======= AATF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AATF
  * **<color #00a2e8>Official Name</color>**: apoptosis antagonizing transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26574|26574]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NY61|Q9NY61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AATF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AATF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608463|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of superoxide anion generation|
|negative regulation of amyloid precursor protein biosynthetic process|
|embryonic cleavage|
|leucine zipper domain binding|
|regulation of amyloid precursor protein biosynthetic process|
|negative regulation of glycoprotein biosynthetic process|
|negative regulation of glycoprotein metabolic process|
|regulation of superoxide anion generation|
|regulation of superoxide metabolic process|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|tau protein binding|
|negative regulation of reactive oxygen species metabolic process|
|regulation of reactive oxygen species metabolic process|
|ribosome biogenesis|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|cell division|
|regulation of mitotic cell cycle|
|cellular response to DNA damage stimulus|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cell adhesion|
|biological adhesion|
|embryo development|
|Golgi apparatus|
|negative regulation of cell death|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.44|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.32|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.26|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.19|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.08|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.9|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.84|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.79|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.77|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.75|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.7|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.73|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.75|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.76|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.78|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.79|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.86|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.89|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.92|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.96|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.03|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.63|
|[[:human genes:p:psmb4|PSMB4]]|0.578|
|[[:human genes:p:prim1|PRIM1]]|0.575|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.564|
|[[:human genes:t:tceb3c|TCEB3C]]|0.559|
|[[:human genes:t:tyms|TYMS]]|0.551|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.526|
|[[:human genes:c:chd4|CHD4]]|0.522|
|[[:human genes:i:ik|IK]]|0.519|
|[[:human genes:t:taf1|TAF1]]|0.519|
|[[:human genes:v:vps28|VPS28]]|0.518|
|[[:human genes:c:ccna2|CCNA2]]|0.517|
|[[:human genes:p:psma6|PSMA6]]|0.515|
|[[:human genes:r:rrp7a|RRP7A]]|0.511|
|[[:human genes:e:exosc8|EXOSC8]]|0.509|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.507|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.5|
|[[:human genes:s:supt5h|SUPT5H]]|0.498|
|[[:human genes:p:pole|POLE]]|0.493|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.493|
|[[:human genes:d:disp2|DISP2]]|0.488|
|[[:human genes:r:rps12|RPS12]]|0.486|
|[[:human genes:c:copg1|COPG1]]|0.485|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.485|
|[[:human genes:p:psmb2|PSMB2]]|0.484|
|[[:human genes:s:slc4a1|SLC4A1]]|0.483|
|[[:human genes:a:aqr|AQR]]|0.481|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.481|
|[[:human genes:o:orc1|ORC1]]|0.48|
|[[:human genes:p:pan2|PAN2]]|0.478|
|[[:human genes:p:psmc2|PSMC2]]|0.477|
|[[:human genes:r:rpl9|RPL9]]|0.475|
|[[:human genes:t:tspy8|TSPY8]]|0.475|
|[[:human genes:p:polr2d|POLR2D]]|0.472|
|[[:human genes:t:tfip11|TFIP11]]|0.472|
|[[:human genes:c:cbwd3|CBWD3]]|0.471|
|[[:human genes:h:hivep3|HIVEP3]]|0.471|
|[[:human genes:t:twistnb|TWISTNB]]|0.471|
|[[:human genes:w:wdr75|WDR75]]|0.469|
|[[:human genes:r:rpl35|RPL35]]|0.466|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.466|
|[[:human genes:c:cdc45|CDC45]]|0.465|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.463|
|[[:human genes:s:slc6a17|SLC6A17]]|0.463|
|[[:human genes:p:polr2a|POLR2A]]|0.461|
|[[:human genes:d:dhx38|DHX38]]|0.46|
|[[:human genes:s:sult1a4|SULT1A4]]|0.46|
|[[:human genes:s:sult1a3|SULT1A3]]|0.46|
|[[:human genes:t:ticrr|TICRR]]|0.458|
|[[:human genes:g:gid4|GID4]]|0.456|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.455|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.455|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.455|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.455|
|[[:human genes:p:psmb1|PSMB1]]|0.454|
|[[:human genes:d:dtl|DTL]]|0.454|
|[[:human genes:c:cbwd5|CBWD5]]|0.454|
|[[:human genes:p:polr1a|POLR1A]]|0.453|
|[[:human genes:n:narfl|NARFL]]|0.452|
|[[:human genes:n:nol12|NOL12]]|0.451|
|[[:human genes:r:rps2|RPS2]]|0.451|
|[[:human genes:a:akt1s1|AKT1S1]]|0.45|
|[[:human genes:u:utp3|UTP3]]|0.448|
|[[:human genes:p:psmd3|PSMD3]]|0.447|
|[[:human genes:c:cactin|CACTIN]]|0.447|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.445|
|[[:human genes:r:rps19|RPS19]]|0.445|
|[[:human genes:u:upf1|UPF1]]|0.444|
|[[:human genes:m:med14|MED14]]|0.444|
|[[:human genes:r:rpl6|RPL6]]|0.443|
|[[:human genes:g:gar1|GAR1]]|0.443|
|[[:human genes:r:rps7|RPS7]]|0.443|
|[[:human genes:o:ogfr|OGFR]]|0.442|
|[[:human genes:o:osbp|OSBP]]|0.442|
|[[:human genes:s:smtn|SMTN]]|0.441|
|[[:human genes:n:npipb5|NPIPB5]]|0.44|
|[[:human genes:n:nfatc4|NFATC4]]|0.438|
|[[:human genes:c:cbwd6|CBWD6]]|0.438|
|[[:human genes:d:ddtl|DDTL]]|0.438|
|[[:human genes:o:orc6|ORC6]]|0.437|
|[[:human genes:p:pigs|PIGS]]|0.437|
|[[:human genes:s:smg1|SMG1]]|0.433|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.433|
|[[:human genes:a:ankle1|ANKLE1]]|0.432|
|[[:human genes:s:slc38a7|SLC38A7]]|0.432|
|[[:human genes:c:ctage4|CTAGE4]]|0.432|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.432|
|[[:human genes:s:snip1|SNIP1]]|0.43|
|[[:human genes:v:vps54|VPS54]]|0.43|
|[[:human genes:c:col2a1|COL2A1]]|0.429|
|[[:human genes:k:krt78|KRT78]]|0.429|
|[[:human genes:c:chchd3|CHCHD3]]|0.428|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.427|
|[[:human genes:u:utp20|UTP20]]|0.426|
|[[:human genes:s:supt6h|SUPT6H]]|0.425|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.425|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.425|
|[[:human genes:t:trappc8|TRAPPC8]]|0.425|
|[[:human genes:r:rad51|RAD51]]|0.424|
|[[:human genes:r:riok2|RIOK2]]|0.424|
|[[:human genes:r:rrn3|RRN3]]|0.424|
|[[:human genes:d:ddx56|DDX56]]|0.422|
|[[:human genes:r:ranbp2|RANBP2]]|0.422|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.421|
|[[:human genes:m:mtch2|MTCH2]]|0.421|
|[[:human genes:p:psma3|PSMA3]]|0.42|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.42|
|[[:human genes:c:copa|COPA]]|0.42|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.419|
|[[:human genes:g:golga6b|GOLGA6B]]|0.419|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.419|
|[[:human genes:p:psma7|PSMA7]]|0.417|
|[[:human genes:r:rpl30|RPL30]]|0.416|
|[[:human genes:r:rnpc3|RNPC3]]|0.415|
|[[:human genes:c:cep192|CEP192]]|0.414|
|[[:human genes:f:fam25b|FAM25B]]|0.414|
|[[:human genes:c:copz1|COPZ1]]|0.414|
|[[:human genes:p:psmd11|PSMD11]]|0.414|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.413|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.413|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.412|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.412|
|[[:human genes:f:fam160a1|FAM160A1]]|0.412|
|[[:human genes:c:chaf1a|CHAF1A]]|0.411|
|[[:human genes:c:chmp4b|CHMP4B]]|0.411|
|[[:human genes:c:copb1|COPB1]]|0.411|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.411|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.411|
|[[:human genes:m:myb|MYB]]|0.41|
|[[:human genes:c:cdca3|CDCA3]]|0.409|
|[[:human genes:l:lrr1|LRR1]]|0.409|
|[[:human genes:n:nup160|NUP160]]|0.407|
|[[:human genes:t:tspy2|TSPY2]]|0.407|
|[[:human genes:t:timeless|TIMELESS]]|0.407|
|[[:human genes:n:nol10|NOL10]]|0.407|
|[[:human genes:s:sult2b1|SULT2B1]]|0.406|
|[[:human genes:n:noc4l|NOC4L]]|0.405|
|[[:human genes:t:ttc1|TTC1]]|0.405|
|[[:human genes:x:xab2|XAB2]]|0.405|
|[[:human genes:g:golga6a|GOLGA6A]]|0.404|
|[[:human genes:p:psmc1|PSMC1]]|0.404|
|[[:human genes:z:znf830|ZNF830]]|0.404|
|[[:human genes:g:gon4l|GON4L]]|0.404|
|[[:human genes:r:rplp0|RPLP0]]|0.404|
|[[:human genes:s:syt9|SYT9]]|0.404|
|[[:human genes:g:gbf1|GBF1]]|0.403|
|[[:human genes:c:cln6|CLN6]]|0.403|
|[[:human genes:t:tspy1|TSPY1]]|0.403|
|[[:human genes:t:trappc11|TRAPPC11]]|0.403|
|[[:human genes:s:sap30bp|SAP30BP]]|0.401|
|[[:human genes:s:s1pr4|S1PR4]]|0.401|
|[[:human genes:n:nupl1|NUPL1]]|0.401|
|[[:human genes:a:aamp|AAMP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 999
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AATF Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>