======= ACTN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTN2
  * **<color #00a2e8>Official Name</color>**: actinin alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=88|88]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35609|P35609]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102573|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
|CAMSAP CH|
|efhand Ca insen|
|Spectrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|titin Z domain binding|
|phospholipase C-activating angiotensin-activated signaling pathway|
|actin filament uncapping|
|thyroid hormone receptor coactivator activity|
|microspike assembly|
|FATZ binding|
|positive regulation of endocytic recycling|
|LIM domain binding|
|angiotensin-activated signaling pathway|
|regulation of endocytic recycling|
|negative regulation of protein localization to cell surface|
|positive regulation of actin filament depolymerization|
|titin binding|
|pseudopodium|
|postsynaptic density, intracellular component|
|negative regulation of potassium ion transmembrane transporter activity|
|positive regulation of protein depolymerization|
|cellular response to angiotensin|
|postsynaptic density membrane|
|positive regulation of potassium ion transmembrane transporter activity|
|negative regulation of potassium ion transmembrane transport|
|response to angiotensin|
|cell-substrate adherens junction assembly|
|focal adhesion assembly|
|negative regulation of potassium ion transport|
|adherens junction assembly|
|regulation of NMDA receptor activity|
|positive regulation of protein complex disassembly|
|muscle filament sliding|
|positive regulation of potassium ion transmembrane transport|
|actin-myosin filament sliding|
|regulation of protein localization to cell surface|
|cell-substrate junction assembly|
|positive regulation of potassium ion transport|
|structural constituent of muscle|
|sarcomere organization|
|regulation of actin filament depolymerization|
|cortical actin cytoskeleton|
|regulation of potassium ion transmembrane transporter activity|
|cardiac muscle cell development|
|regulation of glutamate receptor signaling pathway|
|cardiac cell development|
|myofibril assembly|
|platelet alpha granule lumen|
|positive regulation of cation channel activity|
|negative regulation of ion transmembrane transporter activity|
|filopodium|
|regulation of neurotransmitter receptor activity|
|cytoskeletal protein binding|
|phosphatidylinositol-4,5-bisphosphate binding|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|actin filament|
|negative regulation of cation transmembrane transport|
|adherens junction organization|
|regulation of protein depolymerization|
|cardiac muscle cell differentiation|
|actin-mediated cell contraction|
|protein homotetramerization|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of ion transmembrane transporter activity|
|cellular component assembly involved in morphogenesis|
|actin filament-based movement|
|positive regulation of transporter activity|
|negative regulation of cellular protein localization|
|regulation of protein complex disassembly|
|actomyosin structure organization|
|cardiocyte differentiation|
|negative regulation of transmembrane transport|
|ion channel binding|
|cell-matrix adhesion|
|platelet degranulation|
|integrin binding|
|Z disc|
|striated muscle cell development|
|positive regulation of cation transmembrane transport|
|negative regulation of ion transport|
|dendritic spine|
|muscle cell development|
|protein tetramerization|
|positive regulation of ion transmembrane transport|
|protein dimerization activity|
|cardiac muscle tissue development|
|cell junction assembly|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of actin polymerization or depolymerization|
|protein localization to plasma membrane|
|regulation of actin filament length|
|cell-substrate adhesion|
|positive regulation of supramolecular fiber organization|
|striated muscle cell differentiation|
|positive regulation of transmembrane transport|
|actin filament binding|
|positive regulation of intracellular transport|
|cell junction organization|
|positive regulation of cytoskeleton organization|
|protein localization to cell periphery|
|protein domain specific binding|
|muscle cell differentiation|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of actin filament organization|
|regulation of transmembrane transporter activity|
|cellular response to peptide hormone stimulus|
|positive regulation of ion transport|
|regulation of transporter activity|
|striated muscle tissue development|
|muscle tissue development|
|muscle system process|
|cellular response to peptide|
|regulation of cation transmembrane transport|
|protein homooligomerization|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|cytoskeleton|
|MAPK cascade|
|regulation of cellular component size|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|response to peptide hormone|
|signal transduction by protein phosphorylation|
|focal adhesion|
|regulation of membrane potential|
|plasma membrane bounded cell projection assembly|
|supramolecular fiber organization|
|cell projection assembly|
|response to peptide|
|muscle structure development|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|negative regulation of transport|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|protein complex oligomerization|
|heart development|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|actin filament-based process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|cellular response to nitrogen compound|
|regulation of ion transport|
|regulated exocytosis|
|calcium ion binding|
|organelle assembly|
|exocytosis|
|cellular component morphogenesis|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|protein phosphorylation|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cytoskeleton organization|
|secretion|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|phosphorylation|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.09|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.83|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.92|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13365
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTN2 Expression in NALM6 Cells: -1.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>