======= ADNP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADNP
  * **<color #00a2e8>Official Name</color>**: activity dependent neuroprotector homeobox
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23394|23394]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2P0|Q9H2P0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADNP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADNP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611386|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nitric oxide homeostasis|
|short-term memory|
|regulation of protein ADP-ribosylation|
|gas homeostasis|
|estrous cycle|
|cGMP-mediated signaling|
|beta-tubulin binding|
|positive regulation of axon extension|
|peptide binding|
|copper ion binding|
|negative regulation of synaptic transmission|
|positive regulation of synapse assembly|
|ovulation cycle|
|positive regulation of axonogenesis|
|regulation of axon extension|
|negative regulation of protein binding|
|regulation of synapse assembly|
|regulation of extent of cell growth|
|memory|
|negative regulation of neuron apoptotic process|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|negative regulation of binding|
|positive regulation of developmental growth|
|response to carbohydrate|
|cyclic-nucleotide-mediated signaling|
|regulation of cell size|
|regulation of axonogenesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of synapse organization|
|regulation of protein binding|
|regulation of synapse structure or activity|
|regulation of peptidyl-tyrosine phosphorylation|
|learning or memory|
|positive regulation of growth|
|cellular response to extracellular stimulus|
|rhythmic process|
|positive regulation of neuron projection development|
|axon|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|activation of protein kinase activity|
|regulation of developmental growth|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|positive regulation of neuron differentiation|
|neuronal cell body|
|regulation of cellular component size|
|regulation of binding|
|positive regulation of cell projection organization|
|chromatin binding|
|regulation of cell growth|
|dendrite|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|behavior|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|DNA binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.54|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.42|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.23|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.17|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.13|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.08|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-2.05|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.92|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.88|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.88|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.83|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.82|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.82|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.81|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.8|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.76|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.72|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.7|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.72|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.73|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10536
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADNP Expression in NALM6 Cells: 7.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>