======= ABCA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCA1
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=19|19]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95477|O95477]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.  ABC proteins transport various molecules across extra- and intracellular membranes.  ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).  This protein is a member of the ABC1 subfamily.  Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes.  With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway.  Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC tran|
|ABC2 membrane 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of high-density lipoprotein particle assembly|
|phosphatidylserine floppase activity|
|regulation of high-density lipoprotein particle assembly|
|apolipoprotein A-I receptor activity|
|phosphatidylcholine floppase activity|
|anion transmembrane transporter activity|
|apolipoprotein A-I-mediated signaling pathway|
|apolipoprotein A-I binding|
|regulation of Cdc42 protein signal transduction|
|negative regulation of cholesterol storage|
|platelet dense granule organization|
|interleukin-1 beta secretion|
|high-density lipoprotein particle binding|
|phospholipid homeostasis|
|interleukin-1 secretion|
|phospholipid efflux|
|negative regulation of macrophage derived foam cell differentiation|
|high-density lipoprotein particle assembly|
|response to laminar fluid shear stress|
|interleukin-1 beta production|
|regulation of cholesterol storage|
|apolipoprotein binding|
|phospholipid transporter activity|
|reverse cholesterol transport|
|interleukin-1 production|
|intracellular cholesterol transport|
|positive regulation of cholesterol efflux|
|cellular response to cholesterol|
|intracellular sterol transport|
|cholesterol transfer activity|
|cellular response to low-density lipoprotein particle stimulus|
|negative regulation of lipid storage|
|cellular response to sterol|
|small GTPase binding|
|cholesterol efflux|
|regulation of cholesterol efflux|
|positive regulation of cholesterol transport|
|positive regulation of sterol transport|
|plasma lipoprotein particle assembly|
|response to cholesterol|
|response to lipoprotein particle|
|cellular response to lipoprotein particle stimulus|
|regulation of macrophage derived foam cell differentiation|
|protein-lipid complex assembly|
|response to sterol|
|lipid transporter activity|
|response to fluid shear stress|
|secretory granule organization|
|intracellular lipid transport|
|negative regulation of lipid localization|
|phospholipid translocation|
|plasma lipoprotein particle organization|
|lipid translocation|
|regulation of lipid storage|
|regulation of cholesterol transport|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|cytokine secretion|
|cholesterol binding|
|regulation of membrane lipid distribution|
|ATPase-coupled transmembrane transporter activity|
|cholesterol transport|
|syntaxin binding|
|anion homeostasis|
|endocytic vesicle|
|lytic vacuole organization|
|lysosome organization|
|phagocytic vesicle|
|positive regulation of lipid transport|
|sterol transport|
|cellular response to retinoic acid|
|regulation of plasma lipoprotein particle levels|
|cholesterol homeostasis|
|ATPase binding|
|sterol homeostasis|
|positive regulation of lipid localization|
|cellular response to alcohol|
|protein lipidation|
|lipoprotein biosynthetic process|
|phospholipid transport|
|phospholipid binding|
|regulation of lipid transport|
|response to retinoic acid|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|organophosphate ester transport|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|secondary alcohol metabolic process|
|phagocytosis, engulfment|
|vacuole organization|
|lipid homeostasis|
|sterol metabolic process|
|regulation of lipid localization|
|organic hydroxy compound transport|
|plasma membrane invagination|
|regulation of Rho protein signal transduction|
|membrane invagination|
|cAMP-mediated signaling|
|cytokine production|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|cellular response to acid chemical|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|response to nutrient|
|cellular response to biotic stimulus|
|membrane raft|
|endosomal transport|
|response to alcohol|
|ATPase activity|
|regulation of Ras protein signal transduction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of protein complex assembly|
|steroid metabolic process|
|endosome|
|anion transmembrane transport|
|lipid transport|
|vesicle organization|
|response to lipopolysaccharide|
|alcohol metabolic process|
|lipid localization|
|response to molecule of bacterial origin|
|phagocytosis|
|signaling receptor binding|
|second-messenger-mediated signaling|
|regulation of small GTPase mediated signal transduction|
|response to acid chemical|
|extracellular structure organization|
|external side of plasma membrane|
|regulation of lipid metabolic process|
|endomembrane system organization|
|regulation of protein complex assembly|
|organic hydroxy compound metabolic process|
|organic anion transport|
|response to nutrient levels|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|endocytosis|
|anion transport|
|import into cell|
|intracellular membrane-bounded organelle|
|response to bacterium|
|perinuclear region of cytoplasm|
|negative regulation of cell differentiation|
|ion homeostasis|
|response to lipid|
|membrane organization|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|secretion|
|positive regulation of cellular component organization|
|lipid metabolic process|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|ion transport|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|1.73|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.73|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.74|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.76|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.77|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.79|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.79|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.8|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.8|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.81|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15314
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCA1 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>