======= AGO3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGO3
  * **<color #00a2e8>Official Name</color>**: argonaute RISC catalytic component 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=192669|192669]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9G7|Q9H9G7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGO3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGO3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607355|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. {ECO:0000255|HAMAP- Rule:MF_03032, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:23064648}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Piwi|
|DUF1785|
|PAZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoribonuclease activity, cleaving miRNA-paired mRNA|
|mRNA cleavage involved in gene silencing by siRNA|
|mRNA cleavage involved in gene silencing by miRNA|
|mRNA cleavage involved in gene silencing|
|miRNA loading onto RISC involved in gene silencing by miRNA|
|RNA secondary structure unwinding|
|RISC-loading complex|
|small RNA loading onto RISC|
|regulation of translation, ncRNA-mediated|
|miRNA mediated inhibition of translation|
|negative regulation of translation, ncRNA-mediated|
|pre-miRNA processing|
|RISC complex|
|RNA interference|
|mRNA cleavage|
|endoribonuclease activity|
|production of miRNAs involved in gene silencing by miRNA|
|condensed nuclear chromosome|
|miRNA binding|
|production of small RNA involved in gene silencing by RNA|
|dsRNA processing|
|Wnt signaling pathway, calcium modulating pathway|
|single-stranded RNA binding|
|gene silencing by miRNA|
|regulation of megakaryocyte differentiation|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|regulation of stem cell proliferation|
|cytoplasmic ribonucleoprotein granule|
|double-stranded RNA binding|
|positive regulation of NIK/NF-kappaB signaling|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|P-body|
|gene silencing by RNA|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of translation|
|non-canonical Wnt signaling pathway|
|negative regulation of cellular amide metabolic process|
|gene silencing|
|RNA phosphodiester bond hydrolysis|
|mRNA catabolic process|
|regulation of myeloid cell differentiation|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of translation|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of hemopoiesis|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|cellular macromolecule catabolic process|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.04|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.01|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.91|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-1.83|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.76|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.74|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.77|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.77|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16371
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGO3 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>