======= ABCF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCF1
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily F member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23|23]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NE71|Q8NE71]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603429|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 2 is required for efficient Cap- and IRES- mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation factor activity, RNA binding|
|ribosome|
|nuclear envelope|
|ATPase activity|
|translation|
|peptide biosynthetic process|
|inflammatory response|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|transmembrane transport|
|defense response|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.83|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.7|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.71|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.73|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.74|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.75|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.84|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.9|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.9|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.95|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.99|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.03|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.05|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.07|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.29|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.55|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.472|
|[[:human genes:g:gtf3a|GTF3A]]|0.464|
|[[:human genes:e:eif4e|EIF4E]]|0.452|
|[[:human genes:a:apaf1|APAF1]]|0.447|
|[[:human genes:r:rnmt|RNMT]]|0.435|
|[[:human genes:c:casp9|CASP9]]|0.435|
|[[:human genes:e:eif3f|EIF3F]]|0.435|
|[[:human genes:h:hspd1|HSPD1]]|0.435|
|[[:human genes:h:hccs|HCCS]]|0.435|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.428|
|[[:human genes:p:pelo|PELO]]|0.424|
|[[:human genes:m:mars|MARS]]|0.422|
|[[:human genes:t:tgs1|TGS1]]|0.42|
|[[:human genes:t:thg1l|THG1L]]|0.416|
|[[:human genes:r:rptor|RPTOR]]|0.415|
|[[:human genes:t:txnrd1|TXNRD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 243/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|7/28|
|bone|8/26|
|breast|8/33|
|central nervous system|15/56|
|cervix|1/4|
|colorectal|8/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|10/21|
|liver|7/20|
|lung|25/75|
|lymphocyte|6/16|
|ovary|9/26|
|pancreas|13/24|
|peripheral nervous system|2/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1354
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCF1 Expression in NALM6 Cells: 7.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>