======= ABHD8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABHD8
  * **<color #00a2e8>Official Name</color>**: abhydrolase domain containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79575|79575]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96I13|Q96I13]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABHD8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABHD8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621036|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 6|
|Abhydrolase 5|
|Hydrolase 4|
|Abhydrolase 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|carboxylic ester hydrolase activity|
|lipid homeostasis|
|chemical homeostasis|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.478|
|[[:human genes:s:slc4a1|SLC4A1]]|0.477|
|[[:human genes:c:c14orf93|C14orf93]]|0.466|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.459|
|[[:human genes:r:rps5|RPS5]]|0.45|
|[[:human genes:c:cope|COPE]]|0.45|
|[[:human genes:p:polr2j3|POLR2J3]]|0.444|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.443|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.431|
|[[:human genes:t:tceb3c|TCEB3C]]|0.428|
|[[:human genes:c:col2a1|COL2A1]]|0.426|
|[[:human genes:p:paf1|PAF1]]|0.426|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.425|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.419|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.417|
|[[:human genes:r:rrp1|RRP1]]|0.417|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.415|
|[[:human genes:c:cdh24|CDH24]]|0.411|
|[[:human genes:a:aamp|AAMP]]|0.411|
|[[:human genes:r:rrn3|RRN3]]|0.41|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.408|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.408|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2743
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABHD8 Expression in NALM6 Cells: 2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>