======= ADIPOR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADIPOR1
  * **<color #00a2e8>Official Name</color>**: adiponectin receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51094|51094]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A54|Q96A54]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADIPOR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADIPOR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HlyIII|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adipokinetic hormone receptor activity|
|adiponectin binding|
|adiponectin-activated signaling pathway|
|leptin-mediated signaling pathway|
|cellular response to leptin stimulus|
|negative regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of receptor signaling pathway via STAT|
|positive regulation of insulin receptor signaling pathway|
|negative regulation of NIK/NF-kappaB signaling|
|response to leptin|
|positive regulation of cellular response to insulin stimulus|
|negative regulation of epithelial to mesenchymal transition|
|intrinsic component of plasma membrane|
|regulation of fatty acid biosynthetic process|
|regulation of insulin receptor signaling pathway|
|negative regulation of epithelial cell migration|
|regulation of cellular response to insulin stimulus|
|fatty acid oxidation|
|lipid oxidation|
|regulation of epithelial to mesenchymal transition|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of fatty acid metabolic process|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of cold-induced thermogenesis|
|regulation of NIK/NF-kappaB signaling|
|regulation of glucose metabolic process|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|regulation of cellular carbohydrate metabolic process|
|regulation of cold-induced thermogenesis|
|hormone-mediated signaling pathway|
|regulation of cellular ketone metabolic process|
|negative regulation of cell growth|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|lipid modification|
|signaling receptor activity|
|regulation of carbohydrate metabolic process|
|regulation of epithelial cell migration|
|negative regulation of growth|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|fatty acid metabolic process|
|regulation of lipid metabolic process|
|regulation of cell growth|
|regulation of small molecule metabolic process|
|protein kinase binding|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|monocarboxylic acid metabolic process|
|cellular response to hormone stimulus|
|regulation of growth|
|cytokine-mediated signaling pathway|
|negative regulation of cell differentiation|
|regulation of cell migration|
|carboxylic acid metabolic process|
|response to hormone|
|regulation of cell motility|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|regulation of locomotion|
|regulation of cellular component movement|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|identical protein binding|
|response to cytokine|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.05|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.97|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.88|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.72|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.73|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.73|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.76|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.77|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.83|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.83|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.85|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.96|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.97|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.02|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.02|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.03|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.04|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.04|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.09|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.11|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.16|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.2|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.22|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.27|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.3|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.33|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.34|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.38|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.41|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.42|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.72|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.74|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.82|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.97|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10621
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADIPOR1 Expression in NALM6 Cells: 6.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>