======= AGTR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGTR1
  * **<color #00a2e8>Official Name</color>**: angiotensin II receptor type 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=185|185]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30556|P30556]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGTR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGTR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/106165|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|angiotensin type I receptor activity|
|phospholipase C-activating angiotensin-activated signaling pathway|
|bradykinin receptor binding|
|angiotensin type II receptor activity|
|renin-angiotensin regulation of aldosterone production|
|renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure|
|regulation of blood vessel diameter by renin-angiotensin|
|regulation of aldosterone secretion|
|regulation of mineralocorticoid secretion|
|positive regulation of phospholipase A2 activity|
|positive regulation of NAD(P)H oxidase activity|
|regulation of blood volume by renin-angiotensin|
|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|positive regulation of cholesterol esterification|
|angiotensin-activated signaling pathway|
|regulation of cholesterol esterification|
|regulation of NAD(P)H oxidase activity|
|regulation of phospholipase A2 activity|
|low-density lipoprotein particle remodeling|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|positive regulation of macrophage derived foam cell differentiation|
|regulation of corticosteroid hormone secretion|
|regulation of steroid hormone secretion|
|regulation of renal sodium excretion|
|cellular response to angiotensin|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|renal system process involved in regulation of systemic arterial blood pressure|
|regulation of excretion|
|response to angiotensin|
|positive regulation of steroid metabolic process|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|regulation of macrophage derived foam cell differentiation|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|regulation of renal system process|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of sprouting angiogenesis|
|plasma lipoprotein particle organization|
|regulation of endocrine process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|protein-lipid complex subunit organization|
|endocrine process|
|positive regulation of oxidoreductase activity|
|regulation of vasoconstriction|
|positive regulation of phospholipase activity|
|regulation of sprouting angiogenesis|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|regulation of plasma lipoprotein particle levels|
|Rho protein signal transduction|
|regulation of systemic arterial blood pressure|
|positive regulation of endothelial cell proliferation|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of reactive oxygen species metabolic process|
|regulation of oxidoreductase activity|
|regulation of lipase activity|
|regulation of lipid transport|
|renal system process|
|regulation of steroid metabolic process|
|regulation of endothelial cell proliferation|
|regulation of lipid localization|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|positive regulation of inflammatory response|
|regulation of tube size|
|positive regulation of lipid metabolic process|
|calcium-mediated signaling|
|positive regulation of angiogenesis|
|vascular process in circulatory system|
|regulation of reactive oxygen species metabolic process|
|regulation of blood pressure|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|cell chemotaxis|
|Ras protein signal transduction|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|kidney development|
|positive regulation of cytosolic calcium ion concentration|
|renal system development|
|regulation of angiogenesis|
|regulation of blood circulation|
|urogenital system development|
|small GTPase mediated signal transduction|
|regulation of vasculature development|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|regulation of epithelial cell proliferation|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|extracellular structure organization|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|regulation of lipid metabolic process|
|regulation of cell growth|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|positive regulation of defense response|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|inflammatory response|
|regulation of anatomical structure size|
|regulation of hormone levels|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|regulation of system process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|regulation of growth|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of defense response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of secretion|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|cell migration|
|positive regulation of cell differentiation|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11401
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGTR1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>