======= ADRA2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRA2C
  * **<color #00a2e8>Official Name</color>**: adrenoceptor alpha 2C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=152|152]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18825|P18825]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRA2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRA2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of uterine smooth muscle contraction|
|alpha2-adrenergic receptor activity|
|receptor transactivation|
|alpha-2A adrenergic receptor binding|
|negative regulation of epinephrine secretion|
|negative regulation of norepinephrine secretion|
|regulation of epinephrine secretion|
|epinephrine binding|
|regulation of uterine smooth muscle contraction|
|negative regulation of smooth muscle contraction|
|negative regulation of catecholamine secretion|
|regulation of norepinephrine secretion|
|adrenergic receptor activity|
|adrenergic receptor signaling pathway|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|negative regulation of muscle contraction|
|negative regulation of amine transport|
|positive regulation of vasoconstriction|
|activation of protein kinase B activity|
|positive regulation of signaling receptor activity|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|integral component of postsynaptic density membrane|
|axon terminus|
|regulation of vasoconstriction|
|regulation of smooth muscle contraction|
|regulation of catecholamine secretion|
|positive regulation of blood circulation|
|regulation of amine transport|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of nervous system process|
|platelet activation|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|cAMP-mediated signaling|
|regulation of muscle contraction|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|regulation of signaling receptor activity|
|regulation of insulin secretion|
|female pregnancy|
|negative regulation of secretion by cell|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|negative regulation of secretion|
|regulation of muscle system process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of hormone secretion|
|endosome|
|regulation of blood circulation|
|blood coagulation|
|coagulation|
|hemostasis|
|activation of protein kinase activity|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|positive regulation of neuron differentiation|
|neuronal cell body|
|blood circulation|
|circulatory system process|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|wound healing|
|negative regulation of transport|
|protein heterodimerization activity|
|regulation of peptide secretion|
|regulation of body fluid levels|
|regulation of anatomical structure size|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|response to wounding|
|positive regulation of kinase activity|
|regulation of system process|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|cell activation|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15185
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRA2C Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>