======= ACTL6A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTL6A
  * **<color #00a2e8>Official Name</color>**: actin like 6A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=86|86]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O96019|O96019]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTL6A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTL6A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604958|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|npBAF complex|
|Ino80 complex|
|histone H2A acetylation|
|NuA4 histone acetyltransferase complex|
|SWI/SNF complex|
|blastocyst formation|
|nucleosomal DNA binding|
|histone H4 acetylation|
|neural retina development|
|ATP-dependent chromatin remodeling|
|blastocyst development|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|spinal cord development|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|retina development in camera-type eye|
|protein acetylation|
|chromatin remodeling|
|protein acylation|
|DNA recombination|
|nuclear chromatin|
|protein deubiquitination|
|transcription coactivator activity|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|camera-type eye development|
|eye development|
|visual system development|
|histone modification|
|sensory system development|
|covalent chromatin modification|
|in utero embryonic development|
|chromatin binding|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA repair|
|sensory organ development|
|protein-containing complex|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of growth|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|proteolysis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.24|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.13|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.01|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.91|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.82|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.76|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.73|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.7|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.81|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.9|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 708/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|20/21|
|liver|20/20|
|lung|69/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|11/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 593
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTL6A Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>