======= AFF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AFF1
  * **<color #00a2e8>Official Name</color>**: AF4/FMR2 family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4299|4299]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51825|P51825]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AFF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AFF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159557|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AF-4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ELL-EAF complex|
|transcription elongation factor complex|
|double-stranded DNA binding|
|DNA-binding transcription factor activity|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.73|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.87|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.88|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.88|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.93|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.98|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.02|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.11|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.14|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.24|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.49|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.77|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13l|MED13L]]|0.5|
|[[:human genes:t:taf5l|TAF5L]]|0.459|
|[[:human genes:m:med13|MED13]]|0.451|
|[[:human genes:u:ubald2|UBALD2]]|0.446|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.434|
|[[:human genes:s:setdb1|SETDB1]]|0.428|
|[[:human genes:a:atat1|ATAT1]]|0.422|
|[[:human genes:e:ehmt2|EHMT2]]|0.414|
|[[:human genes:t:tceb3|TCEB3]]|0.414|
|[[:human genes:k:kpna6|KPNA6]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1783
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AFF1 Expression in NALM6 Cells: 7.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>