======= AGO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGO1
  * **<color #00a2e8>Official Name</color>**: argonaute RISC component 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26523|26523]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL18|Q9UL18]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606228|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:18771919}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAZ|
|DUF1785|
|Piwi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA cleavage involved in gene silencing by siRNA|
|mRNA cleavage involved in gene silencing|
|mRNA cleavage involved in gene silencing by miRNA|
|miRNA loading onto RISC involved in gene silencing by miRNA|
|RNA secondary structure unwinding|
|small RNA loading onto RISC|
|RISC-loading complex|
|negative regulation of translation, ncRNA-mediated|
|miRNA mediated inhibition of translation|
|regulation of translation, ncRNA-mediated|
|core promoter binding|
|pre-miRNA processing|
|RISC complex|
|RNA interference|
|miRNA metabolic process|
|mRNA cleavage|
|endoribonuclease activity|
|production of miRNAs involved in gene silencing by miRNA|
|miRNA binding|
|RNA polymerase II complex binding|
|production of small RNA involved in gene silencing by RNA|
|dsRNA processing|
|Wnt signaling pathway, calcium modulating pathway|
|polysome|
|single-stranded RNA binding|
|gene silencing by miRNA|
|regulation of megakaryocyte differentiation|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|double-stranded RNA binding|
|positive regulation of NIK/NF-kappaB signaling|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|P-body|
|regulation of gene silencing by miRNA|
|gene silencing by RNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of vasculature development|
|regulation of gene silencing|
|negative regulation of translation|
|non-canonical Wnt signaling pathway|
|negative regulation of cellular amide metabolic process|
|gene silencing|
|ribonucleoprotein complex|
|RNA phosphodiester bond hydrolysis|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|regulation of myeloid cell differentiation|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|regulation of angiogenesis|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of vasculature development|
|regulation of translation|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of hemopoiesis|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|cellular macromolecule catabolic process|
|negative regulation of developmental process|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15319
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGO1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>