======= ACSL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACSL3
  * **<color #00a2e8>Official Name</color>**: acyl-CoA synthetase long chain family member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2181|2181]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95573|O95573]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACSL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACSL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602371|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). {ECO:0000250, ECO:0000269|PubMed:18003621}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AMP-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of phosphatidylcholine biosynthetic process|
|positive regulation of Golgi to plasma membrane protein transport|
|regulation of phosphatidylcholine biosynthetic process|
|decanoate-CoA ligase activity|
|regulation of Golgi to plasma membrane protein transport|
|lipid import into cell|
|long-chain fatty acid import into cell|
|very-low-density lipoprotein particle assembly|
|positive regulation of phospholipid biosynthetic process|
|long-chain fatty acid-CoA ligase activity|
|acyl-CoA ligase activity|
|regulation of phospholipid biosynthetic process|
|long-chain fatty-acyl-CoA biosynthetic process|
|long-chain fatty-acyl-CoA metabolic process|
|plasma lipoprotein particle assembly|
|protein-lipid complex assembly|
|fatty-acyl-CoA biosynthetic process|
|fatty-acyl-CoA metabolic process|
|plasma lipoprotein particle organization|
|acyl-CoA biosynthetic process|
|thioester biosynthetic process|
|positive regulation of phospholipid metabolic process|
|protein-lipid complex subunit organization|
|positive regulation of protein localization to plasma membrane|
|peroxisomal membrane|
|long-chain fatty acid transport|
|purine nucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|positive regulation of protein localization to cell periphery|
|regulation of plasma lipoprotein particle levels|
|fatty acid transport|
|positive regulation of lipid biosynthetic process|
|lipid droplet|
|regulation of phospholipid metabolic process|
|fatty acid derivative biosynthetic process|
|regulation of protein localization to plasma membrane|
|acyl-CoA metabolic process|
|thioester metabolic process|
|regulation of protein localization to cell periphery|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|positive regulation of protein localization to membrane|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|monocarboxylic acid transport|
|coenzyme biosynthetic process|
|positive regulation of lipid metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|mitochondrial outer membrane|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|regulation of lipid biosynthetic process|
|regulation of protein localization to membrane|
|cofactor biosynthetic process|
|response to nutrient|
|protein domain specific binding|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|purine ribonucleotide metabolic process|
|lipid localization|
|fatty acid metabolic process|
|positive regulation of cellular protein localization|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|extracellular structure organization|
|regulation of lipid metabolic process|
|positive regulation of protein transport|
|positive regulation of secretion|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|response to nutrient levels|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|regulation of vesicle-mediated transport|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|import into cell|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|head development|
|cellular amide metabolic process|
|regulation of secretion|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|ATP binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-4.54|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-3.26|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-2.49|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-2.15|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2.04|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.04|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.85|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.84|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.84|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.83|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.8|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.72|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.81|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.81|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.84|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.86|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.88|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.97|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.01|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.05|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.06|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.06|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.13|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.13|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.17|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.3|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.33|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.72|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.83|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|3.14|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|3.18|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.41|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|3.64|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|3.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c7orf26|C7orf26]]|0.42|
|[[:human genes:a:acaa1|ACAA1]]|0.407|
|[[:human genes:a:asun|ASUN]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 58/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|4/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|2/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACSL3 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>