======= ADRA1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRA1A
  * **<color #00a2e8>Official Name</color>**: adrenoceptor alpha 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=148|148]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35348|P35348]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRA1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRA1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104221|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure|
|regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback|
|baroreceptor response to increased systemic arterial blood pressure|
|positive regulation of the force of heart contraction by epinephrine-norepinephrine|
|alpha1-adrenergic receptor activity|
|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|
|positive regulation of the force of heart contraction by chemical signal|
|regulation of systemic arterial blood pressure by baroreceptor feedback|
|pilomotor reflex|
|positive regulation of heart rate by epinephrine-norepinephrine|
|neuron-glial cell signaling|
|positive regulation of blood pressure by epinephrine-norepinephrine|
|regulation of the force of heart contraction by chemical signal|
|positive regulation of non-membrane spanning protein tyrosine kinase activity|
|micturition|
|regulation of non-membrane spanning protein tyrosine kinase activity|
|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|
|cell growth involved in cardiac muscle cell development|
|physiological cardiac muscle hypertrophy|
|physiological muscle hypertrophy|
|positive regulation of action potential|
|positive regulation of protein kinase C signaling|
|negative regulation of heart rate|
|nervous system process involved in regulation of systemic arterial blood pressure|
|positive regulation of cardiac muscle contraction|
|positive regulation of synaptic transmission, GABAergic|
|dopaminergic synapse|
|positive regulation of systemic arterial blood pressure|
|positive regulation of striated muscle contraction|
|adult heart development|
|regulation of protein kinase C signaling|
|adrenergic receptor activity|
|negative regulation of systemic arterial blood pressure|
|reflex|
|negative regulation of Rho protein signal transduction|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|adrenergic receptor signaling pathway|
|negative regulation of heart contraction|
|positive regulation of heart rate|
|cardiac muscle tissue growth|
|regulation of the force of heart contraction|
|heart growth|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|positive regulation of cardiac muscle hypertrophy|
|vasoconstriction|
|positive regulation of vasoconstriction|
|positive regulation of smooth muscle contraction|
|positive regulation of muscle hypertrophy|
|activation of phospholipase C activity|
|regulation of synaptic transmission, GABAergic|
|muscle hypertrophy|
|negative regulation of blood circulation|
|positive regulation of blood pressure|
|positive regulation of heart contraction|
|negative regulation of blood vessel diameter|
|excretion|
|positive regulation of phospholipase C activity|
|T-tubule|
|negative regulation of blood pressure|
|integral component of postsynaptic membrane|
|positive regulation of muscle contraction|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|regulation of phospholipase C activity|
|regulation of action potential|
|smooth muscle contraction|
|negative regulation of Ras protein signal transduction|
|positive regulation of protein tyrosine kinase activity|
|regulation of cardiac muscle hypertrophy|
|regulation of vasoconstriction|
|integral component of presynaptic membrane|
|negative regulation of small GTPase mediated signal transduction|
|positive regulation of phospholipase activity|
|regulation of muscle hypertrophy|
|regulation of smooth muscle contraction|
|cardiac muscle cell development|
|cardiac cell development|
|GABA-ergic synapse|
|positive regulation of blood circulation|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|calcium ion transport into cytosol|
|caveola|
|regulation of cardiac muscle contraction|
|regulation of synaptic vesicle exocytosis|
|negative regulation of autophagy|
|regulation of muscle adaptation|
|developmental cell growth|
|cardiac muscle cell differentiation|
|cytosolic calcium ion transport|
|regulation of protein tyrosine kinase activity|
|cell growth|
|regulation of striated muscle contraction|
|regulation of systemic arterial blood pressure|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|organ growth|
|regulation of heart rate|
|regulation of lipase activity|
|regulation of neurotransmitter secretion|
|renal system process|
|regulation of synaptic vesicle cycle|
|cardiocyte differentiation|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|Z disc|
|striated muscle cell development|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of neurotransmitter transport|
|regulation of Rho protein signal transduction|
|cAMP-mediated signaling|
|muscle cell development|
|positive regulation of synaptic transmission|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|regulation of regulated secretory pathway|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|positive regulation of peptidyl-tyrosine phosphorylation|
|striated muscle cell differentiation|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of exocytosis|
|regulation of muscle system process|
|nuclear membrane|
|regulation of heart contraction|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|calcium ion transport|
|muscle contraction|
|negative regulation of cellular catabolic process|
|regulation of peptidyl-tyrosine phosphorylation|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|striated muscle tissue development|
|regulation of blood circulation|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|muscle tissue development|
|muscle system process|
|divalent inorganic cation transport|
|negative regulation of catabolic process|
|regulation of cytosolic calcium ion concentration|
|regulation of autophagy|
|second-messenger-mediated signaling|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|developmental growth|
|blood circulation|
|growth|
|circulatory system process|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|heart development|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|cation transport|
|regulation of cellular catabolic process|
|circulatory system development|
|regulation of kinase activity|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|apoptotic process|
|regulation of transferase activity|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5000
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRA1A Expression in NALM6 Cells: 2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>