.468|
|[[:human genes:b:bap1|BAP1]]|0.466|
|[[:human genes:t:tsen34|TSEN34]]|0.464|
|[[:human genes:o:osgep|OSGEP]]|0.464|
|[[:human genes:p:pik3r4|PIK3R4]]|0.462|
|[[:human genes:d:dpf2|DPF2]]|0.462|
|[[:human genes:a:atxn10|ATXN10]]|0.462|
|[[:human genes:d:dhx29|DHX29]]|0.46|
|[[:human genes:v:vmp1|VMP1]]|0.46|
|[[:human genes:m:med4|MED4]]|0.459|
|[[:human genes:p:polr3h|POLR3H]]|0.458|
|[[:human genes:a:atp5j|ATP5J]]|0.457|
|[[:human genes:t:tsen54|TSEN54]]|0.457|
|[[:human genes:n:nup50|NUP50]]|0.457|
|[[:human genes:f:fnta|FNTA]]|0.456|
|[[:human genes:i:id3|ID3]]|0.454|
|[[:human genes:n:nsmce2|NSMCE2]]|0.451|
|[[:human genes:d:dad1|DAD1]]|0.451|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.45|
|[[:human genes:d:dhps|DHPS]]|0.449|
|[[:human genes:u:ube2l3|UBE2L3]]|0.448|
|[[:human genes:r:rpe|RPE]]|0.447|
|[[:human genes:t:tsen2|TSEN2]]|0.444|
|[[:human genes:p:polr3b|POLR3B]]|0.444|
|[[:human genes:t:thoc6|THOC6]]|0.444|
|[[:human genes:d:dhdds|DHDDS]]|0.443|
|[[:human genes:u:uxt|UXT]]|0.442|
|[[:human genes:e:eny2|ENY2]]|0.44|
|[[:human genes:s:smarcd1|SMARCD1]]|0.44|
|[[:human genes:g:gfer|GFER]]|0.439|
|[[:human genes:c:cbx3|CBX3]]|0.439|
|[[:human genes:d:ddx20|DDX20]]|0.438|
|[[:human genes:z:znf259|ZNF259]]|0.435|
|[[:human genes:h:haus8|HAUS8]]|0.435|
|[[:human genes:t:tbca|TBCA]]|0.435|
|[[:human genes:a:adsl|ADSL]]|0.435|
|[[:human genes:r:rpp21|RPP21]]|0.434|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.432|
|[[:human genes:p:pisd|PISD]]|0.432|
|[[:human genes:p:pax5|PAX5]]|0.431|
|[[:human genes:t:tmem41b|TMEM41B]]|0.429|
|[[:human genes:d:dctn6|DCTN6]]|0.428|
|[[:human genes:t:trnt1|TRNT1]]|0.427|
|[[:human genes:s:spcs2|SPCS2]]|0.427|
|[[:human genes:s:sec61g|SEC61G]]|0.427|
|[[:human genes:m:max|MAX]]|0.426|
|[[:human genes:r:rbm14|RBM14]]|0.426|
|[[:human genes:u:ube2g2|UBE2G2]]|0.426|
|[[:human genes:n:naa20|NAA20]]|0.423|
|[[:human genes:n:nsmce1|NSMCE1]]|0.422|
|[[:human genes:l:lsmd1|LSMD1]]|0.421|
|[[:human genes:a:atp5b|ATP5B]]|0.42|
|[[:human genes:e:eef1e1|EEF1E1]]|0.42|
|[[:human genes:e:eno1|ENO1]]|0.419|
|[[:human genes:n:nxt1|NXT1]]|0.418|
|[[:human genes:a:atf7ip|ATF7IP]]|0.418|
|[[:human genes:u:uhrf1|UHRF1]]|0.418|
|[[:human genes:t:trim28|TRIM28]]|0.415|
|[[:human genes:r:rad1|RAD1]]|0.412|
|[[:human genes:c:cars|CARS]]|0.412|
|[[:human genes:v:vezt|VEZT]]|0.411|
|[[:human genes:d:dnajb11|DNAJB11]]|0.411|
|[[:human genes:r:rnf126|RNF126]]|0.41|
|[[:human genes:t:tprkb|TPRKB]]|0.41|
|[[:human genes:a:alg6|ALG6]]|0.41|
|[[:human genes:g:gemin5|GEMIN5]]|0.407|
|[[:human genes:t:txnrd1|TXNRD1]]|0.406|
|[[:human genes:c:crls1|CRLS1]]|0.405|
|[[:human genes:u:uba3|UBA3]]|0.404|
|[[:human genes:t:tada1|TADA1]]|0.403|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.403|
|[[:human genes:d:dnajc3|DNAJC3]]|0.402|
|[[:human genes:a:arih1|ARIH1]]|0.401|
|[[:human genes:t:tmed10|TMED10]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 542
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AARS Expression in NALM6 Cells: 7.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>