======= ACTN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTN1
  * **<color #00a2e8>Official Name</color>**: actinin alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=87|87]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12814|P12814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102575|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAMSAP CH|
|CH|
|efhand Ca insen|
|Spectrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of postsynapse|
|actin filament network formation|
|actin crosslink formation|
|fascia adherens|
|vinculin binding|
|pseudopodium|
|platelet formation|
|platelet morphogenesis|
|cell-substrate adherens junction assembly|
|focal adhesion assembly|
|adherens junction assembly|
|cell-substrate junction assembly|
|platelet aggregation|
|brush border|
|homotypic cell-cell adhesion|
|actin filament bundle assembly|
|nuclear receptor transcription coactivator activity|
|actin filament bundle organization|
|platelet alpha granule lumen|
|stress fiber|
|double-stranded RNA binding|
|actin filament|
|adherens junction organization|
|postsynapse organization|
|ruffle|
|cell projection|
|ion channel binding|
|cell-matrix adhesion|
|platelet degranulation|
|integrin binding|
|Z disc|
|platelet activation|
|cell junction assembly|
|cell-cell junction|
|cell-substrate adhesion|
|actin filament binding|
|cell junction organization|
|myeloid cell differentiation|
|actin filament organization|
|synapse organization|
|blood coagulation|
|coagulation|
|hemostasis|
|negative regulation of cellular component movement|
|glutamatergic synapse|
|focal adhesion|
|supramolecular fiber organization|
|wound healing|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|cell-cell adhesion|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|response to wounding|
|hematopoietic or lymphoid organ development|
|immune system development|
|regulated exocytosis|
|calcium ion binding|
|cell morphogenesis|
|exocytosis|
|cellular component morphogenesis|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|cell activation|
|cytoskeleton organization|
|secretion|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3918
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTN1 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>