======= ACACB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACACB
  * **<color #00a2e8>Official Name</color>**: acetyl-CoA carboxylase beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=32|32]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00763|O00763]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACACB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACACB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601557|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis.  ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria.  ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis.  There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:20952656}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Biotin carb C|
|Biotin lipoyl|
|ACC central|
|CPSase L D2|
|CPSase L chain|
|Carboxyl trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetyl-CoA carboxylase activity|
|malonyl-CoA biosynthetic process|
|biotin carboxylase activity|
|malonyl-CoA metabolic process|
|negative regulation of fatty acid beta-oxidation|
|biotin binding|
|negative regulation of fatty acid oxidation|
|carnitine shuttle|
|fatty acid transmembrane transport|
|regulation of fatty acid beta-oxidation|
|positive regulation of lipid storage|
|negative regulation of lipid catabolic process|
|negative regulation of fatty acid metabolic process|
|acetyl-CoA metabolic process|
|regulation of fatty acid oxidation|
|energy homeostasis|
|intracellular lipid transport|
|positive regulation of heart growth|
|regulation of cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|acyl-CoA biosynthetic process|
|thioester biosynthetic process|
|regulation of lipid storage|
|positive regulation of organ growth|
|regulation of lipid catabolic process|
|regulation of cholesterol metabolic process|
|long-chain fatty acid transport|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|regulation of heart growth|
|fatty acid transport|
|regulation of alcohol biosynthetic process|
|endomembrane system|
|positive regulation of lipid localization|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|regulation of steroid biosynthetic process|
|negative regulation of small molecule metabolic process|
|mitochondrial transmembrane transport|
|protein homotetramerization|
|regulation of organ growth|
|thioester metabolic process|
|acyl-CoA metabolic process|
|regulation of glucose metabolic process|
|regulation of steroid metabolic process|
|fatty acid biosynthetic process|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|monocarboxylic acid transport|
|regulation of lipid localization|
|regulation of cellular carbohydrate metabolic process|
|purine ribonucleotide biosynthetic process|
|protein tetramerization|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|mitochondrial outer membrane|
|ribose phosphate biosynthetic process|
|positive regulation of developmental growth|
|purine-containing compound biosynthetic process|
|regulation of cellular ketone metabolic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|regulation of lipid biosynthetic process|
|regulation of carbohydrate metabolic process|
|cofactor biosynthetic process|
|mitochondrial transport|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|negative regulation of cellular catabolic process|
|positive regulation of growth|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|negative regulation of catabolic process|
|purine ribonucleotide metabolic process|
|lipid localization|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|ribonucleotide metabolic process|
|regulation of developmental growth|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein homooligomerization|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|response to nutrient levels|
|protein complex oligomerization|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|regulation of growth|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|ion transmembrane transport|
|cellular lipid metabolic process|
|regulation of catabolic process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|mitochondrion|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|ion transport|
|organonitrogen compound biosynthetic process|
|ATP binding|
|intracellular transport|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10664
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACACB Expression in NALM6 Cells: 4.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>