======= ACAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACAT1
  * **<color #00a2e8>Official Name</color>**: acetyl-CoA acetyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=38|38]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24752|P24752]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607809|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a major role in ketone body metabolism.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thiolase C|
|Thiolase N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proximal convoluted tubule development|
|propionyl-CoA biosynthetic process|
|C-acetyltransferase activity|
|metanephric proximal convoluted tubule development|
|propionyl-CoA metabolic process|
|isoleucine metabolic process|
|metanephric proximal tubule development|
|acetyl-CoA catabolic process|
|isoleucine catabolic process|
|ketone body catabolic process|
|acetyl-CoA C-acetyltransferase activity|
|steroid esterification|
|sterol esterification|
|cholesterol esterification|
|proximal tubule development|
|acetyl-CoA C-acyltransferase activity|
|ribonucleoside bisphosphate catabolic process|
|purine nucleoside bisphosphate catabolic process|
|nucleoside bisphosphate catabolic process|
|ketone body biosynthetic process|
|coenzyme A biosynthetic process|
|coenzyme binding|
|cellular ketone body metabolic process|
|fatty acid derivative catabolic process|
|ketone body metabolic process|
|acetyl-CoA biosynthetic process|
|metanephric nephron tubule development|
|coenzyme A metabolic process|
|coenzyme catabolic process|
|metanephric nephron epithelium development|
|metanephric tubule development|
|metanephric epithelium development|
|branched-chain amino acid catabolic process|
|branched-chain amino acid metabolic process|
|acetyl-CoA metabolic process|
|fatty-acyl-CoA biosynthetic process|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|adipose tissue development|
|fatty-acyl-CoA metabolic process|
|purine nucleotide catabolic process|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|purine-containing compound catabolic process|
|sulfur compound catabolic process|
|fatty acid beta-oxidation|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|cofactor catabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|nephron tubule development|
|fatty acid oxidation|
|lipid oxidation|
|renal tubule development|
|metanephros development|
|fatty acid derivative biosynthetic process|
|fatty acid catabolic process|
|thioester metabolic process|
|nephron epithelium development|
|acyl-CoA metabolic process|
|alpha-amino acid catabolic process|
|nucleobase-containing small molecule biosynthetic process|
|monocarboxylic acid catabolic process|
|nephron development|
|cellular amino acid catabolic process|
|liver development|
|organophosphate catabolic process|
|kidney epithelium development|
|hepaticobiliary system development|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|drug catabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|carbohydrate derivative catabolic process|
|response to starvation|
|cellular lipid catabolic process|
|lipid modification|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|connective tissue development|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|steroid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|kidney development|
|renal system development|
|lipid catabolic process|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|urogenital system development|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein homooligomerization|
|enzyme binding|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|nucleobase-containing compound catabolic process|
|gland development|
|generation of precursor metabolites and energy|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|response to nutrient levels|
|drug metabolic process|
|protein complex oligomerization|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|brain development|
|head development|
|cellular amide metabolic process|
|tube development|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|oxidation-reduction process|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.95|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.88|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.87|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.86|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.82|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:madcam1|MADCAM1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18367
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACAT1 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>