======= ADRA2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRA2A
  * **<color #00a2e8>Official Name</color>**: adrenoceptor alpha 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=150|150]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08913|P08913]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRA2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRA2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase-inhibiting adrenergic receptor signaling pathway|
|phospholipase C-activating adrenergic receptor signaling pathway|
|alpha-2C adrenergic receptor binding|
|alpha-1B adrenergic receptor binding|
|alpha2-adrenergic receptor activity|
|heterotrimeric G-protein binding|
|receptor transactivation|
|norepinephrine binding|
|negative regulation of epinephrine secretion|
|epinephrine binding|
|negative regulation of norepinephrine secretion|
|regulation of epinephrine secretion|
|negative regulation of insulin secretion involved in cellular response to glucose stimulus|
|negative regulation of calcium ion-dependent exocytosis|
|positive regulation of epidermal growth factor-activated receptor activity|
|thioesterase binding|
|negative regulation of catecholamine secretion|
|positive regulation of membrane protein ectodomain proteolysis|
|regulation of norepinephrine secretion|
|adrenergic receptor activity|
|negative regulation of lipid catabolic process|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|adrenergic receptor signaling pathway|
|regulation of membrane protein ectodomain proteolysis|
|negative regulation of amine transport|
|negative regulation of regulated secretory pathway|
|regulation of epidermal growth factor-activated receptor activity|
|positive regulation of epidermal growth factor receptor signaling pathway|
|intestinal absorption|
|activation of protein kinase B activity|
|positive regulation of ERBB signaling pathway|
|positive regulation of signaling receptor activity|
|negative regulation of exocytosis|
|negative regulation of calcium ion transmembrane transporter activity|
|negative regulation of insulin secretion|
|negative regulation of calcium ion transmembrane transport|
|regulation of calcium ion-dependent exocytosis|
|negative regulation of peptide hormone secretion|
|positive regulation of potassium ion transport|
|regulation of lipid catabolic process|
|positive regulation of wound healing|
|positive regulation of protein tyrosine kinase activity|
|regulation of vasoconstriction|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of smooth muscle contraction|
|negative regulation of calcium ion transport|
|regulation of catecholamine secretion|
|negative regulation of hormone secretion|
|positive regulation of response to wounding|
|negative regulation of ion transmembrane transporter activity|
|digestive system process|
|Rho protein signal transduction|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|negative regulation of lipid metabolic process|
|regulation of epidermal growth factor receptor signaling pathway|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of calcium ion transmembrane transporter activity|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|regulation of amine transport|
|regulation of potassium ion transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|negative regulation of ion transmembrane transport|
|digestion|
|negative regulation of transmembrane transport|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|negative regulation of protein secretion|
|platelet activation|
|regulation of wound healing|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|negative regulation of peptide secretion|
|regulation of tube size|
|negative regulation of ion transport|
|cAMP-mediated signaling|
|regulation of calcium ion transmembrane transport|
|regulation of muscle contraction|
|regulation of regulated secretory pathway|
|regulation of response to wounding|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|regulation of signaling receptor activity|
|regulation of insulin secretion|
|negative regulation of protein transport|
|glucose homeostasis|
|carbohydrate homeostasis|
|negative regulation of establishment of protein localization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|basolateral plasma membrane|
|negative regulation of secretion by cell|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|positive regulation of protein catabolic process|
|regulation of exocytosis|
|negative regulation of secretion|
|regulation of muscle system process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|Ras protein signal transduction|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of ion transmembrane transporter activity|
|positive regulation of MAP kinase activity|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|blood coagulation|
|coagulation|
|hemostasis|
|negative regulation of catabolic process|
|small GTPase mediated signal transduction|
|activation of protein kinase activity|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|regulation of lipid metabolic process|
|positive regulation of catabolic process|
|positive regulation of cytokine production|
|protein kinase binding|
|regulation of protein secretion|
|regulation of ion transmembrane transport|
|wound healing|
|negative regulation of transport|
|protein heterodimerization activity|
|regulation of peptide secretion|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|actin filament-based process|
|response to wounding|
|positive regulation of kinase activity|
|regulation of system process|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|regulation of cytokine production|
|regulation of ion transport|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of kinase activity|
|protein homodimerization activity|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|cell activation|
|cytoskeleton organization|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.489|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15086
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRA2A Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>