======= ADGRB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGRB1
  * **<color #00a2e8>Official Name</color>**: adhesion G protein-coupled receptor B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=575|575]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14514|O14514]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADGRB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADGRB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602682|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}. Vasculostatin-40: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GPS|
|DUF3497|
|7tm 2|
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|engulfment of apoptotic cell|
|positive regulation of myoblast fusion|
|regulation of myoblast fusion|
|phagocytic cup|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|positive regulation of myotube differentiation|
|lipopolysaccharide binding|
|apoptotic cell clearance|
|negative regulation of endothelial cell migration|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|phosphatidylserine binding|
|positive regulation of synapse assembly|
|negative regulation of epithelial cell migration|
|peripheral nervous system development|
|negative regulation of protein ubiquitination|
|negative regulation of protein modification by small protein conjugation or removal|
|defense response to Gram-negative bacterium|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of muscle cell differentiation|
|PDZ domain binding|
|positive regulation of reactive oxygen species metabolic process|
|regulation of striated muscle cell differentiation|
|negative regulation of angiogenesis|
|regulation of synapse assembly|
|negative regulation of blood vessel morphogenesis|
|phagocytosis, recognition|
|negative regulation of vasculature development|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|phagocytosis, engulfment|
|negative regulation of protein catabolic process|
|plasma membrane invagination|
|membrane invagination|
|cAMP-mediated signaling|
|dendritic spine|
|regulation of muscle cell differentiation|
|regulation of endothelial cell migration|
|cell-cell junction|
|cyclic-nucleotide-mediated signaling|
|regulation of reactive oxygen species metabolic process|
|regulation of synaptic plasticity|
|regulation of protein ubiquitination|
|postsynaptic membrane|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of synapse organization|
|regulation of epithelial cell migration|
|regulation of synapse structure or activity|
|regulation of protein modification by small protein conjugation or removal|
|cell recognition|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|postsynaptic density|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of angiogenesis|
|muscle organ development|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|regulation of vasculature development|
|negative regulation of locomotion|
|phagocytosis|
|defense response to bacterium|
|second-messenger-mediated signaling|
|axonogenesis|
|regulation of protein catabolic process|
|axon development|
|focal adhesion|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|muscle structure development|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|endocytosis|
|cell morphogenesis involved in differentiation|
|negative regulation of protein modification process|
|neuron projection development|
|negative regulation of cell population proliferation|
|import into cell|
|response to bacterium|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|G protein-coupled receptor activity|
|innate immune response|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|membrane organization|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.71|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADGRB1 Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>