======= ADD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADD1
  * **<color #00a2e8>Official Name</color>**: adducin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=118|118]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35611|P35611]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldolase II|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endothelial cell development|
|positive regulation of establishment of endothelial barrier|
|F-actin capping protein complex|
|hemoglobin metabolic process|
|regulation of endothelial cell development|
|regulation of establishment of endothelial barrier|
|barbed-end actin filament capping|
|positive regulation of endothelial cell differentiation|
|cell volume homeostasis|
|spectrin binding|
|homeostasis of number of cells within a tissue|
|plasma membrane raft|
|positive regulation of adherens junction organization|
|actin filament capping|
|regulation of endothelial cell differentiation|
|negative regulation of actin filament depolymerization|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|IRE1-mediated unfolded protein response|
|positive regulation of epithelial cell differentiation|
|negative regulation of protein depolymerization|
|actin filament bundle assembly|
|actin filament bundle organization|
|negative regulation of protein polymerization|
|regulation of adherens junction organization|
|negative regulation of protein complex disassembly|
|erythrocyte differentiation|
|multicellular organism growth|
|cellular response to calcium ion|
|regulation of protein depolymerization|
|erythrocyte homeostasis|
|positive regulation of protein binding|
|structural constituent of cytoskeleton|
|endoplasmic reticulum unfolded protein response|
|cell-cell adherens junction|
|myeloid cell homeostasis|
|regulation of protein complex disassembly|
|cellular response to unfolded protein|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|regulation of epithelial cell differentiation|
|cellular response to topologically incorrect protein|
|response to calcium ion|
|response to unfolded protein|
|regulation of actin filament polymerization|
|positive regulation of binding|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|response to topologically incorrect protein|
|tissue homeostasis|
|cellular response to metal ion|
|structural molecule activity|
|homeostasis of number of cells|
|calmodulin binding|
|actin filament binding|
|regulation of protein binding|
|cellular response to inorganic substance|
|myeloid cell differentiation|
|regulation of protein polymerization|
|actin filament organization|
|postsynaptic density|
|response to endoplasmic reticulum stress|
|regulation of actin filament organization|
|actin binding|
|nuclear body|
|cadherin binding|
|multicellular organismal homeostasis|
|transcription factor binding|
|anatomical structure homeostasis|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|response to metal ion|
|negative regulation of organelle organization|
|regulation of binding|
|in utero embryonic development|
|regulation of cellular component size|
|developmental growth|
|regulation of actin filament-based process|
|growth|
|focal adhesion|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|protein heterodimerization activity|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|response to inorganic substance|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|hemopoiesis|
|actin filament-based process|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|negative regulation of cellular component organization|
|cell morphogenesis|
|cellular component morphogenesis|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|embryo development|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|transmembrane transport|
|regulation of organelle organization|
|positive regulation of developmental process|
|RNA binding|
|homeostatic process|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.91|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7587
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADD1 Expression in NALM6 Cells: 7.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>