======= ABHD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABHD2
  * **<color #00a2e8>Official Name</color>**: abhydrolase domain containing 2, acylglycerol lipase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11057|11057]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08910|P08910]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABHD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABHD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612196|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity). {ECO:0000250|UniProtKB:Q9QXM0, ECO:0000269|PubMed:26989199}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 1|
|Abhydrolase 6|
|Abhydrolase 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetylesterase activity|
|hormone-sensitive lipase activity|
|short-chain carboxylesterase activity|
|sperm plasma membrane|
|medium-chain fatty acid catabolic process|
|medium-chain fatty acid biosynthetic process|
|acylglycerol lipase activity|
|medium-chain fatty acid metabolic process|
|hormone binding|
|lipase activity|
|acrosome reaction|
|sperm capacitation|
|acylglycerol catabolic process|
|neutral lipid catabolic process|
|sperm flagellum|
|response to progesterone|
|steroid hormone receptor activity|
|glycerolipid catabolic process|
|acrosomal vesicle|
|fatty acid catabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|monocarboxylic acid catabolic process|
|fatty acid biosynthetic process|
|steroid hormone mediated signaling pathway|
|single fertilization|
|spermatid development|
|spermatid differentiation|
|cell maturation|
|hormone-mediated signaling pathway|
|fertilization|
|monocarboxylic acid biosynthetic process|
|cellular response to steroid hormone stimulus|
|response to ketone|
|cellular lipid catabolic process|
|developmental maturation|
|germ cell development|
|negative regulation of cell migration|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|negative regulation of cell motility|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|negative regulation of cellular component movement|
|fatty acid metabolic process|
|negative regulation of locomotion|
|response to steroid hormone|
|cellular process involved in reproduction in multicellular organism|
|glycerolipid metabolic process|
|small molecule catabolic process|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|cellular response to organic cyclic compound|
|spermatogenesis|
|male gamete generation|
|response to wounding|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cell motility|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cell development|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4250
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABHD2 Expression in NALM6 Cells: 7.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>