======= ADAT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAT2
  * **<color #00a2e8>Official Name</color>**: adenosine deaminase tRNA specific 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=134637|134637]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6V5|Q7Z6V5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615388|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probably participates in deamination of adenosine-34 to inosine in many tRNAs. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dCMP cyt deam 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA wobble adenosine to inosine editing|
|tRNA-specific adenosine-34 deaminase complex|
|tRNA-specific adenosine-34 deaminase activity|
|adenosine to inosine editing|
|base conversion or substitution editing|
|tRNA wobble base modification|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|zinc ion binding|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.37|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.83|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.78|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.75|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lars2|LARS2]]|0.461|
|[[:human genes:p:pmvk|PMVK]]|0.432|
|[[:human genes:n:nars2|NARS2]]|0.429|
|[[:human genes:p:pgm3|PGM3]]|0.421|
|[[:human genes:p:pus3|PUS3]]|0.415|
|[[:human genes:s:selrc1|SELRC1]]|0.407|
|[[:human genes:m:mettl1|METTL1]]|0.407|
|[[:human genes:i:iba57|IBA57]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 94/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|1/28|
|bone|4/26|
|breast|3/33|
|central nervous system|11/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|4/20|
|lung|9/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|9/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3073
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAT2 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>