======= ADSL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADSL
  * **<color #00a2e8>Official Name</color>**: adenylosuccinate lyase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=158|158]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30566|P30566]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADSL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADSL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608222|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADSL C|
|Lyase 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|
|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity|
|de novo AMP biosynthetic process|
|AMP biosynthetic process|
|de novo IMP biosynthetic process|
|IMP biosynthetic process|
|IMP metabolic process|
|AMP metabolic process|
|purine nucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate biosynthetic process|
|response to muscle activity|
|ribonucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside monophosphate biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|response to activity|
|nucleoside monophosphate metabolic process|
|aerobic respiration|
|purine ribonucleotide biosynthetic process|
|protein tetramerization|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|cellular respiration|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|response to starvation|
|response to nutrient|
|energy derivation by oxidation of organic compounds|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|response to hypoxia|
|response to decreased oxygen levels|
|purine-containing compound metabolic process|
|response to oxygen levels|
|generation of precursor metabolites and energy|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to nutrient levels|
|drug metabolic process|
|protein complex oligomerization|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.59|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.58|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.57|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.57|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.34|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.29|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-2.25|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.24|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.23|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.16|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.16|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.14|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.12|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.06|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.06|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.02|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.02|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.97|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.96|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.96|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.94|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.94|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.94|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.86|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.85|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.82|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.81|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.78|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.77|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.76|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.74|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.74|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.73|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.7|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.7|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.7|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.71|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.72|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.74|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.74|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.83|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.84|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.88|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.9|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.91|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.96|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.16|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.676|
|[[:human genes:g:gmppb|GMPPB]]|0.658|
|[[:human genes:a:alg1|ALG1]]|0.633|
|[[:human genes:r:rpp21|RPP21]]|0.627|
|[[:human genes:d:dpagt1|DPAGT1]]|0.613|
|[[:human genes:r:rtcb|RTCB]]|0.609|
|[[:human genes:a:atxn10|ATXN10]]|0.606|
|[[:human genes:r:rnmt|RNMT]]|0.589|
|[[:human genes:t:triap1|TRIAP1]]|0.581|
|[[:human genes:p:pmm2|PMM2]]|0.578|
|[[:human genes:s:srp14|SRP14]]|0.574|
|[[:human genes:n:nae1|NAE1]]|0.572|
|[[:human genes:u:uap1|UAP1]]|0.569|
|[[:human genes:m:med4|MED4]]|0.567|
|[[:human genes:m:med16|MED16]]|0.562|
|[[:human genes:r:rptor|RPTOR]]|0.561|
|[[:human genes:a:alg13|ALG13]]|0.554|
|[[:human genes:u:uhrf1|UHRF1]]|0.545|
|[[:human genes:u:utp23|UTP23]]|0.542|
|[[:human genes:g:gfpt1|GFPT1]]|0.542|
|[[:human genes:y:yars|YARS]]|0.541|
|[[:human genes:r:rpe|RPE]]|0.54|
|[[:human genes:u:uxt|UXT]]|0.539|
|[[:human genes:g:gemin8|GEMIN8]]|0.537|
|[[:human genes:t:telo2|TELO2]]|0.534|
|[[:human genes:s:slc25a19|SLC25A19]]|0.529|
|[[:human genes:g:gnb1l|GNB1L]]|0.528|
|[[:human genes:v:vezt|VEZT]]|0.527|
|[[:human genes:h:hspd1|HSPD1]]|0.526|
|[[:human genes:e:eny2|ENY2]]|0.523|
|[[:human genes:e:eprs|EPRS]]|0.523|
|[[:human genes:d:dr1|DR1]]|0.522|
|[[:human genes:f:fen1|FEN1]]|0.521|
|[[:human genes:t:txnl4b|TXNL4B]]|0.521|
|[[:human genes:e:exoc4|EXOC4]]|0.52|
|[[:human genes:t:tsen54|TSEN54]]|0.519|
|[[:human genes:p:ppp4c|PPP4C]]|0.519|
|[[:human genes:z:zrsr2|ZRSR2]]|0.519|
|[[:human genes:a:atp5j|ATP5J]]|0.519|
|[[:human genes:d:dolk|DOLK]]|0.518|
|[[:human genes:t:tti2|TTI2]]|0.518|
|[[:human genes:d:dohh|DOHH]]|0.517|
|[[:human genes:u:urm1|URM1]]|0.517|
|[[:human genes:s:ssb|SSB]]|0.517|
|[[:human genes:d:dhps|DHPS]]|0.512|
|[[:human genes:p:polr3h|POLR3H]]|0.511|
|[[:human genes:e:elac2|ELAC2]]|0.51|
|[[:human genes:d:ddx20|DDX20]]|0.507|
|[[:human genes:r:rad1|RAD1]]|0.506|
|[[:human genes:t:tprkb|TPRKB]]|0.505|
|[[:human genes:a:atp5o|ATP5O]]|0.504|
|[[:human genes:n:naf1|NAF1]]|0.504|
|[[:human genes:t:tti1|TTI1]]|0.503|
|[[:human genes:e:eif3f|EIF3F]]|0.5|
|[[:human genes:g:gemin6|GEMIN6]]|0.5|
|[[:human genes:p:pelo|PELO]]|0.499|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.497|
|[[:human genes:t:trmt5|TRMT5]]|0.496|
|[[:human genes:e:eif4e|EIF4E]]|0.496|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.495|
|[[:human genes:o:osgep|OSGEP]]|0.495|
|[[:human genes:r:rpia|RPIA]]|0.495|
|[[:human genes:a:atp5b|ATP5B]]|0.493|
|[[:human genes:a:atic|ATIC]]|0.492|
|[[:human genes:p:ppp6c|PPP6C]]|0.491|
|[[:human genes:t:tpk1|TPK1]]|0.49|
|[[:human genes:f:fnta|FNTA]]|0.49|
|[[:human genes:t:tgs1|TGS1]]|0.487|
|[[:human genes:c:chchd4|CHCHD4]]|0.487|
|[[:human genes:t:ten1|TEN1]]|0.487|
|[[:human genes:r:rabggtb|RABGGTB]]|0.487|
|[[:human genes:h:haus8|HAUS8]]|0.486|
|[[:human genes:u:uba3|UBA3]]|0.485|
|[[:human genes:p:ppcs|PPCS]]|0.483|
|[[:human genes:t:thoc3|THOC3]]|0.48|
|[[:human genes:c:cep57|CEP57]]|0.477|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.476|
|[[:human genes:f:fh|FH]]|0.475|
|[[:human genes:s:sec61g|SEC61G]]|0.474|
|[[:human genes:a:atp5a1|ATP5A1]]|0.474|
|[[:human genes:t:trnt1|TRNT1]]|0.474|
|[[:human genes:g:gemin7|GEMIN7]]|0.473|
|[[:human genes:s:slc25a26|SLC25A26]]|0.472|
|[[:human genes:t:tbca|TBCA]]|0.468|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.466|
|[[:human genes:c:c15orf41|C15orf41]]|0.465|
|[[:human genes:o:oraov1|ORAOV1]]|0.464|
|[[:human genes:b:bap1|BAP1]]|0.463|
|[[:human genes:e:exoc3|EXOC3]]|0.461|
|[[:human genes:c:cct7|CCT7]]|0.461|
|[[:human genes:c:ccdc101|CCDC101]]|0.46|
|[[:human genes:r:rad50|RAD50]]|0.458|
|[[:human genes:v:vrk1|VRK1]]|0.457|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.454|
|[[:human genes:e:elp3|ELP3]]|0.452|
|[[:human genes:r:rfk|RFK]]|0.452|
|[[:human genes:u:ube2g2|UBE2G2]]|0.451|
|[[:human genes:n:naa20|NAA20]]|0.451|
|[[:human genes:d:ddx55|DDX55]]|0.449|
|[[:human genes:v:vhl|VHL]]|0.449|
|[[:human genes:a:alg14|ALG14]]|0.449|
|[[:human genes:e:ercc2|ERCC2]]|0.448|
|[[:human genes:k:kdm8|KDM8]]|0.447|
|[[:human genes:p:ppa2|PPA2]]|0.447|
|[[:human genes:a:alg2|ALG2]]|0.446|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.446|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.446|
|[[:human genes:e:eno1|ENO1]]|0.445|
|[[:human genes:d:dad1|DAD1]]|0.444|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.444|
|[[:human genes:a:alg6|ALG6]]|0.443|
|[[:human genes:p:paxip1|PAXIP1]]|0.442|
|[[:human genes:t:tamm41|TAMM41]]|0.442|
|[[:human genes:c:casp9|CASP9]]|0.44|
|[[:human genes:m:msto1|MSTO1]]|0.439|
|[[:human genes:e:elp2|ELP2]]|0.438|
|[[:human genes:g:gpn2|GPN2]]|0.438|
|[[:human genes:d:dld|DLD]]|0.437|
|[[:human genes:n:nars|NARS]]|0.437|
|[[:human genes:d:dicer1|DICER1]]|0.437|
|[[:human genes:a:aars|AARS]]|0.435|
|[[:human genes:w:wdr92|WDR92]]|0.435|
|[[:human genes:d:dctn6|DCTN6]]|0.434|
|[[:human genes:h:hccs|HCCS]]|0.433|
|[[:human genes:l:lsm11|LSM11]]|0.433|
|[[:human genes:e:eftud1|EFTUD1]]|0.433|
|[[:human genes:n:nsmce1|NSMCE1]]|0.432|
|[[:human genes:r:rft1|RFT1]]|0.429|
|[[:human genes:p:pdss1|PDSS1]]|0.429|
|[[:human genes:m:mapk14|MAPK14]]|0.429|
|[[:human genes:c:c21orf59|C21orf59]]|0.428|
|[[:human genes:g:gemin5|GEMIN5]]|0.428|
|[[:human genes:a:atm|ATM]]|0.427|
|[[:human genes:m:mllt1|MLLT1]]|0.427|
|[[:human genes:a:alg5|ALG5]]|0.425|
|[[:human genes:k:kctd5|KCTD5]]|0.424|
|[[:human genes:c:crcp|CRCP]]|0.423|
|[[:human genes:o:oip5|OIP5]]|0.423|
|[[:human genes:a:atrx|ATRX]]|0.422|
|[[:human genes:s:sec62|SEC62]]|0.422|
|[[:human genes:l:lsm10|LSM10]]|0.422|
|[[:human genes:c:csnk2b|CSNK2B]]|0.421|
|[[:human genes:b:bub3|BUB3]]|0.42|
|[[:human genes:t:timm13|TIMM13]]|0.42|
|[[:human genes:w:wdr82|WDR82]]|0.42|
|[[:human genes:t:taf1a|TAF1A]]|0.419|
|[[:human genes:m:mtor|MTOR]]|0.418|
|[[:human genes:p:pam16|PAM16]]|0.418|
|[[:human genes:c:cox5a|COX5A]]|0.417|
|[[:human genes:a:atp5f1|ATP5F1]]|0.417|
|[[:human genes:c:c17orf89|C17orf89]]|0.416|
|[[:human genes:z:znhit1|ZNHIT1]]|0.416|
|[[:human genes:r:rbmx2|RBMX2]]|0.416|
|[[:human genes:p:pggt1b|PGGT1B]]|0.416|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.416|
|[[:human genes:t:ttc4|TTC4]]|0.415|
|[[:human genes:t:thoc6|THOC6]]|0.415|
|[[:human genes:w:wdr59|WDR59]]|0.415|
|[[:human genes:t:timm22|TIMM22]]|0.414|
|[[:human genes:t:tmem242|TMEM242]]|0.414|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.413|
|[[:human genes:t:tsen34|TSEN34]]|0.412|
|[[:human genes:s:seh1l|SEH1L]]|0.412|
|[[:human genes:m:mis18a|MIS18A]]|0.41|
|[[:human genes:n:nbn|NBN]]|0.41|
|[[:human genes:s:snapc5|SNAPC5]]|0.41|
|[[:human genes:p:pgm3|PGM3]]|0.41|
|[[:human genes:x:xrcc3|XRCC3]]|0.41|
|[[:human genes:a:atp5h|ATP5H]]|0.41|
|[[:human genes:t:tbcb|TBCB]]|0.409|
|[[:human genes:z:zcrb1|ZCRB1]]|0.408|
|[[:human genes:x:xrcc2|XRCC2]]|0.408|
|[[:human genes:b:bcs1l|BCS1L]]|0.408|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.408|
|[[:human genes:b:bak1|BAK1]]|0.407|
|[[:human genes:c:cbfb|CBFB]]|0.406|
|[[:human genes:t:tmem41b|TMEM41B]]|0.405|
|[[:human genes:c:ciao1|CIAO1]]|0.405|
|[[:human genes:d:dpf2|DPF2]]|0.405|
|[[:human genes:t:tkt|TKT]]|0.404|
|[[:human genes:c:cdipt|CDIPT]]|0.403|
|[[:human genes:w:wdr24|WDR24]]|0.403|
|[[:human genes:r:romo1|ROMO1]]|0.403|
|[[:human genes:t:tbcd|TBCD]]|0.401|
|[[:human genes:m:mrps14|MRPS14]]|0.401|
|[[:human genes:s:sgol1|SGOL1]]|0.401|
|[[:human genes:t:trmt10a|TRMT10A]]|0.401|
|[[:human genes:s:spcs2|SPCS2]]|0.401|
|[[:human genes:u:ube2m|UBE2M]]|0.4|
|[[:human genes:c:c14orf166|C14orf166]]|0.4|
|[[:human genes:k:kif14|KIF14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 407/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|27/28|
|bone|11/26|
|breast|28/33|
|central nervous system|13/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|9/21|
|liver|6/20|
|lung|41/75|
|lymphocyte|12/16|
|ovary|7/26|
|pancreas|19/24|
|peripheral nervous system|4/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|15/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1352
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADSL Expression in NALM6 Cells: 6.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>