======= AARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AARS2
  * **<color #00a2e8>Official Name</color>**: alanyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57505|57505]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JTZ9|Q5JTZ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. {ECO:0000255|HAMAP-Rule:MF_03133}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA SAD|
|tRNA-synt 2c|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial alanyl-tRNA aminoacylation|
|alanyl-tRNA aminoacylation|
|alanine-tRNA ligase activity|
|tRNA aminoacylation for mitochondrial protein translation|
|aminoacyl-tRNA editing activity|
|aminoacyl-tRNA metabolism involved in translational fidelity|
|amino acid binding|
|regulation of translational fidelity|
|mitochondrial RNA metabolic process|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|tRNA modification|
|mitochondrial respiratory chain complex assembly|
|mitochondrial translation|
|tRNA processing|
|mitochondrial gene expression|
|RNA modification|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|mitochondrion organization|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|zinc ion binding|
|cellular protein-containing complex assembly|
|RNA processing|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.71|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.71|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.71|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.71|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.74|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.76|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.77|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.82|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.16|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.68|
|[[:human genes:q:qrsl1|QRSL1]]|0.676|
|[[:human genes:l:lars2|LARS2]]|0.669|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.656|
|[[:human genes:s:selrc1|SELRC1]]|0.646|
|[[:human genes:e:ears2|EARS2]]|0.642|
|[[:human genes:t:tars2|TARS2]]|0.641|
|[[:human genes:s:sco2|SCO2]]|0.633|
|[[:human genes:d:dap3|DAP3]]|0.622|
|[[:human genes:p:polg2|POLG2]]|0.62|
|[[:human genes:g:gfm1|GFM1]]|0.619|
|[[:human genes:p:pars2|PARS2]]|0.615|
|[[:human genes:c:coa3|COA3]]|0.615|
|[[:human genes:f:ftsj2|FTSJ2]]|0.612|
|[[:human genes:c:cox11|COX11]]|0.611|
|[[:human genes:v:vars2|VARS2]]|0.611|
|[[:human genes:p:pet112|PET112]]|0.61|
|[[:human genes:y:yars2|YARS2]]|0.61|
|[[:human genes:r:rars2|RARS2]]|0.608|
|[[:human genes:m:mrps34|MRPS34]]|0.607|
|[[:human genes:p:pet117|PET117]]|0.606|
|[[:human genes:m:mrpl23|MRPL23]]|0.605|
|[[:human genes:m:mrps26|MRPS26]]|0.597|
|[[:human genes:m:mrpl21|MRPL21]]|0.582|
|[[:human genes:m:mrps21|MRPS21]]|0.582|
|[[:human genes:m:mars2|MARS2]]|0.581|
|[[:human genes:m:mrpl53|MRPL53]]|0.58|
|[[:human genes:w:wars2|WARS2]]|0.577|
|[[:human genes:m:mtg2|MTG2]]|0.576|
|[[:human genes:m:mrpl45|MRPL45]]|0.575|
|[[:human genes:r:rpusd3|RPUSD3]]|0.571|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.57|
|[[:human genes:g:gfm2|GFM2]]|0.569|
|[[:human genes:d:dars2|DARS2]]|0.569|
|[[:human genes:m:mettl17|METTL17]]|0.568|
|[[:human genes:m:mrps16|MRPS16]]|0.566|
|[[:human genes:f:fastkd5|FASTKD5]]|0.561|
|[[:human genes:h:hars2|HARS2]]|0.56|
|[[:human genes:r:rpusd4|RPUSD4]]|0.559|
|[[:human genes:m:mrpl3|MRPL3]]|0.556|
|[[:human genes:e:eral1|ERAL1]]|0.556|
|[[:human genes:m:mtg1|MTG1]]|0.556|
|[[:human genes:m:mrps14|MRPS14]]|0.555|
|[[:human genes:m:mrps12|MRPS12]]|0.553|
|[[:human genes:c:cox16|COX16]]|0.55|
|[[:human genes:m:mrps6|MRPS6]]|0.55|
|[[:human genes:c:coa6|COA6]]|0.544|
|[[:human genes:n:nsun4|NSUN4]]|0.543|
|[[:human genes:w:wbscr16|WBSCR16]]|0.541|
|[[:human genes:g:gatc|GATC]]|0.54|
|[[:human genes:f:fars2|FARS2]]|0.537|
|[[:human genes:m:mrpl4|MRPL4]]|0.535|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.535|
|[[:human genes:n:ndufs2|NDUFS2]]|0.532|
|[[:human genes:n:ndufb11|NDUFB11]]|0.532|
|[[:human genes:m:mrpl47|MRPL47]]|0.528|
|[[:human genes:m:mrp63|MRP63]]|0.525|
|[[:human genes:m:malsu1|MALSU1]]|0.52|
|[[:human genes:m:mrps24|MRPS24]]|0.518|
|[[:human genes:m:mrps25|MRPS25]]|0.515|
|[[:human genes:m:mrps27|MRPS27]]|0.513|
|[[:human genes:p:polrmt|POLRMT]]|0.512|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.512|
|[[:human genes:c:c10orf2|C10orf2]]|0.511|
|[[:human genes:m:mrps35|MRPS35]]|0.511|
|[[:human genes:r:rbfa|RBFA]]|0.511|
|[[:human genes:m:mipep|MIPEP]]|0.508|
|[[:human genes:m:mrps2|MRPS2]]|0.506|
|[[:human genes:t:tomm20|TOMM20]]|0.506|
|[[:human genes:m:mrps5|MRPS5]]|0.504|
|[[:human genes:b:bcs1l|BCS1L]]|0.501|
|[[:human genes:c:cox20|COX20]]|0.501|
|[[:human genes:p:pgm3|PGM3]]|0.499|
|[[:human genes:m:mrpl49|MRPL49]]|0.496|
|[[:human genes:a:aifm1|AIFM1]]|0.495|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.495|
|[[:human genes:n:ndufa3|NDUFA3]]|0.493|
|[[:human genes:a:acad9|ACAD9]]|0.492|
|[[:human genes:m:mrps22|MRPS22]]|0.491|
|[[:human genes:m:mcat|MCAT]]|0.489|
|[[:human genes:c:coq2|COQ2]]|0.488|
|[[:human genes:c:cars2|CARS2]]|0.488|
|[[:human genes:t:tfb1m|TFB1M]]|0.487|
|[[:human genes:m:mrpl20|MRPL20]]|0.485|
|[[:human genes:m:mtif2|MTIF2]]|0.485|
|[[:human genes:m:mrpl12|MRPL12]]|0.484|
|[[:human genes:m:mrpl39|MRPL39]]|0.483|
|[[:human genes:m:mrps10|MRPS10]]|0.483|
|[[:human genes:c:cox7b|COX7B]]|0.483|
|[[:human genes:m:mtpap|MTPAP]]|0.482|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.48|
|[[:human genes:t:tefm|TEFM]]|0.48|
|[[:human genes:m:mrpl2|MRPL2]]|0.479|
|[[:human genes:m:mrpl18|MRPL18]]|0.479|
|[[:human genes:m:mrps9|MRPS9]]|0.477|
|[[:human genes:c:cox15|COX15]]|0.477|
|[[:human genes:n:ndufa1|NDUFA1]]|0.476|
|[[:human genes:n:ndufv1|NDUFV1]]|0.474|
|[[:human genes:e:ecsit|ECSIT]]|0.473|
|[[:human genes:m:mrps23|MRPS23]]|0.473|
|[[:human genes:m:mterfd2|MTERFD2]]|0.473|
|[[:human genes:m:mrps18a|MRPS18A]]|0.472|
|[[:human genes:d:ddx28|DDX28]]|0.471|
|[[:human genes:c:c12orf65|C12orf65]]|0.469|
|[[:human genes:n:ndufb6|NDUFB6]]|0.467|
|[[:human genes:m:mrpl37|MRPL37]]|0.467|
|[[:human genes:m:mrpl17|MRPL17]]|0.465|
|[[:human genes:t:tfb2m|TFB2M]]|0.465|
|[[:human genes:n:ndufa2|NDUFA2]]|0.463|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.46|
|[[:human genes:l:lrpprc|LRPPRC]]|0.458|
|[[:human genes:p:polg|POLG]]|0.457|
|[[:human genes:n:ndufc2|NDUFC2]]|0.457|
|[[:human genes:t:trub2|TRUB2]]|0.456|
|[[:human genes:m:mrpl43|MRPL43]]|0.455|
|[[:human genes:n:ndufb9|NDUFB9]]|0.454|
|[[:human genes:m:mrps7|MRPS7]]|0.454|
|[[:human genes:c:chchd1|CHCHD1]]|0.453|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.453|
|[[:human genes:s:ssbp1|SSBP1]]|0.452|
|[[:human genes:d:dnlz|DNLZ]]|0.449|
|[[:human genes:m:mrpl44|MRPL44]]|0.448|
|[[:human genes:m:mrpl15|MRPL15]]|0.446|
|[[:human genes:m:mrpl51|MRPL51]]|0.445|
|[[:human genes:s:slc25a3|SLC25A3]]|0.441|
|[[:human genes:n:ndufb7|NDUFB7]]|0.44|
|[[:human genes:t:tomm6|TOMM6]]|0.44|
|[[:human genes:m:mrpl33|MRPL33]]|0.439|
|[[:human genes:c:coq3|COQ3]]|0.439|
|[[:human genes:t:tmem242|TMEM242]]|0.437|
|[[:human genes:m:mto1|MTO1]]|0.436|
|[[:human genes:s:sars2|SARS2]]|0.435|
|[[:human genes:p:pnpt1|PNPT1]]|0.435|
|[[:human genes:f:fastkd2|FASTKD2]]|0.435|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.435|
|[[:human genes:m:mrpl42|MRPL42]]|0.431|
|[[:human genes:p:ptcd1|PTCD1]]|0.43|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.429|
|[[:human genes:m:mterfd1|MTERFD1]]|0.429|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.429|
|[[:human genes:m:mrps28|MRPS28]]|0.428|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.428|
|[[:human genes:c:c1qbp|C1QBP]]|0.426|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.426|
|[[:human genes:n:ndufa10|NDUFA10]]|0.425|
|[[:human genes:m:mettl1|METTL1]]|0.425|
|[[:human genes:g:grsf1|GRSF1]]|0.424|
|[[:human genes:m:mrps18b|MRPS18B]]|0.422|
|[[:human genes:c:c17orf89|C17orf89]]|0.422|
|[[:human genes:t:tufm|TUFM]]|0.422|
|[[:human genes:n:ndufs5|NDUFS5]]|0.42|
|[[:human genes:a:atp5sl|ATP5SL]]|0.419|
|[[:human genes:n:ndufb5|NDUFB5]]|0.419|
|[[:human genes:n:ndufa11|NDUFA11]]|0.419|
|[[:human genes:t:trmt61a|TRMT61A]]|0.419|
|[[:human genes:m:mrpl55|MRPL55]]|0.418|
|[[:human genes:m:mrpl28|MRPL28]]|0.418|
|[[:human genes:t:tfam|TFAM]]|0.417|
|[[:human genes:u:uqcc1|UQCC1]]|0.417|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.416|
|[[:human genes:p:ptcd3|PTCD3]]|0.414|
|[[:human genes:u:uqcc2|UQCC2]]|0.414|
|[[:human genes:c:cox6b1|COX6B1]]|0.413|
|[[:human genes:m:mtif3|MTIF3]]|0.412|
|[[:human genes:n:ndufv2|NDUFV2]]|0.411|
|[[:human genes:n:nubpl|NUBPL]]|0.411|
|[[:human genes:m:mrpl35|MRPL35]]|0.409|
|[[:human genes:a:atp5c1|ATP5C1]]|0.409|
|[[:human genes:i:iba57|IBA57]]|0.409|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.407|
|[[:human genes:c:coq7|COQ7]]|0.407|
|[[:human genes:c:cox4i1|COX4I1]]|0.407|
|[[:human genes:s:sco1|SCO1]]|0.407|
|[[:human genes:m:mrpl52|MRPL52]]|0.406|
|[[:human genes:s:slc25a51|SLC25A51]]|0.404|
|[[:human genes:p:pitrm1|PITRM1]]|0.404|
|[[:human genes:c:clpp|CLPP]]|0.403|
|[[:human genes:h:higd2a|HIGD2A]]|0.401|
|[[:human genes:i:ict1|ICT1]]|0.401|
|[[:human genes:n:ndufb10|NDUFB10]]|0.401|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 110/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|5/26|
|breast|10/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|5/20|
|lung|9/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1721
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AARS2 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>