======= ACIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACIN1
  * **<color #00a2e8>Official Name</color>**: apoptotic chromatin condensation inducer 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22985|22985]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKV3|Q9UKV3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604562|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence- independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ASAP complex|
|apoptotic chromosome condensation|
|positive regulation of monocyte differentiation|
|regulation of monocyte differentiation|
|apoptotic nuclear changes|
|cellular component disassembly involved in execution phase of apoptosis|
|chromosome condensation|
|execution phase of apoptosis|
|positive regulation of myeloid leukocyte differentiation|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|positive regulation of myeloid cell differentiation|
|myeloid cell homeostasis|
|regulation of myeloid leukocyte differentiation|
|positive regulation of leukocyte differentiation|
|DNA packaging|
|positive regulation of hemopoiesis|
|nucleic acid binding|
|homeostasis of number of cells|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|ATPase activity|
|regulation of leukocyte differentiation|
|DNA conformation change|
|enzyme binding|
|RNA splicing|
|cellular component disassembly|
|nuclear speck|
|regulation of hemopoiesis|
|mRNA processing|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|apoptotic process|
|positive regulation of cell differentiation|
|programmed cell death|
|chromosome organization|
|cell death|
|positive regulation of immune system process|
|positive regulation of developmental process|
|RNA binding|
|homeostatic process|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.37|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.35|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.16|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.1|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.06|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.05|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.95|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.83|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.73|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.09|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 142/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|1/28|
|blood|8/28|
|bone|9/26|
|breast|7/33|
|central nervous system|15/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|5/21|
|liver|5/20|
|lung|14/75|
|lymphocyte|4/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1692
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACIN1 Expression in NALM6 Cells: 8.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>