======= ACE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACE2
  * **<color #00a2e8>Official Name</color>**: angiotensin I converting enzyme 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59272|59272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYF1|Q9BYF1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300335|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:24227843}. (Microbial infection) Acts as a receptor for Human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:15897467}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|angiotensin-mediated drinking behavior|
|brain renin-angiotensin system|
|peptidyl-dipeptidase activity|
|positive regulation of gap junction assembly|
|regulation of gap junction assembly|
|tryptophan transport|
|receptor biosynthetic process|
|exopeptidase activity|
|receptor-mediated virion attachment to host cell|
|regulation of blood volume by renin-angiotensin|
|virion attachment to host cell|
|aromatic amino acid transport|
|drinking behavior|
|adhesion of symbiont to host cell|
|nervous system process involved in regulation of systemic arterial blood pressure|
|regulation of angiotensin levels in blood|
|positive regulation of cardiac muscle contraction|
|angiotensin maturation|
|adhesion of symbiont to host|
|positive regulation of striated muscle contraction|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|carboxypeptidase activity|
|positive regulation of amino acid transport|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|metallocarboxypeptidase activity|
|regulation of amino acid transport|
|positive regulation of cell junction assembly|
|peptide hormone processing|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of heart contraction|
|positive regulation of muscle contraction|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|positive regulation of anion transport|
|brush border membrane|
|regulation of vasoconstriction|
|regulation of organic acid transport|
|metallopeptidase activity|
|regulation of cardiac conduction|
|positive regulation of blood circulation|
|endopeptidase activity|
|virus receptor activity|
|regulation of cardiac muscle contraction|
|feeding behavior|
|regulation of cell junction assembly|
|regulation of striated muscle contraction|
|regulation of systemic arterial blood pressure|
|regulation of amine transport|
|viral entry into host cell|
|regulation of anion transport|
|positive regulation of reactive oxygen species metabolic process|
|entry into host|
|entry into host cell|
|receptor metabolic process|
|amino acid transport|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|interaction with host|
|protein processing|
|regulation of muscle contraction|
|vascular process in circulatory system|
|regulation of reactive oxygen species metabolic process|
|regulation of blood pressure|
|viral life cycle|
|hormone metabolic process|
|protein maturation|
|membrane raft|
|regulation of muscle system process|
|regulation of heart contraction|
|positive regulation of ion transport|
|regulation of blood circulation|
|organic acid transport|
|carboxylic acid transport|
|regulation of inflammatory response|
|blood circulation|
|circulatory system process|
|organic anion transport|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|peptide metabolic process|
|regulation of hormone levels|
|behavior|
|anion transport|
|regulation of system process|
|cell surface|
|regulation of cytokine production|
|regulation of ion transport|
|viral process|
|regulation of defense response|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cation transport|
|zinc ion binding|
|biological adhesion|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|regulation of response to external stimulus|
|positive regulation of cellular component organization|
|proteolysis|
|ion transport|
|nervous system process|
|regulation of response to stress|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|nitrogen compound transport|
|regulation of transport|
|extracellular region|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.75|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.92|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACE2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>