======= ACER2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACER2
  * **<color #00a2e8>Official Name</color>**: alkaline ceramidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340485|340485]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5QJU3|Q5QJU3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACER2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACER2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613492|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:18945876, ECO:0000269|PubMed:20089856}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ceramidase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein glycosylation in Golgi|
|dihydroceramidase activity|
|regulation of protein glycosylation in Golgi|
|negative regulation of protein glycosylation|
|ceramidase activity|
|N-acylsphingosine amidohydrolase activity|
|negative regulation of cell adhesion mediated by integrin|
|sphingosine biosynthetic process|
|sphingoid biosynthetic process|
|sphingosine metabolic process|
|negative regulation of glycoprotein biosynthetic process|
|regulation of protein glycosylation|
|sphingoid metabolic process|
|negative regulation of glycoprotein metabolic process|
|diol biosynthetic process|
|ceramide catabolic process|
|diol metabolic process|
|sphingolipid catabolic process|
|membrane lipid catabolic process|
|negative regulation of cell-matrix adhesion|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|regulation of cell adhesion mediated by integrin|
|polyol biosynthetic process|
|negative regulation of cell-substrate adhesion|
|integral component of Golgi membrane|
|DNA damage response, signal transduction by p53 class mediator|
|ceramide metabolic process|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|sphingolipid biosynthetic process|
|signal transduction in response to DNA damage|
|response to retinoic acid|
|polyol metabolic process|
|alcohol biosynthetic process|
|regulation of cell-matrix adhesion|
|signal transduction by p53 class mediator|
|membrane lipid biosynthetic process|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|sphingolipid metabolic process|
|positive regulation of endopeptidase activity|
|organic hydroxy compound biosynthetic process|
|positive regulation of peptidase activity|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|regulation of cell-substrate adhesion|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of cell adhesion|
|lipid catabolic process|
|alcohol metabolic process|
|regulation of autophagy|
|response to acid chemical|
|positive regulation of proteolysis|
|cellular response to drug|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|organic hydroxy compound metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|negative regulation of protein modification process|
|Golgi membrane|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of cell adhesion|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|response to lipid|
|positive regulation of cell population proliferation|
|cellular lipid metabolic process|
|Golgi apparatus|
|regulation of catabolic process|
|response to drug|
|negative regulation of cellular protein metabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|lipid metabolic process|
|regulation of hydrolase activity|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15912
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.94 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACER2 Expression in NALM6 Cells: 0.94'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>