======= ADIPOQ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADIPOQ
  * **<color #00a2e8>Official Name</color>**: adiponectin, C1Q and collagen domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9370|9370]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15848|Q15848]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADIPOQ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADIPOQ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605441|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269|PubMed:11479627}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1q|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of oxidative stress|
|positive regulation of metanephric glomerular visceral epithelial cell development|
|negative regulation of metanephric mesenchymal cell migration|
|regulation of metanephric glomerular visceral epithelial cell development|
|positive regulation of renal albumin absorption|
|negative regulation of platelet-derived growth factor receptor-alpha signaling pathway|
|regulation of renal albumin absorption|
|response to linoleic acid|
|negative regulation of low-density lipoprotein particle receptor biosynthetic process|
|regulation of metanephric mesenchymal cell migration|
|positive regulation of glycogen (starch) synthase activity|
|positive regulation of metanephric glomerulus development|
|positive regulation of cAMP-dependent protein kinase activity|
|regulation of platelet-derived growth factor receptor-alpha signaling pathway|
|response to disaccharide|
|negative regulation of vascular associated smooth muscle cell migration|
|regulation of metanephric glomerulus development|
|response to sucrose|
|negative regulation of receptor biosynthetic process|
|negative regulation of macrophage differentiation|
|regulation of glycogen (starch) synthase activity|
|positive regulation of myeloid cell apoptotic process|
|negative regulation of granulocyte differentiation|
|positive regulation of epithelial cell differentiation involved in kidney development|
|negative regulation of metanephros development|
|regulation of low-density lipoprotein particle receptor biosynthetic process|
|negative regulation of heterotypic cell-cell adhesion|
|regulation of cell-cell adhesion involved in gastrulation|
|positive regulation of monocyte chemotactic protein-1 production|
|positive regulation of protein kinase A signaling|
|positive regulation of glomerulus development|
|sialic acid binding|
|negative regulation of receptor binding|
|cellular response to epinephrine stimulus|
|negative regulation of macrophage derived foam cell differentiation|
|protein heterotrimerization|
|negative regulation of protein autophosphorylation|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|positive regulation of metanephros development|
|regulation of glomerulus development|
|regulation of granulocyte differentiation|
|response to epinephrine|
|regulation of monocyte chemotactic protein-1 production|
|positive regulation of cholesterol efflux|
|regulation of cAMP-dependent protein kinase activity|
|negative regulation of kidney development|
|negative regulation of gluconeogenesis|
|negative regulation of vascular smooth muscle cell proliferation|
|regulation of epithelial cell differentiation involved in kidney development|
|regulation of protein kinase A signaling|
|negative regulation of phagocytosis|
|regulation of macrophage differentiation|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of vascular associated smooth muscle cell migration|
|negative regulation of smooth muscle cell migration|
|regulation of receptor biosynthetic process|
|positive regulation of sterol transport|
|regulation of cholesterol efflux|
|positive regulation of cholesterol transport|
|regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of metanephros development|
|regulation of receptor binding|
|low-density lipoprotein particle clearance|
|regulation of heterotypic cell-cell adhesion|
|brown fat cell differentiation|
|regulation of myeloid cell apoptotic process|
|regulation of macrophage derived foam cell differentiation|
|positive regulation of fatty acid metabolic process|
|regulation of renal system process|
|regulation of gastrulation|
|positive regulation of glucose import|
|negative regulation of DNA biosynthetic process|
|plasma lipoprotein particle clearance|
|positive regulation of kidney development|
|negative regulation of intracellular protein transport|
|negative regulation of cellular carbohydrate metabolic process|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of glucose transmembrane transport|
|negative regulation of smooth muscle cell proliferation|
|regulation of gluconeogenesis|
|regulation of cholesterol transport|
|negative regulation of blood pressure|
|regulation of fatty acid biosynthetic process|
|negative regulation of myeloid leukocyte differentiation|
|regulation of sterol transport|
|negative regulation of fat cell differentiation|
|regulation of protein autophosphorylation|
|negative regulation of cold-induced thermogenesis|
|negative regulation of carbohydrate metabolic process|
|positive regulation of interleukin-8 production|
|regulation of vascular smooth muscle cell proliferation|
|cellular response to cAMP|
|protein trimerization|
|regulation of glucose import|
|regulation of kidney development|
|positive regulation of chemokine production|
|fatty acid beta-oxidation|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of tumor necrosis factor production|
|positive regulation of epithelial cell differentiation|
|regulation of smooth muscle cell migration|
|negative regulation of intracellular transport|
|collagen trimer|
|negative regulation of cytokine-mediated signaling pathway|
|positive regulation of lipid transport|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of synaptic transmission|
|negative regulation of hormone secretion|
|negative regulation of response to cytokine stimulus|
|response to activity|
|negative regulation of ERK1 and ERK2 cascade|
|regulation of interleukin-8 production|
|regulation of plasma lipoprotein particle levels|
|regulation of glucose transmembrane transport|
|negative regulation of MAP kinase activity|
|negative regulation of myeloid cell differentiation|
|fatty acid oxidation|
|lipid oxidation|
|regulation of chemokine production|
|positive regulation of lipid localization|
|metanephros development|
|response to fatty acid|
|regulation of fatty acid metabolic process|
|negative regulation of small molecule metabolic process|
|fatty acid catabolic process|
|regulation of carbohydrate biosynthetic process|
|regulation of phagocytosis|
|hormone activity|
|positive regulation of cold-induced thermogenesis|
|response to cAMP|
|negative regulation of leukocyte differentiation|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|negative regulation of protein binding|
|response to catecholamine|
|fat cell differentiation|
|response to monoamine|
|protein heterooligomerization|
|regulation of lipid transport|
|negative regulation of cellular protein localization|
|regulation of DNA biosynthetic process|
|regulation of glucose metabolic process|
|glucose metabolic process|
|regulation of myeloid leukocyte differentiation|
|monocarboxylic acid catabolic process|
|negative regulation of DNA metabolic process|
|regulation of fat cell differentiation|
|response to ethanol|
|regulation of embryonic development|
|regulation of smooth muscle cell proliferation|
|negative regulation of protein serine/threonine kinase activity|
|extracellular matrix structural constituent|
|response to organophosphorus|
|negative regulation of hemopoiesis|
|negative regulation of inflammatory response|
|positive regulation of small molecule metabolic process|
|regulation of lipid localization|
|response to glucose|
|regulation of cellular carbohydrate metabolic process|
|regulation of epithelial cell differentiation|
|positive regulation of lipid metabolic process|
|circadian rhythm|
|response to hexose|
|regulation of cold-induced thermogenesis|
|response to glucocorticoid|
|response to monosaccharide|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|response to purine-containing compound|
|hexose metabolic process|
|response to corticosteroid|
|cellular response to insulin stimulus|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of MAPK cascade|
|negative regulation of binding|
|regulation of cellular ketone metabolic process|
|response to carbohydrate|
|cytokine activity|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|regulation of blood pressure|
|negative regulation of protein transport|
|protein localization to plasma membrane|
|glucose homeostasis|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|carbohydrate homeostasis|
|negative regulation of establishment of protein localization|
|regulation of lipid biosynthetic process|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular lipid catabolic process|
|monosaccharide metabolic process|
|lipid modification|
|positive regulation of transmembrane transport|
|negative regulation of secretion by cell|
|regulation of carbohydrate metabolic process|
|negative regulation of defense response|
|response to nutrient|
|regulation of protein binding|
|negative regulation of protein kinase activity|
|regulation of myeloid cell differentiation|
|response to insulin|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|negative regulation of secretion|
|response to alcohol|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell migration|
|response to tumor necrosis factor|
|cellular response to peptide hormone stimulus|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|kidney development|
|regulation of hormone secretion|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|rhythmic process|
|negative regulation of transferase activity|
|renal system development|
|regulation of ERK1 and ERK2 cascade|
|lipid catabolic process|
|response to antibiotic|
|negative regulation of cellular component movement|
|urogenital system development|
|negative regulation of locomotion|
|fatty acid metabolic process|
|cellular response to peptide|
|response to steroid hormone|
|signaling receptor binding|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|protein homooligomerization|
|regulation of MAP kinase activity|
|response to hypoxia|
|response to acid chemical|
|regulation of intracellular transport|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|regulation of binding|
|response to oxygen levels|
|response to oxidative stress|
|blood circulation|
|response to peptide hormone|
|regulation of lipid metabolic process|
|circulatory system process|
|regulation of cell-cell adhesion|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|response to peptide|
|carbohydrate metabolic process|
|protein localization to membrane|
|negative regulation of transport|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|protein homodimerization activity|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16595
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADIPOQ Expression in NALM6 Cells: 2.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>