======= AGT =======
== Gene Information ==
* **Official Symbol**: AGT
* **Official Name**: angiotensinogen
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=183|183]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P01019|P01019]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=AGT&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGT|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/106150|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-3: stimulates aldosterone release.
|Serpin|
|type 2 angiotensin receptor binding|
|positive regulation of L-lysine import across plasma membrane|
|regulation of L-lysine import across plasma membrane|
|regulation of L-arginine import across plasma membrane|
|positive regulation of L-arginine import across plasma membrane|
|uterine smooth muscle contraction|
|fibroblast proliferation|
|G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger|
|angiotensin-mediated drinking behavior|
|regulation of L-arginine import|
|brain renin-angiotensin system|
|positive regulation of gap junction assembly|
|operant conditioning|
|positive regulation of extracellular matrix constituent secretion|
|response to muscle activity involved in regulation of muscle adaptation|
|regulation of renal output by angiotensin|
|smooth muscle cell proliferation|
|negative regulation of neurotrophin TRK receptor signaling pathway|
|renin-angiotensin regulation of aldosterone production|
|regulation of gap junction assembly|
|regulation of blood vessel diameter by renin-angiotensin|
|renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure|
|regulation of aldosterone secretion|
|regulation of mineralocorticoid secretion|
|type 1 angiotensin receptor binding|
|regulation of extracellular matrix constituent secretion|
|positive regulation of activation of Janus kinase activity|
|positive regulation of NAD(P)H oxidase activity|
|positive regulation of anion transmembrane transport|
|regulation of blood volume by renin-angiotensin|
|regulation of amino acid transmembrane transport|
|regulation of amino acid import across plasma membrane|
|cell growth involved in cardiac muscle cell development|
|positive regulation of cholesterol esterification|
|regulation of activation of Janus kinase activity|
|physiological muscle hypertrophy|
|regulation of extracellular matrix assembly|
|physiological cardiac muscle hypertrophy|
|drinking behavior|
|artery smooth muscle contraction|
|nervous system process involved in regulation of systemic arterial blood pressure|
|regulation of NAD(P)H oxidase activity|
|regulation of cholesterol esterification|
|tonic smooth muscle contraction|
|low-density lipoprotein particle remodeling|
|regulation of neurotrophin TRK receptor signaling pathway|
|positive regulation of striated muscle cell apoptotic process|
|positive regulation of cardiac muscle cell apoptotic process|
|positive regulation of renal sodium excretion|
|response to stimulus involved in regulation of muscle adaptation|
|regulation of norepinephrine secretion|
|regulation of corticosteroid hormone secretion|
|positive regulation of vascular associated smooth muscle cell migration|
|positive regulation of macrophage derived foam cell differentiation|
|vascular smooth muscle contraction|
|regulation of transmission of nerve impulse|
|cellular sodium ion homeostasis|
|positive regulation of branching involved in ureteric bud morphogenesis|
|muscle cell proliferation|
|positive regulation of amino acid transport|
|positive regulation of superoxide anion generation|
|regulation of steroid hormone secretion|
|nitric oxide mediated signal transduction|
|negative regulation of tissue remodeling|
|positive regulation of mesonephros development|
|cellular response to angiotensin|
|regulation of renal sodium excretion|
|positive regulation of extracellular matrix organization|
|positive regulation of insulin receptor signaling pathway|
|regulation of branching involved in ureteric bud morphogenesis|
|regulation of superoxide anion generation|
|regulation of vascular associated smooth muscle cell migration|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|regulation of excretion|
|renal system process involved in regulation of systemic arterial blood pressure|
|positive regulation of cellular response to insulin stimulus|
|response to muscle activity|
|regulation of mesonephros development|
|response to angiotensin|
|regulation of anion transmembrane transport|
|regulation of long-term neuronal synaptic plasticity|
|cardiac muscle tissue growth|
|positive regulation of steroid metabolic process|
|ERK1 and ERK2 cascade|
|protein-lipid complex remodeling|
|heart growth|
|plasma lipoprotein particle remodeling|
|positive regulation of muscle cell apoptotic process|
|protein-containing complex remodeling|
|regulation of macrophage derived foam cell differentiation|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|positive regulation of cardiac muscle hypertrophy|
|vasodilation|
|positive regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of response to drug|
|regulation of amino acid transport|
|vasoconstriction|
|positive regulation of muscle hypertrophy|
|activation of phospholipase C activity|
|muscle hypertrophy|
|blood vessel remodeling|
|positive regulation of ERBB signaling pathway|
|positive regulation of vascular smooth muscle cell proliferation|
|positive regulation of cell junction assembly|
|regulation of superoxide metabolic process|
|sodium ion homeostasis|
|positive regulation of organic acid transport|
|positive regulation of morphogenesis of an epithelium|
|positive regulation of amine transport|
|regulation of renal system process|
|regulation of cardiac muscle cell apoptotic process|
|positive regulation of smooth muscle cell migration|
|positive regulation of blood pressure|
|regulation of systemic arterial blood pressure by hormone|
|regulation of extracellular matrix organization|
|regulation of striated muscle cell apoptotic process|
|positive regulation of nitric oxide biosynthetic process|
|negative regulation of blood vessel diameter|
|positive regulation of kidney development|
|positive regulation of nitric oxide metabolic process|
|positive regulation of phospholipase C activity|
|plasma lipoprotein particle organization|
|regulation of endocrine process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|regulation of phospholipase C activity|
|protein-lipid complex subunit organization|
|cytokine secretion|
|endocrine process|
|positive regulation of extrinsic apoptotic signaling pathway|
|regulation of vascular smooth muscle cell proliferation|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of fibroblast proliferation|
|positive regulation of anion transport|
|smooth muscle contraction|
|regulation of neuronal synaptic plasticity|
|positive regulation of oxidoreductase activity|
|regulation of kidney development|
|positive regulation of protein tyrosine kinase activity|
|regulation of nitric oxide biosynthetic process|
|regulation of cardiac muscle hypertrophy|
|regulation of morphogenesis of a branching structure|
|positive regulation of blood vessel diameter|
|regulation of vasoconstriction|
|regulation of organic acid transport|
|regulation of muscle hypertrophy|
|positive regulation of phospholipase activity|
|cardiac muscle cell development|
|regulation of smooth muscle cell migration|
|regulation of catecholamine secretion|
|regulation of insulin receptor signaling pathway|
|cardiac cell development|
|response to activity|
|regulation of cardiac conduction|
|regulation of muscle cell apoptotic process|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|regulation of plasma lipoprotein particle levels|
|regulation of cellular response to insulin stimulus|
|regulation of tissue remodeling|
|associative learning|
|cellular response to mechanical stimulus|
|positive regulation of animal organ morphogenesis|
|regulation of fibroblast proliferation|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of reactive oxygen species biosynthetic process|
|feeding behavior|
|positive regulation of smooth muscle cell proliferation|
|regulation of muscle adaptation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|cardiac muscle cell differentiation|
|positive regulation of receptor signaling pathway via STAT|
|developmental cell growth|
|regulation of cell junction assembly|
|regulation of protein tyrosine kinase activity|
|cell growth|
|regulation of ERBB signaling pathway|
|regulation of amine transport|
|regulation of systemic arterial blood pressure|
|protein import into nucleus|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of reactive oxygen species metabolic process|
|regulation of oxidoreductase activity|
|regulation of anion transport|
|serine-type endopeptidase inhibitor activity|
|organ growth|
|regulation of heart rate|
|regulation of lipase activity|
|hormone activity|
|regulation of response to drug|
|positive regulation of endothelial cell migration|
|tissue remodeling|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|stress-activated MAPK cascade|
|regulation of lipid transport|
|cellular monovalent inorganic cation homeostasis|
|renal system process|
|import into nucleus|
|regulation of steroid metabolic process|
|negative regulation of vasculature development|
|cardiocyte differentiation|
|regulation of phosphatidylinositol 3-kinase signaling|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|striated muscle cell development|
|response to estradiol|
|regulation of nervous system process|
|regulation of lipid localization|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|positive regulation of inflammatory response|
|monovalent inorganic cation homeostasis|
|regulation of tube size|
|positive regulation of epithelial cell migration|
|positive regulation of cation transmembrane transport|
|blood microparticle|
|positive regulation of lipid metabolic process|
|stress-activated protein kinase signaling cascade|
|protein import|
|learning|
|negative regulation of cellular response to growth factor stimulus|
|muscle cell development|
|cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of ion transmembrane transport|
|protein secretion|
|regulation of endothelial cell migration|
|establishment of protein localization to extracellular region|
|protein localization to nucleus|
|cardiac muscle tissue development|
|growth factor activity|
|protein localization to extracellular region|
|vascular process in circulatory system|
|peptide secretion|
|positive regulation of apoptotic signaling pathway|
|regulation of reactive oxygen species metabolic process|
|female pregnancy|
|regulation of morphogenesis of an epithelium|
|regulation of blood pressure|
|negative regulation of cell growth|
|regulation of synaptic plasticity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|striated muscle cell differentiation|
|positive regulation of transmembrane transport|
|multi-multicellular organism process|
|response to mechanical stimulus|
|regulation of epithelial cell migration|
|regulation of muscle system process|
|negative regulation of growth|
|regulation of heart contraction|
|negative regulation of endopeptidase activity|
|muscle cell differentiation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of peptidase activity|
|regulation of animal organ morphogenesis|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|nucleocytoplasmic transport|
|cellular response to peptide hormone stimulus|
|nuclear transport|
|regulation of hormone secretion|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|positive regulation of ion transport|
|aging|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|striated muscle tissue development|
|renal system development|
|regulation of angiogenesis|
|regulation of blood circulation|
|muscle tissue development|
|cognition|
|muscle system process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|urogenital system development|
|regulation of vasculature development|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|negative regulation of proteolysis|
|regulation of neurotransmitter levels|
|collagen-containing extracellular matrix|
|positive regulation of neuron differentiation|
|MAPK cascade|
|positive regulation of cell projection organization|
|extracellular structure organization|
|regulation of metal ion transport|
|developmental growth|
|blood circulation|
|response to peptide hormone|
|growth|
|signal transduction by protein phosphorylation|
|circulatory system process|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|regulation of cell growth|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|establishment of protein localization to organelle|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|response to peptide|
|positive regulation of defense response|
|muscle structure development|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|heart development|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|cell population proliferation|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of growth|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|regulation of proteolysis|
|protein localization to organelle|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of defense response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|intracellular protein transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.98|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 6164
* **Expression level (log2 read counts)**: -6.6
{{:chemogenomics:nalm6 dist.png?nolink |}}