======= ADRA1D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRA1D
  * **<color #00a2e8>Official Name</color>**: adrenoceptor alpha 1D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=146|146]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25100|P25100]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRA1D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRA1D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104219|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha1-adrenergic receptor activity|
|neuron-glial cell signaling|
|adrenergic receptor activity|
|adrenergic receptor signaling pathway|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|second-messenger-mediated signaling|
|positive regulation of cell population proliferation|
|cell-cell signaling|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of cell population proliferation|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.483|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.482|
|[[:human genes:t:tceb3c|TCEB3C]]|0.474|
|[[:human genes:c:cdc6|CDC6]]|0.453|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.441|
|[[:human genes:p:phf2|PHF2]]|0.428|
|[[:human genes:w:wdr87|WDR87]]|0.425|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.425|
|[[:human genes:e:eif4a3|EIF4A3]]|0.42|
|[[:human genes:c:cope|COPE]]|0.418|
|[[:human genes:s:snrpa1|SNRPA1]]|0.414|
|[[:human genes:a:akirin2|AKIRIN2]]|0.414|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.413|
|[[:human genes:c:c14orf93|C14orf93]]|0.412|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.412|
|[[:human genes:l:lrr1|LRR1]]|0.411|
|[[:human genes:v:vasn|VASN]]|0.41|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.405|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.404|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.404|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.404|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.404|
|[[:human genes:s:slc4a1|SLC4A1]]|0.401|
|[[:human genes:d:dtl|DTL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2741
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRA1D Expression in NALM6 Cells: -4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>