======= ADK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADK
  * **<color #00a2e8>Official Name</color>**: adenosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=132|132]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55263|P55263]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102750|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PfkB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenosine kinase activity|
|dATP biosynthetic process|
|AMP salvage|
|purine deoxyribonucleoside triphosphate biosynthetic process|
|purine deoxyribonucleotide biosynthetic process|
|dATP metabolic process|
|purine ribonucleoside salvage|
|AMP biosynthetic process|
|deoxyribonucleoside triphosphate biosynthetic process|
|purine nucleotide salvage|
|purine deoxyribonucleoside triphosphate metabolic process|
|purine deoxyribonucleotide metabolic process|
|deoxyribose phosphate biosynthetic process|
|2-deoxyribonucleotide biosynthetic process|
|AMP metabolic process|
|nucleotide salvage|
|deoxyribonucleotide biosynthetic process|
|purine-containing compound salvage|
|nucleoside salvage|
|deoxyribonucleoside triphosphate metabolic process|
|purine nucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate biosynthetic process|
|purine nucleoside biosynthetic process|
|purine ribonucleoside biosynthetic process|
|ribonucleoside biosynthetic process|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|deoxyribonucleotide metabolic process|
|cellular metabolic compound salvage|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside biosynthetic process|
|glycosyl compound biosynthetic process|
|nucleoside monophosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|purine ribonucleoside metabolic process|
|nucleoside triphosphate biosynthetic process|
|purine nucleoside metabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|nucleoside triphosphate metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-6.2|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-4.02|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-3.58|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-3.42|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.95|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.69|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.61|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.48|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.37|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.36|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.23|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.16|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.05|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.02|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.02|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.01|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.99|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.93|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.92|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.9|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.88|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.85|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.78|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.78|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.75|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.72|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.71|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.71|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.7|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.71|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.73|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.78|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.82|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.86|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.09|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|4.77|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|5.07|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|8.18|
|[[:results:exp116|AICAR 240μM R03 exp116]]|8.5|
|[[:results:exp211|AICAR 240μM R05 exp211]]|8.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nudt2|NUDT2]]|0.636|
|[[:human genes:a:adss|ADSS]]|0.452|
|[[:human genes:m:mtr|MTR]]|0.437|
|[[:human genes:a:ak2|AK2]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18790
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADK Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>