======= ADORA2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADORA2B
  * **<color #00a2e8>Official Name</color>**: adenosine A2b receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=136|136]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29275|P29275]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADORA2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADORA2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600446|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of chronic inflammatory response to non-antigenic stimulus|
|positive regulation of chronic inflammatory response to non-antigenic stimulus|
|positive regulation of chronic inflammatory response|
|G protein-coupled adenosine receptor activity|
|relaxation of vascular smooth muscle|
|positive regulation of cGMP-mediated signaling|
|relaxation of smooth muscle|
|adenosine receptor signaling pathway|
|regulation of chronic inflammatory response|
|positive regulation of guanylate cyclase activity|
|regulation of guanylate cyclase activity|
|negative regulation of smooth muscle contraction|
|regulation of cGMP-mediated signaling|
|positive regulation of mast cell degranulation|
|positive regulation of mast cell activation involved in immune response|
|G protein-coupled purinergic receptor signaling pathway|
|positive regulation of mast cell activation|
|relaxation of muscle|
|positive regulation of cyclase activity|
|positive regulation of purine nucleotide biosynthetic process|
|positive regulation of nucleotide biosynthetic process|
|negative regulation of muscle contraction|
|positive regulation of lyase activity|
|positive regulation of leukocyte degranulation|
|positive regulation of vascular endothelial growth factor production|
|purinergic receptor signaling pathway|
|vasodilation|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of vascular endothelial growth factor production|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|activation of adenylate cyclase activity|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|excretion|
|regulation of cyclase activity|
|positive regulation of purine nucleotide metabolic process|
|regulation of lyase activity|
|regulation of mast cell activation|
|positive regulation of nucleotide metabolic process|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|cellular defense response|
|positive regulation of chemokine production|
|positive regulation of blood vessel diameter|
|regulation of myeloid leukocyte mediated immunity|
|regulation of smooth muscle contraction|
|regulation of chemokine production|
|regulation of synaptic vesicle exocytosis|
|JNK cascade|
|Schaffer collateral - CA1 synapse|
|positive regulation of exocytosis|
|positive regulation of interleukin-6 production|
|stress-activated MAPK cascade|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of leukocyte mediated immunity|
|positive regulation of small molecule metabolic process|
|positive regulation of inflammatory response|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|regulation of interleukin-6 production|
|stress-activated protein kinase signaling cascade|
|regulation of neurotransmitter transport|
|cAMP-mediated signaling|
|activation of MAPK activity|
|regulation of muscle contraction|
|regulation of regulated secretory pathway|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of immune effector process|
|regulation of exocytosis|
|regulation of muscle system process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of MAP kinase activity|
|cellular response to extracellular stimulus|
|muscle system process|
|activation of protein kinase activity|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|glutamatergic synapse|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|MAPK cascade|
|blood circulation|
|signal transduction by protein phosphorylation|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of cytokine production|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of kinase activity|
|regulation of system process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of cell activation|
|positive regulation of transferase activity|
|regulation of cytokine production|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of protein kinase activity|
|regulation of secretion|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cellular localization|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.73|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.9|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19015
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADORA2B Expression in NALM6 Cells: 1.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>